NKD2 and VDR

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NKD2	VDR
Description		NKD inhibitor of Wnt signaling pathway 2	vitamin D receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Cytoplasmic Vesicle Exocytic Vesicle Cell Periphery	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Calcium Ion Binding Protein Binding Growth Factor Binding Ubiquitin Protein Ligase Binding Myosin Heavy Chain Binding Metal Ion Binding ATPase Binding Molecular Adaptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Vitamin D Binding Protein Binding Zinc Ion Binding Bile Acid Nuclear Receptor Activity Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Vitamin D Response Element Binding Calcitriol Binding Lithocholic Acid Binding
	Biological Process	Exocytosis Positive Regulation Of Protein Processing Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Golgi Vesicle Fusion To Target Membrane Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Skeletal System Development Regulation Of DNA-templated Transcription Calcium Ion Transport Intracellular Calcium Ion Homeostasis Lactation Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Cell Differentiation Positive Regulation Of Bone Mineralization Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Phosphate Ion Transmembrane Transport Nuclear Receptor-mediated Bile Acid Signaling Pathway MRNA Transcription By RNA Polymerase II Cell-cell Junction Maintenance Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Decidualization Retinoic Acid Receptor Signaling Pathway Intestinal Absorption Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Response To Bile Acid Negative Regulation Of Phosphate Transmembrane Transport
Pathways			Vitamin D (calciferol) metabolism Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs			Calcitriol Calcifediol Ergocalciferol Cholecalciferol Paricalcitol Dihydrotachysterol Alfacalcidol Calcipotriol Lexacalcitol Seocalcitol Cholesterol Inecalcitol Becocalcidiol CTA018 Eldecalcitol Elocalcitol Doxercalciferol (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) Vitamin D Curcumin Curcumin sulfate
Diseases			Tuberculosis Localized autosomal recessive hypotrichosis
GWAS		Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mean corpuscular hemoglobin concentration ( 32888494) Pancreatic cancer ( 25086665) QT interval ( 24952745) Red cell distribution width ( 27863252 28957414 32888494)	Asthma (adult onset) ( 31036433) Basal cell carcinoma ( 33549134) Eosinophil percentage of white cells ( 32888494) Gout ( 22179738) Gut microbiota (beta diversity) ( 27723756) Inflammatory bowel disease ( 23128233) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Menarche (age at onset) ( 25231870) Serum immune biomarker levels ( 32066700)
Interacting Genes		13 interacting genes: ANAPC11 CDKN1A FBXO7 FUS FXR1 FXR2 GRB2 LNX1 RCHY1 SNCA TGFA TSC1 VDR	79 interacting genes: ACTN4 ACVR1 ANKRD11 BAG1 CCND3 CDCA7L CDK7 CFH CLASRP COPS2 CREBBP CSNK2A1 CXXC5 FGR FOS FOXO3 GABARAPL1 GABARAPL2 GNPAT GOLM2 GRIP1 GTF2B HMGN3 HR JUN KDM5A LCOR MAPK1 MAPK3 MED1 MED14 MED23 MEOX2 MMRN2 MYC NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NKD2 NR0B2 NR1H2 NRIP1 NSD1 NTAQ1 OTUD4 POLR2A POU1F1 POU2F1 PPARG PPP1CA PPP2CA PRCP PRKCSH PRKN PSMC5 RB1 RNF14 RPS6KC1 RUNX1 RUNX1T1 RXRA RXRB RXRG SIRT1 SMAD3 SNW1 SRC SRPK1 STAT1 TAF11 TDG TRIM24 TRIP13 UBR5 ZBTB16
Entrez ID		85409	7421
HPRD ID		08483	03463
Ensembl ID		ENSG00000145506	ENSG00000111424
Uniprot IDs		Q969F2	A0A5K1VW50 F1D8P8 P11473
PDB IDs			1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3AX8 3AZ1 3AZ2 3AZ3 3B0T 3CS4 3CS6 3KPZ 3M7R 3OGT 3P8X 3TKC 3VHW 3W0A 3W0C 3W0Y 3WGP 3WWR 3X31 3X36 4G2I 4ITE 4ITF 5GT4 5V39 5YSY 5YT2 7QPP 8IQN 8IQT
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Postsynapse Ubiquitin-protein Transferase Activity Positive Regulation Of Catabolic Process Cytoplasm Translation Regulator Activity Regulation Of Oxidative Phosphorylation MRNA 3'-UTR Binding Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Catabolic Process Dentate Gyrus Development Regulation Of Aerobic Respiration Amyloid Fibril Formation Nucleus Zinc Ion Binding Regulation Of Biological Quality Cell Cortex Epidermal Growth Factor Receptor Binding Post-translational Protein Modification Positive Regulation Of Metabolic Process Cell Junction Organization Protein Kinase Inhibitor Activity Regulation Of Mitotic Cell Cycle Regulation Of Protein Metabolic Process Protein Sequestering Activity Regulation Of MRNA Stability Regulation Of RNA Stability Molecular Condensate Scaffold Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Organelle Organization L-allo-threonine Aldolase Activity Regulation Of Cellular Respiration Response To Desipramine Presynapse Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Synaptic Plasticity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Hsp70 Protein Binding Positive Regulation Of Mitotic Nuclear Division Memory T Cell Differentiation Calcitriol Binding Lithocholic Acid Binding Presynaptic Modulation Of Chemical Synaptic Transmission Glial Cytoplasmic Inclusion	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Nuclear Receptor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Retinoic Acid Receptor Signaling Pathway Nuclear Retinoic Acid Receptor Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding Hormone-mediated Signaling Pathway Transcription Coactivator Activity Transcription Corepressor Activity Nucleobase-containing Compound Biosynthetic Process DNA-binding Transcription Factor Binding Intracellular Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Metabolic Process Regulation Of MiRNA Transcription Peroxisome Proliferator Activated Receptor Signaling Pathway MRNA Transcription
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