CDC14A and LMTK2

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		CDC14A	LMTK2
Description		cell division cycle 14A	lemur tyrosine kinase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Stereocilium Stereocilium Tip Cell Projection Kinocilium Mitotic Spindle Kinociliary Basal Body	Cytoplasm Early Endosome Golgi Apparatus Endomembrane System Membrane Growth Cone Neuronal Cell Body Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Phosphatase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Myosin VI Binding Protein Serine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Regulation Of Exit From Mitosis Sensory Perception Of Sound Positive Regulation Of Cytokinesis Cell Division Cilium Assembly	Receptor Recycling Protein Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Endocytic Recycling Transferrin Transport Early Endosome To Late Endosome Transport Protein Autophosphorylation
Pathways		Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase MAPK6/MAPK4 signaling
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462 31152163) Fasting glucose ( 34059833) Fever and diarrhea in mesalamine-treated irritable bowel disease ( 33501934) Systolic blood pressure x educational attainment (some college) interaction (2df) ( 32372009)	Gamma glutamyl transferase levels ( 29403010 33339817) Hemoglobin levels ( 32327693) Prostate cancer ( 18264097) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Interacting Genes		16 interacting genes: AATK ATPAF2 BRAP C14orf119 CDC25B CDC6 CHRM1 FZR1 KIF20A LMTK2 PLK1 POLR2A PTK7 ROR2 TP53 WEE1	24 interacting genes: CDC14A CDC25C CDK5 CDK5R1 DUSP14 DUSP19 DUSP29 DUSP6 ILKAP MTMR6 PPM1A PPM1F PPM1K PPP1CA PPP1CB PPP1CC PPP1R2 PPP3CB PTPDC1 PTPN12 PTPN6 PTPRR STYX TPTE2
Entrez ID		8556	22853
HPRD ID		04614	13994
Ensembl ID		ENSG00000079335	ENSG00000164715
Uniprot IDs		A0A0U1RQX7 B4DY86 Q59EF4 Q9UNH5	Q8IWU2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cytokinesis Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Process Protein Kinase Activity ATP Binding Negative Regulation Of Cell Cycle Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Regulation Of Cell Division Cell Cycle G2/M Phase Transition Regulation Of Cell Cycle Anaphase-promoting Complex Binding Mitotic DNA Damage Checkpoint Signaling Cell Division Mitotic Nuclear Membrane Disassembly Positive Regulation Of Ubiquitin-protein Transferase Activity Nuclear Membrane Disassembly Positive Regulation Of Mitotic Cell Cycle Phase Transition Membrane Disassembly DNA Damage Checkpoint Signaling Positive Regulation Of Cell Cycle Phase Transition Regulation Of DNA Replication Kinase Activity Positive Regulation Of Mitotic Cell Cycle Protein Tyrosine Kinase Activity Negative Regulation Of DNA Replication Negative Regulation Of DNA Metabolic Process Spindle Midzone Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Spindle Pole Positive Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Dephosphorylation Hydrolase Activity Cation Binding Phosphate-containing Compound Metabolic Process Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Phosphatase Activity PTW/PP1 Phosphatase Complex Protein Modification Process Glycogen Metabolic Process Cytoplasm Negative Regulation Of MAPK Cascade Peptidyl-tyrosine Dephosphorylation Energy Reserve Metabolic Process Polysaccharide Metabolic Process Entrainment Of Circadian Clock By Photoperiod Protein Kinase 5 Complex Photoperiodism Entrainment Of Circadian Clock Cytosol MAPK Cascade Rhythmic Process Cell Division Protein Kinase Binding Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Circadian Regulation Of Gene Expression Energy Derivation By Oxidation Of Organic Compounds Non-membrane Spanning Protein Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Nucleoplasm Protein Metabolic Process Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Phosphatase Activity Layer Formation In Cerebral Cortex Negative Regulation Of Intracellular Signal Transduction Regulation Of Circadian Rhythm Protein Phosphatase 1 Binding Positive Regulation Of Protein Targeting To Membrane Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Localization Negative Regulation Of Signaling Regulation Of Establishment Of Protein Localization
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