NKD2

Description		NKD inhibitor of Wnt signaling pathway 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Cytoplasmic Vesicle Exocytic Vesicle Cell Periphery
	Molecular Function	Calcium Ion Binding Protein Binding Growth Factor Binding Ubiquitin Protein Ligase Binding Myosin Heavy Chain Binding Metal Ion Binding ATPase Binding Molecular Adaptor Activity
	Biological Process	Exocytosis Positive Regulation Of Protein Processing Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Golgi Vesicle Fusion To Target Membrane Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases
GWAS		Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mean corpuscular hemoglobin concentration ( 32888494) Pancreatic cancer ( 25086665) QT interval ( 24952745) Red cell distribution width ( 27863252 28957414 32888494)
Novel Interacting Genes		1 novel interacting genes: SHMT2
Interacting Genes		13 interacting genes: ANAPC11 CDKN1A FBXO7 FUS FXR1 FXR2 GRB2 LNX1 RCHY1 SNCA TGFA TSC1 VDR
Entrez ID		85409
HPRD ID		08483
Ensembl ID		ENSG00000145506
Uniprot IDs		Q969F2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Postsynapse Ubiquitin-protein Transferase Activity Positive Regulation Of Catabolic Process Cytoplasm Translation Regulator Activity Regulation Of Oxidative Phosphorylation MRNA 3'-UTR Binding Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Catabolic Process Dentate Gyrus Development Regulation Of Aerobic Respiration Amyloid Fibril Formation Nucleus Zinc Ion Binding Regulation Of Biological Quality Cell Cortex Epidermal Growth Factor Receptor Binding Post-translational Protein Modification Positive Regulation Of Metabolic Process Cell Junction Organization Protein Kinase Inhibitor Activity Regulation Of Mitotic Cell Cycle Regulation Of Protein Metabolic Process Protein Sequestering Activity Regulation Of MRNA Stability Regulation Of RNA Stability Molecular Condensate Scaffold Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Organelle Organization L-allo-threonine Aldolase Activity Regulation Of Cellular Respiration Response To Desipramine Presynapse Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Synaptic Plasticity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Hsp70 Protein Binding Positive Regulation Of Mitotic Nuclear Division Memory T Cell Differentiation Calcitriol Binding Lithocholic Acid Binding Presynaptic Modulation Of Chemical Synaptic Transmission Glial Cytoplasmic Inclusion
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