NKD2 and ANAPC11

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NKD2	ANAPC11
Gene Name		naked cuticle homolog 2 (Drosophila)	anaphase promoting complex subunit 11
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic Membrane-bounded Vesicle Basolateral Plasma Membrane Lateral Plasma Membrane Cytoplasmic Vesicle Cell Periphery	Nucleoplasm Anaphase-promoting Complex Nucleolus Cytosol
	Molecular Function	Calcium Ion Binding Protein Binding Growth Factor Binding Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity Cullin Family Protein Binding
	Biological Process	Exocytosis Positive Regulation Of Protein Processing Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Golgi Vesicle Fusion To Target Membrane Protein Targeting To Plasma Membrane Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway	Mitotic Cell Cycle Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination
Pathways			Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ANAPC11 CDKN1A FUS GRB2 LNX1 RCHY1 TGFA VDR	27 interactors: ANAPC1 ANAPC10 ANAPC2 CAPN11 CCNB1 CDC16 CDC25A CDC34 CDH1 CUL5 FBXO5 HECW2 KIF18A MAK MLKL NKD2 PTTG1 RNF111 TRIM65 UBC UBE2C UBE2D1 UBE2D2 UBE2K UBE2S UBE2U ZAP70
Entrez ID		85409	51529
HPRD ID		08483	12452
Ensembl ID		ENSG00000145506	ENSG00000141552
Uniprot IDs		Q969F2	Q9NYG5
PDB IDs
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Modification Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Response To Ionizing Radiation Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of ERBB Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction In Response To DNA Damage Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Vitamin D Receptor Signaling Pathway Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Protein Ubiquitination Regulation Of Mitotic Nuclear Division Protein Modification By Small Protein Conjugation Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Phosphatidylinositol-mediated Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Radiation Positive Regulation Of Catalytic Activity Positive Regulation Of Vitamin D 24-hydroxylase Activity Bile Acid Signaling Pathway Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Ionizing Radiation Negative Regulation Of Mitotic Cell Cycle Phase Transition Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Mitotic Cell Cycle Checkpoint Fibroblast Growth Factor Receptor Signaling Pathway Mammary Gland Development Intestinal Epithelial Cell Maturation Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Placenta Development Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Cellular Response To Extracellular Stimulus Neurotrophin TRK Receptor Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteolysis Mitotic Cell Cycle Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Mitotic Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Catabolic Process Mitotic Nuclear Division Positive Regulation Of Protein Catabolic Process Cell Cycle Process Negative Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Regulation Of Chromosome Segregation Cell Cycle Regulation Of Proteolysis Regulation Of Mitotic Sister Chromatid Separation Protein Metabolic Process Cell Division Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Negative Regulation Of Cellular Protein Catabolic Process
Tagcloud ?		advance alteration compelling cuticle decreasing diminishes doi downregulation drastically driving engineered enhances genetically homolog localized metastatic migratory naked onc oncogene online os osteoblast osteosarcoma overexpressing propensity publication vessel wnt	afg3l2 arf1 calgizzarin cki dci dph2l fb1 fxyd6 gif gp96 gpr85 hhp2 kpdxm ksp mrps7 ohs osteosarcomas ought p110 phosphoglucoisomerase rpl13a rpl35a s11 sec34 skd3 subtracted subtractive sulphonase tapa
Tagcloud (Difference) ?		advance alteration compelling cuticle decreasing diminishes doi downregulation drastically driving engineered enhances genetically homolog localized metastatic migratory naked onc oncogene online os osteoblast osteosarcoma overexpressing propensity publication vessel wnt	afg3l2 arf1 calgizzarin cki dci dph2l fb1 fxyd6 gif gp96 gpr85 hhp2 kpdxm ksp mrps7 ohs osteosarcomas ought p110 phosphoglucoisomerase rpl13a rpl35a s11 sec34 skd3 subtracted subtractive sulphonase tapa
Tagcloud (Intersection) ?