NKD2 and TGFA

Number of citations of the paper that reports this interaction (PMID 15064403)
22

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		NKD2	TGFA
Gene Name		naked cuticle homolog 2 (Drosophila)	transforming growth factor, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic Membrane-bounded Vesicle Basolateral Plasma Membrane Lateral Plasma Membrane Cytoplasmic Vesicle Cell Periphery	Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Calcium Ion Binding Protein Binding Growth Factor Binding Ubiquitin Protein Ligase Binding	Glycoprotein Binding Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Exocytosis Positive Regulation Of Protein Processing Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Golgi Vesicle Fusion To Target Membrane Protein Targeting To Plasma Membrane Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway	Activation Of MAPK Activity Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Wound Healing Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Proliferation Mammary Gland Alveolus Development
Pathways
Drugs
Diseases
GWAS			Longevity ( 20834067) Neutrophil count ( 21507922) Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: ANAPC11 CDKN1A FUS GRB2 LNX1 RCHY1 TGFA VDR	15 interactors: ADAM10 ADAM17 EGFR ELANE ERBB2 ERBB4 GORASP1 GORASP2 MAGI2 MAGI3 NKD2 RHBDF1 SDCBP SGTA SNTA1
Entrez ID		85409	7039
HPRD ID		08483	07522
Ensembl ID		ENSG00000145506	ENSG00000163235
Uniprot IDs		Q969F2	E7EPT6 F8VNR3 P01135
PDB IDs			1GK5 1MOX 1YUF 1YUG 2TGF 3E50 3TGF 4TGF
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Modification Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Response To Ionizing Radiation Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of ERBB Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction In Response To DNA Damage Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Vitamin D Receptor Signaling Pathway Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Protein Ubiquitination Regulation Of Mitotic Nuclear Division Protein Modification By Small Protein Conjugation Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Phosphatidylinositol-mediated Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Radiation Positive Regulation Of Catalytic Activity Positive Regulation Of Vitamin D 24-hydroxylase Activity Bile Acid Signaling Pathway Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Ionizing Radiation Negative Regulation Of Mitotic Cell Cycle Phase Transition Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Mitotic Cell Cycle Checkpoint Fibroblast Growth Factor Receptor Signaling Pathway Mammary Gland Development Intestinal Epithelial Cell Maturation Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Placenta Development Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Cellular Response To Extracellular Stimulus Neurotrophin TRK Receptor Signaling Pathway	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Locomotion Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component PMA-inducible Membrane Protein Ectodomain Proteolysis Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Component Movement Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Proliferation Cell Migration Positive Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Collagen Catabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Growth Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of T Cell Chemotaxis Regulation Of Cell Proliferation Collagen Metabolic Process Regulation Of ERBB Signaling Pathway Positive Regulation Of Catalytic Activity Multicellular Organismal Macromolecule Metabolic Process Cellular Response To Growth Factor Stimulus Generation Of Neurons Regulation Of Cell Migration Multicellular Organismal Metabolic Process
Tagcloud ?		advance alteration compelling cuticle decreasing diminishes doi downregulation drastically driving engineered enhances genetically homolog localized metastatic migratory naked onc oncogene online os osteoblast osteosarcoma overexpressing propensity publication vessel wnt	alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfb3 thra1 transforming transmission trios utilizing
Tagcloud (Difference) ?		advance alteration compelling cuticle decreasing diminishes doi downregulation drastically driving engineered enhances genetically homolog localized metastatic migratory naked onc oncogene online os osteoblast osteosarcoma overexpressing propensity publication vessel wnt	alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfb3 thra1 transforming transmission trios utilizing
Tagcloud (Intersection) ?