CDC14A and CDC6

Number of citations: 30 (PubMedID 22117071)
Data Source: BioGRID (enzymatic study)

		CDC14A	CDC6
Name		cell division cycle 14A	cell division cycle 6
Structure		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Stereocilium Stereocilium Tip Cell Projection Kinocilium Mitotic Spindle Kinociliary Basal Body	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Cytosol Intercellular Bridge Spindle Midzone Mitotic Spindle
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity	Nucleotide Binding Chromatin Binding DNA Replication Origin Binding Protein Binding ATP Binding Protein Serine/threonine Kinase Binding
	Biological Process	Microtubule Cytoskeleton Organization Regulation Of Exit From Mitosis Sensory Perception Of Sound Positive Regulation Of Cytokinesis Cell Division Cilium Assembly	DNA Replication Checkpoint Signaling Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Replication DNA Replication Initiation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Mitotic DNA Replication Checkpoint Signaling Positive Regulation Of Fibroblast Proliferation Cell Division Positive Regulation Of Chromosome Segregation Cellular Response To Vasopressin Cellular Response To Angiotensin
Pathways		Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase MAPK6/MAPK4 signaling	Transcription of E2F targets under negative control by DREAM complex Activation of ATR in response to replication stress CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription
GWAS		Estimated glomerular filtration rate ( 31015462 31152163 ) Fasting glucose ( 34059833 ) Fever and diarrhea in mesalamine-treated irritable bowel disease ( 33501934 ) Systolic blood pressure x educational attainment (some college) interaction (2df) ( 32372009 )	Asthma ( 31619474 )
Novel Interactors		None recorded	1 novel interactors: DSC2
Interacting Genes		16 interacting genes: AATK ATPAF2 BRAP C14orf119 CDC25B CDC6 CHRM1 FZR1 KIF20A LMTK2 PLK1 POLR2A PTK7 ROR2 TP53 WEE1	40 interacting genes: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CDC14A CDC20 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FAM13A-AS1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC OGT ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PLK1 PPP2R3A PPP2R3B PSKH1 RPS27A SQSTM1 TERF1 UBC UBE2K UBR1
Entrez ID		8556	990
HPRD ID		04614	04022
Ensembl ID		ENSG00000079335	ENSG00000094804
Uniprot IDs		A0A0U1RQX7 B4DY86 Q59EF4 Q9UNH5	Q99741
PDB IDs		Not available	2CCH 2CCI 4I5L 4I5N 8HT7 8RWV 8S0E
GO Terms Enriched among Interactors		Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cytokinesis Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Process Protein Kinase Activity ATP Binding Negative Regulation Of Cell Cycle Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Regulation Of Cell Division Cell Cycle G2/M Phase Transition Regulation Of Cell Cycle Anaphase-promoting Complex Binding Mitotic DNA Damage Checkpoint Signaling Cell Division Mitotic Nuclear Membrane Disassembly Positive Regulation Of Ubiquitin-protein Transferase Activity Nuclear Membrane Disassembly Positive Regulation Of Mitotic Cell Cycle Phase Transition Membrane Disassembly DNA Damage Checkpoint Signaling Positive Regulation Of Cell Cycle Phase Transition Regulation Of DNA Replication Kinase Activity Positive Regulation Of Mitotic Cell Cycle Protein Tyrosine Kinase Activity Negative Regulation Of DNA Replication Negative Regulation Of DNA Metabolic Process Spindle Midzone Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Spindle Pole Positive Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition	DNA Replication Initiation DNA Replication Regulation Of DNA Replication Nucleoplasm DNA Metabolic Process DNA Replication Origin Binding Nuclear Origin Of Replication Recognition Complex Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Chromosome, Telomeric Region Regulation Of Cell Cycle Process Origin Recognition Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Nucleic Acid Metabolic Process Regulation Of DNA-templated DNA Replication Initiation Mitotic Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Cell Cycle G1/S Phase Transition Cell Division Regulation Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cellular Response To Stress Negative Regulation Of Cell Cycle Process DNA Damage Response Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Fibroblast Proliferation Cell Cycle G2/M Phase Transition Protein Modification Process Positive Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Signaling Regulation Of Primary Metabolic Process Chromosome Positive Regulation Of DNA Replication Regulation Of DNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Fibroblast Proliferation Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Nucleolus