NKD2 and SHMT2

Data Source: HiPPIP (Novel)

		NKD2	SHMT2
Name		NKD inhibitor of Wnt signaling pathway 2	serine hydroxymethyltransferase 2
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Cytoplasmic Vesicle Exocytic Vesicle Cell Periphery	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Microtubule Cytoskeleton Membrane Mitochondrial Nucleoid Intracellular Organelle Lumen Extracellular Exosome BRISC Complex
	Molecular Function	Calcium Ion Binding Protein Binding Growth Factor Binding Ubiquitin Protein Ligase Binding Myosin Heavy Chain Binding Metal Ion Binding ATPase Binding Molecular Adaptor Activity	Chromatin Binding Glycine Hydroxymethyltransferase Activity Protein Binding L-allo-threonine Aldolase Activity Amino Acid Binding Transferase Activity Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Exocytosis Positive Regulation Of Protein Processing Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Golgi Vesicle Fusion To Target Membrane Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane	Regulation Of Oxidative Phosphorylation Regulation Of Translation Glycine Metabolic Process Glycine Biosynthetic Process L-serine Metabolic Process L-serine Biosynthetic Process One-carbon Metabolic Process Positive Regulation Of Cell Population Proliferation Formate Biosynthetic Process Glycine Biosynthetic Process From Serine Response To Type I Interferon Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Protein Tetramerization Protein Homotetramerization Regulation Of Mitochondrial Translation Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration
Pathways		None	Metabolism of folate and pterines RHOG GTPase cycle Mitochondrial protein degradation
Drugs		None	Pyridoxal phosphate Tetrahydrofolic acid Glycine Artenimol
GWAS		Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Pancreatic cancer ( 25086665 ) QT interval ( 24952745 ) Red cell distribution width ( 27863252 28957414 32888494 )	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Asthma ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Schizophrenia ( 25056061 29483656 )
Novel Interactors		1 novel interactors: SHMT2	9 novel interactors: ACVR1B CFTR COMMD6 KMT2D NKD2 PRKAG1 RND1 SCAF11 TUBA1C
Interacting Genes		13 interacting genes: ANAPC11 CDKN1A FBXO7 FUS FXR1 FXR2 GRB2 LNX1 RCHY1 SNCA TGFA TSC1 VDR	15 interacting genes: APP ARL6IP1 BRCC3 CAB39 CLEC2D CMTM5 CREB3 CSNK2B DUX4 ESR1 KASH5 MAL2 NDRG1 OGT PPARD
Entrez ID		85409	6472
HPRD ID		08483	00717
Ensembl ID		ENSG00000145506	ENSG00000182199
Uniprot IDs		Q969F2	B4DJQ3 B4DLV4 P34897 Q5BJF5 V9HW06
PDB IDs		Not available	4PVF 5V7I 5X3V 6DK3 6H3C 6M5O 6QVG 6QVL 6R8F 7BYI 8AQL 8FJT 8FJU 8GKS 8GKT 8GKU 8GKW 8GKY 8GKZ 8QI7 8SSJ 8T4O 8T4P 8TLC 9BOX
GO Terms Enriched among Interactors		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Postsynapse Ubiquitin-protein Transferase Activity Positive Regulation Of Catabolic Process Cytoplasm Translation Regulator Activity Regulation Of Oxidative Phosphorylation MRNA 3'-UTR Binding Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Catabolic Process Dentate Gyrus Development Regulation Of Aerobic Respiration Amyloid Fibril Formation Nucleus Zinc Ion Binding Regulation Of Biological Quality Cell Cortex Epidermal Growth Factor Receptor Binding Post-translational Protein Modification Positive Regulation Of Metabolic Process Cell Junction Organization Protein Kinase Inhibitor Activity Regulation Of Mitotic Cell Cycle Regulation Of Protein Metabolic Process Protein Sequestering Activity Regulation Of MRNA Stability Regulation Of RNA Stability Molecular Condensate Scaffold Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Organelle Organization L-allo-threonine Aldolase Activity Regulation Of Cellular Respiration Response To Desipramine Presynapse Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Synaptic Plasticity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Hsp70 Protein Binding Positive Regulation Of Mitotic Nuclear Division Memory T Cell Differentiation Calcitriol Binding Lithocholic Acid Binding Presynaptic Modulation Of Chemical Synaptic Transmission Glial Cytoplasmic Inclusion	Negative Regulation Of MiRNA Transcription Signal Transduction Release From Viral Latency Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of MiRNA Transcription Neuron Remodeling Regulation Of Purine Nucleotide Metabolic Process Protein Kinase Regulator Activity Regulation Of MiRNA Metabolic Process Peptidyl-threonine Phosphorylation Serine/threonine Protein Kinase Complex Intracellular Signal Transduction Protein Serine/threonine Kinase Binding Positive Regulation Of Monocyte Chemotaxis Nuclear Steroid Receptor Activity Protein-containing Complex Regulation Of Activin Receptor Signaling Pathway Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Regulation Of Cell Population Proliferation Amylin Binding Neuron Maturation Cell Maturation Positive Regulation Of Toll Signaling Pathway Regulation Of Small Molecule Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Protein-containing Complex Assembly Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Monocyte Chemotaxis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus 14-3-3 Protein Binding Developmental Process Involved In Reproduction Cellular Response To Stress Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of Myoblast Differentiation NF-kappaB Binding Linoleic Acid Binding Beta-catenin-TCF Complex Assembly