CDC14A and CHRM1

Number of citations of the paper that reports this interaction (PubMedID 22117071)
30

Data Source:
BioGRID (enzymatic study)

		CDC14A	CHRM1
Description		cell division cycle 14A	cholinergic receptor muscarinic 1
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Stereocilium Stereocilium Tip Cell Projection Kinocilium Mitotic Spindle Kinociliary Basal Body	Plasma Membrane Membrane Dendrite Asymmetric Synapse Presynaptic Membrane Axon Terminus Synapse Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse Cholinergic Synapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity
	Biological Process	Microtubule Cytoskeleton Organization Regulation Of Exit From Mitosis Sensory Perception Of Sound Positive Regulation Of Cytokinesis Cell Division Cilium Assembly	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Neuromuscular Synaptic Transmission Nervous System Development Regulation Of Locomotion Positive Regulation Of Monoatomic Ion Transport Saliva Secretion Cognition Regulation Of Postsynaptic Membrane Potential Regulation Of Glial Cell Proliferation Positive Regulation Of Intracellular Protein Transport Acetylcholine Receptor Signaling Pathway Postsynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase MAPK6/MAPK4 signaling	Muscarinic acetylcholine receptors G alpha (q) signalling events
Drugs			Cevimeline Tramadol Trospium Oxyphenonium Benzatropine Ziprasidone Disopyramide Amitriptyline Ipratropium Olanzapine Metixene Terfenadine Buclizine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Profenamine Loxapine Carbamoylcholine Promazine Hyoscyamine Cyproheptadine Meperidine Imipramine Methscopolamine bromide Chlorpromazine Gallamine triethiodide Darifenacin Tridihexethyl Triflupromazine Anisotropine methylbromide Nortriptyline Amoxapine Amoxapine Cinnarizine Atropine Nicardipine Pirenzepine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Clidinium Propiomazine Propantheline Dicyclomine Minaprine Tropicamide Biperiden Brompheniramine Flupentixol Cocaine Maprotiline Methantheline Cycrimine Cyclopentolate Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Flavoxate Desipramine Escitalopram Ketamine Quetiapine Diphenidol Metoclopramide Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Molindone Staurosporine Acetylcholine Arecoline Mepenzolate NGX267 ALKS 27 Norclozapine Pizotifen Fesoterodine Methacholine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Viloxazine Etoperidone Imidafenacin Pyrantel Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462 31152163) Fasting glucose ( 34059833) Fever and diarrhea in mesalamine-treated irritable bowel disease ( 33501934) Systolic blood pressure x educational attainment (some college) interaction (2df) ( 32372009)	Urate levels ( 31578528)
Interacting Genes		16 interacting genes: AATK ATPAF2 BRAP C14orf119 CDC25B CDC6 CHRM1 FZR1 KIF20A LMTK2 PLK1 POLR2A PTK7 ROR2 TP53 WEE1	5 interacting genes: CDC14A GNAI2 GPRASP1 GPRASP2 RGS7
Entrez ID		8556	1128
HPRD ID		04614	00338
Ensembl ID		ENSG00000079335	ENSG00000168539
Uniprot IDs		A0A0U1RQX7 B4DY86 Q59EF4 Q9UNH5	P11229 Q53XZ3
PDB IDs			5CXV 6OIJ 6WJC 6ZFZ 6ZG4 6ZG9
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cytokinesis Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Process Protein Kinase Activity ATP Binding Negative Regulation Of Cell Cycle Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Regulation Of Cell Division Cell Cycle G2/M Phase Transition Regulation Of Cell Cycle Anaphase-promoting Complex Binding Mitotic DNA Damage Checkpoint Signaling Cell Division Mitotic Nuclear Membrane Disassembly Positive Regulation Of Ubiquitin-protein Transferase Activity Nuclear Membrane Disassembly Positive Regulation Of Mitotic Cell Cycle Phase Transition Membrane Disassembly DNA Damage Checkpoint Signaling Positive Regulation Of Cell Cycle Phase Transition Regulation Of DNA Replication Kinase Activity Positive Regulation Of Mitotic Cell Cycle Protein Tyrosine Kinase Activity Negative Regulation Of DNA Replication Negative Regulation Of DNA Metabolic Process Spindle Midzone Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Spindle Pole Positive Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition	Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein-coupled Receptor Catabolic Process Kinociliary Basal Body Negative Regulation Of Signal Transduction Purinergic Nucleotide Receptor Signaling Pathway Guanyl Nucleotide Binding Regulation Of Urine Volume Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway GTPase Activity Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Superoxide Anion Generation Positive Regulation Of Urine Volume G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Superoxide Anion Generation Neuronal Dense Core Vesicle Negative Regulation Of Cell Communication Cell Division G Protein-coupled Adenosine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Signaling Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cytosol Cell Tip Dendrite Terminus G-protein Beta-subunit Binding Kinocilium Stereocilium Tip Regulation Of Exit From Mitosis Receptor Catabolic Process Dendrite Gamma-aminobutyric Acid Signaling Pathway Regulation Of Superoxide Metabolic Process G-protein Alpha-subunit Binding Hematopoietic Stem Cell Homeostasis
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