NKD2 and ANAPC11

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NKD2	ANAPC11
Description		NKD inhibitor of Wnt signaling pathway 2	anaphase promoting complex subunit 11
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Cytoplasmic Vesicle Exocytic Vesicle Cell Periphery	Nucleus Nucleoplasm Anaphase-promoting Complex Nucleolus Cytoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex
	Molecular Function	Calcium Ion Binding Protein Binding Growth Factor Binding Ubiquitin Protein Ligase Binding Myosin Heavy Chain Binding Metal Ion Binding ATPase Binding Molecular Adaptor Activity	G Protein-coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin-ubiquitin Ligase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding
	Biological Process	Exocytosis Positive Regulation Of Protein Processing Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Golgi Vesicle Fusion To Target Membrane Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways			Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mean corpuscular hemoglobin concentration ( 32888494) Pancreatic cancer ( 25086665) QT interval ( 24952745) Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		13 interacting genes: ANAPC11 CDKN1A FBXO7 FUS FXR1 FXR2 GRB2 LNX1 RCHY1 SNCA TGFA TSC1 VDR	58 interacting genes: ANAPC10 ANAPC2 BANP BEND2 CAPN11 CCNB1 CDC16 CDC20 CREB5 CRYBA2 CUL5 CYSRT1 DTX2 EFEMP1 EFEMP2 FBXO5 FOXO3 FRS3 FZR1 GPANK1 H2AC4 H2BC3 H3C1 HSD3B7 IQUB KRTAP11-1 KRTAP13-2 KRTAP19-2 KRTAP3-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 MAK MGAT5B MLKL NKD2 OXER1 P4HA3 PRKAA2 PRKAB2 PTTG1 RBPMS RNF111 SPMIP9 TCEANC TLE5 TRIM65 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L1 UBE2S UBE2U WWOX ZAP70
Entrez ID		85409	51529
HPRD ID		08483	12452
Ensembl ID		ENSG00000145506	ENSG00000141552
Uniprot IDs		Q969F2	Q9NYG5
PDB IDs			2MT5 4R2Y 4UI9 5A31 5G04 5G05 5JG6 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Postsynapse Ubiquitin-protein Transferase Activity Positive Regulation Of Catabolic Process Cytoplasm Translation Regulator Activity Regulation Of Oxidative Phosphorylation MRNA 3'-UTR Binding Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Catabolic Process Dentate Gyrus Development Regulation Of Aerobic Respiration Amyloid Fibril Formation Nucleus Zinc Ion Binding Regulation Of Biological Quality Cell Cortex Epidermal Growth Factor Receptor Binding Post-translational Protein Modification Positive Regulation Of Metabolic Process Cell Junction Organization Protein Kinase Inhibitor Activity Regulation Of Mitotic Cell Cycle Regulation Of Protein Metabolic Process Protein Sequestering Activity Regulation Of MRNA Stability Regulation Of RNA Stability Molecular Condensate Scaffold Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Organelle Organization L-allo-threonine Aldolase Activity Regulation Of Cellular Respiration Response To Desipramine Presynapse Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Synaptic Plasticity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Hsp70 Protein Binding Positive Regulation Of Mitotic Nuclear Division Memory T Cell Differentiation Calcitriol Binding Lithocholic Acid Binding Presynaptic Modulation Of Chemical Synaptic Transmission Glial Cytoplasmic Inclusion	Protein Polyubiquitination Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Protein Modification By Small Protein Conjugation Anaphase-promoting Complex Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Protein Modification Process Positive Regulation Of Ubiquitin Protein Ligase Activity Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Anaphase-promoting Complex Binding Regulation Of Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Meiotic Cell Cycle Proteasomal Protein Catabolic Process Intermediate Filament Macromolecule Catabolic Process Proteolysis Free Ubiquitin Chain Polymerization Regulation Of Sister Chromatid Segregation Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Sister Chromatid Separation Ubiquitin-protein Transferase Activity Cell Division Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Regulation Of Chromosome Segregation Regulation Of Chromosome Separation Protein Catabolic Process Regulation Of Nuclear Division Protein Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Metaphase/anaphase Transition Cytosol Cell Cycle Phase Transition Regulation Of Post-translational Protein Modification Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitotic Metaphase/anaphase Transition Protein Branched Polyubiquitination Ubiquitin-like Protein Transferase Activity Regulation Of Reproductive Process Positive Regulation Of Cell Cycle Phase Transition SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Sister Chromatid Separation
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