CDC14A and FZR1

Number of citations of the paper that reports this interaction (PMID 11598127)
28

Data Source:
HPRD (in vitro)

		CDC14A	FZR1
Gene Name		cell division cycle 14A	fizzy/cell division cycle 20 related 1 (Drosophila)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Spindle	Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity	Protein Binding
	Biological Process	Cell Cycle Cell Proliferation Peptidyl-tyrosine Dephosphorylation Cell Division	Mitotic Cell Cycle DNA Repair Mitotic Nuclear Division Positive Regulation Of Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process G2 DNA Damage Checkpoint Regulation Of Meiosis Positive Regulation Of Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Activation Of Anaphase-promoting Complex Activity Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Negative Regulation Of Cell Aging
Pathways		Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of mitotic cell cycle Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Cellular Senescence Phosphorylation of Emi1 Orc1 removal from chromatin Autodegradation of Cdh1 by Cdh1:APC/C Class I MHC mediated antigen processing & presentation Removal of licensing factors from origins Switching of origins to a post-replicative state Synthesis of DNA Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of DNA replication Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase S Phase Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins Orc1 removal from chromatin SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle Cyclin A:Cdk2-associated events at S phase entry Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: BRAP CDC25B CDC6 CHRM1 FZR1 KIF20A POLR2A TP53	42 interactors: ANAPC1 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B C7orf25 CCNA2 CCNB1 CDC14A CDC20 CDC25A CDC27 CDC6 CDK1 CDK2 CDR2 CDT1 CLSPN DNAJA1 E2F3 FBXO5 HECW2 MAK MAPK8 MOAP1 PLK1 PTEN PTTG1 RBBP8 SIRT2 SKIL SKP2 SOX2 TK1 TP53 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2S
Entrez ID		8556	51343
HPRD ID		04614	04687
Ensembl ID		ENSG00000079335
Uniprot IDs		F5H7B3 Q59EF4 Q9UNH5	Q9UM11
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Process Positive Regulation Of Cell Cycle Mitotic Cell Cycle Regulation Of Cell Cycle Cell Division Cell Cycle Process Regulation Of Cell Cycle Process Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of Cell Proliferation Cell Cycle Checkpoint Regulation Of Cell Division Positive Regulation Of Cytokinesis Negative Regulation Of DNA Replication Mitotic Nuclear Division Regulation Of Cytokinesis DNA Metabolic Process Regulation Of Mitotic Cell Cycle Nucleotide-excision Repair Negative Regulation Of DNA Metabolic Process Negative Regulation Of Macromitophagy Transcription, RNA-templated Oligodendrocyte Apoptotic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of DNA Replication Positive Regulation Of Cell Division DNA Repair Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Helicase Activity Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway DNA Damage Checkpoint Cell Proliferation Traversing Start Control Point Of Mitotic Cell Cycle Organelle Organization Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Cell Aging Positive Regulation Of Cell Proliferation Cellular Response To DNA Damage Stimulus Mitochondrial DNA Repair Activation Of Anaphase-promoting Complex Activity Regulation Of Mitotic Cell Cycle Phase Transition Ras Protein Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Positive Regulation Of Protein Modification Process	Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cell Cycle Cell Cycle Process Regulation Of Chromosome Segregation Mitotic Nuclear Division Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Cell Division Modification-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Cell Cycle Checkpoint Positive Regulation Of Ligase Activity Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Cellular Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Cell Cycle Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Cellular Macromolecule Catabolic Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Mitotic Cell Cycle Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Chromosome Organization Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Chromosome Segregation Negative Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		adhesion agilent bioinformatics cdkn1c cdkn2a clustering col6a3 ctnna3 cycles david differentially distinctly dysregulated experiment focal folds go hoxb4 hyperplastic itgb6 oligonucletide pairs regulated repeating resources scar scars tgfbeta1 twice	anaphase cdc20 cdh1 chromosomes clathrin clta cltc concentrated diffusely g2 gst interactor kinetochore localize mad2b mad2l2 misaligned mitotic p11 prcc pull q21 rccs redistribution shuttle spindle tfe3 trimeric triskelion
Tagcloud (Difference) ?		adhesion agilent bioinformatics cdkn1c cdkn2a clustering col6a3 ctnna3 cycles david differentially distinctly dysregulated experiment focal folds go hoxb4 hyperplastic itgb6 oligonucletide pairs regulated repeating resources scar scars tgfbeta1 twice	anaphase cdc20 cdh1 chromosomes clathrin clta cltc concentrated diffusely g2 gst interactor kinetochore localize mad2b mad2l2 misaligned mitotic p11 prcc pull q21 rccs redistribution shuttle spindle tfe3 trimeric triskelion
Tagcloud (Intersection) ?