NKD2 and VDR

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NKD2	VDR
Gene Name		naked cuticle homolog 2 (Drosophila)	vitamin D (1,25- dihydroxyvitamin D3) receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic Membrane-bounded Vesicle Basolateral Plasma Membrane Lateral Plasma Membrane Cytoplasmic Vesicle Cell Periphery	Nucleus Nucleoplasm Receptor Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	Calcium Ion Binding Protein Binding Growth Factor Binding Ubiquitin Protein Ligase Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Calcitriol Receptor Activity Lithocholic Acid Receptor Activity Sequence-specific DNA Binding Retinoid X Receptor Binding Vitamin D Response Element Binding Calcitriol Binding Lithocholic Acid Binding
	Biological Process	Exocytosis Positive Regulation Of Protein Processing Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Golgi Vesicle Fusion To Target Membrane Protein Targeting To Plasma Membrane Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Skeletal System Development Transcription Initiation From RNA Polymerase II Promoter Calcium Ion Transport Cellular Calcium Ion Homeostasis Signal Transduction Lactation Negative Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Vitamin D 24-hydroxylase Activity Bile Acid Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Decidualization Intestinal Absorption Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Regulation Of Calcidiol 1-monooxygenase Activity Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway
Pathways			Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs			Calcitriol Calcidiol Ergocalciferol Cholecalciferol Paricalcitol Dihydrotachysterol Alfacalcidol Calcipotriol 1alpha,25-Dihydroxyl-20-Epi-22-Oxa-24,26,27-Trihomovitamin D3 Seocalcitol Inecalcitol (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 5-{2-[1-(1-METHYL-PROPYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-2-METHYLENE-CYCLOHEXANE-1,3-DIOL 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		8 interactors: ANAPC11 CDKN1A FUS GRB2 LNX1 RCHY1 TGFA VDR	71 interactors: ACTN4 ACVR1 BAG1 CASC4 CCND3 CDCA7L CDK7 CFH CLASRP COPS2 CREBBP CSNK2A1 CXXC5 EIF3I FGR FOS FOXO3 GABARAPL1 GABARAPL2 GNPAT GRIP1 GTF2B HMGN3 HR JUN KDM5A LCOR MAPK1 MAPK3 MED1 MED12 MED14 MMRN2 NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NKD2 NR0B2 NR1H2 NRIP1 NSD1 POU1F1 POU2F1 PPARG PPP1CA PPP2CA PRCP PRKCSH PSMC5 RB1 RNF14 RUNX1 RUNX1T1 RXRA RXRB RXRG SIRT1 SMAD3 SNW1 SRC SRPK1 STAT1 TAF11 TCF3 TDG TRIM24 ZBTB16
Entrez ID		85409	7421
HPRD ID		08483	03463
Ensembl ID		ENSG00000145506	ENSG00000111424
Uniprot IDs		Q969F2	F1D8P8 P11473
PDB IDs			1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3AX8 3AZ1 3AZ2 3AZ3 3B0T 3CS4 3CS6 3KPZ 3M7R 3OGT 3P8X 3TKC 3VHW 4G2I
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Modification Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Response To Ionizing Radiation Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of ERBB Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction In Response To DNA Damage Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Vitamin D Receptor Signaling Pathway Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Protein Ubiquitination Regulation Of Mitotic Nuclear Division Protein Modification By Small Protein Conjugation Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Phosphatidylinositol-mediated Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Radiation Positive Regulation Of Catalytic Activity Positive Regulation Of Vitamin D 24-hydroxylase Activity Bile Acid Signaling Pathway Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Ionizing Radiation Negative Regulation Of Mitotic Cell Cycle Phase Transition Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Mitotic Cell Cycle Checkpoint Fibroblast Growth Factor Receptor Signaling Pathway Mammary Gland Development Intestinal Epithelial Cell Maturation Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Placenta Development Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Cellular Response To Extracellular Stimulus Neurotrophin TRK Receptor Signaling Pathway	Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Cell Communication Anatomical Structure Development Signal Transduction Cellular Response To Stimulus Response To Hormone Cellular Metabolic Process Signaling Multicellular Organismal Development Response To Organic Substance
Tagcloud ?		advance alteration compelling cuticle decreasing diminishes doi downregulation drastically driving engineered enhances genetically homolog localized metastatic migratory naked onc oncogene online os osteoblast osteosarcoma overexpressing propensity publication vessel wnt	3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 rho seemed steps takes tc10
Tagcloud (Difference) ?		advance alteration compelling cuticle decreasing diminishes doi downregulation drastically driving engineered enhances genetically homolog localized metastatic migratory naked onc oncogene online os osteoblast osteosarcoma overexpressing propensity publication vessel wnt	3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 rho seemed steps takes tc10
Tagcloud (Intersection) ?