PPP4R3A and CASK

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PPP4R3A	CASK
Description		protein phosphatase 4 regulatory subunit 3A	calcium/calmodulin dependent serine protein kinase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck Protein Phosphatase 4 Complex	Basement Membrane Nucleus Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Nuclear Matrix Cell Junction Vesicle Presynaptic Membrane Synapse Ciliary Membrane Cell Periphery Schaffer Collateral - CA1 Synapse
	Molecular Function	Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity	Nucleotide Binding GMP Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Neurexin Family Protein Binding Protein Serine Kinase Activity
	Biological Process	Gluconeogenesis DNA Damage Response Positive Regulation Of Gluconeogenesis Regulation Of Double-strand Break Repair	Negative Regulation Of Cell-matrix Adhesion Cell Adhesion Intracellular Protein Localization Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Transcription By RNA Polymerase II GMP Metabolic Process GDP Metabolic Process Regulation Of Neurotransmitter Secretion Establishment Of Localization In Cell Negative Regulation Of Wound Healing Calcium Ion Import Positive Regulation Of Calcium Ion Import Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Synaptic Vesicle Exocytosis
Pathways			Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs			Formic acid Fostamatinib
Diseases			FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS		Decline in glucose metabolism in posterior cingulate cortex ( 29130521)
Interacting Genes		6 interacting genes: CASK CDK1 CEBPA MAPK14 PEA15 RNF113A	90 interacting genes: AKAP9 APBA1 ATP2B4 BNIP3L CADM1 CASKIN1 CDK9 CIMIP1 CNTNAP2 CNTNAP4 DDX54 DLG1 DLG4 DUSP3 ELL2 EPB41 EPS8 ERBIN F11R FCHSD2 FMR1 GCNT3 GLS2 GRIK2 GRIN2A GTSE1 HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 KIF2A KLC4 LIN7A LIN7B MAPRE1 MAPRE2 MARK2 MARS1 MED1 MLLT6 MLX NDEL1 NPHS1 NRXN1 NRXN2 NRXN3 NTN4 P2RX7 PARD3B PARD6G PCBP2 PCM1 PKP2 PLK2 PPP4R3A PRC1 PRKCI PRKD2 PRKN PRPF3 PTGS2 RAB3A RBBP6 RBM10 RBM14 RBM5 RPA2 RPH3A RSPH1 SDC1 SDC2 SDC3 SDC4 SF3B2 SH2D4A SLAIN2 SRPK2 TANC1 TBR1 TIAM1 TRIM22 TSPYL2 UBC WHRN WNT7B YWHAE
Entrez ID		55671	8573
HPRD ID		11176	02164
Ensembl ID		ENSG00000100796	ENSG00000147044
Uniprot IDs		Q6IN85 Q8N6W1	A0A2R8YE77 A0A2U3TZM1 A0A7I2RJN6 O14936
PDB IDs		6R8I	1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC 6KMH 7OAI 7OAJ 7OAK 7OAL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Heart Growth Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Intracellular Signaling Cassette MAPK Cascade Positive Regulation Of Protein Import Into Nucleus Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Organ Growth Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Heart Growth Protein Serine/threonine Kinase Activity Positive Regulation Of Fat Cell Differentiation Energy Homeostasis Regulation Of D-glucose Import Regulation Of D-glucose Transmembrane Transport Pronuclear Fusion RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Nucleobase-containing Compound Metabolic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Organ Growth Protein Kinase Activity Positive Regulation Of Protein Localization To Nucleus DNA Damage Checkpoint Signaling Cellular Response To Tumor Necrosis Factor Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Regulation Of Nucleocytoplasmic Transport Small Molecule Metabolic Process Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Response To Tumor Necrosis Factor Response To Vitamin B2 C/EBP Complex SnoRNA Splicing Cellular Response To Stress Positive Regulation Of Intracellular Transport Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Regulation Of Intracellular Protein Transport Regulation Of Transport Kinase Activity Cyclin-dependent Protein Kinase Activity Regulation Of Fat Cell Differentiation CHOP-C/EBP Complex Nuclear Matrix Myeloid Leukocyte Differentiation Regulation Of Synaptic Membrane Adhesion Regulation Of Cell Population Proliferation	Neuroligin Family Protein Binding Glutamatergic Synapse PDZ Domain Binding Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Synapse Cell Projection Microtubule-based Process Intracellular Protein Localization Regulation Of Membrane Potential Positive Regulation Of Cellular Component Biogenesis Vocalization Behavior Neurotransmitter Secretion Learning Cellular Component Assembly Protein Localization To Cell Junction Social Behavior Cell Adhesion Presynaptic Membrane Microtubule Cytoskeleton Organization Protein Localization To Synapse Regulation Of Cytoskeleton Organization Cytoskeleton Organization Chemical Synaptic Transmission Neurotransmitter Transport Regulation Of System Process Cell-cell Junction Regulation Of Transport MPP7-DLG1-LIN7 Complex Trans-synaptic Signaling Learning Or Memory Regulation Of Monoatomic Ion Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Signaling Establishment Or Maintenance Of Cell Polarity Signal Release Regulation Of Exosomal Secretion Regulation Of Multicellular Organismal Process Voltage-gated Potassium Channel Complex Postsynaptic Membrane Plasma Membrane Neuromuscular Junction Presynapse Protein Kinase Binding Regulation Of Biological Quality Bicellular Tight Junction Protein Localization To Membrane
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