MLF1 and COPS3

Number of citations: 50 (PubMedID 15861129)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		MLF1	COPS3
Name		myeloid leukemia factor 1	COP9 signalosome subunit 3
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Cilium Ciliary Basal Body Cell Projection Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Protein Binding Protein Domain Specific Binding	Protein Binding
	Biological Process	Myeloid Progenitor Cell Differentiation DNA-templated Transcription Regulation Of DNA-templated Transcription Cell Differentiation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle G1/S Phase Transition	Protein Deneddylation In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Signal Transduction Response To Light Stimulus Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Neddylation Regulation Of Protein Neddylation
Pathways		None	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Depression ( 29700475 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Major depressive disorder ( 27479909 ) PR interval ( 32439900 ) Sporadic neuroblastoma ( 28545128 ) Systolic blood pressure ( 30224653 )	Alanine aminotransferase levels ( 33547301 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Reticulocyte count ( 32888494 )
Novel Interactors		5 novel interactors: CLRN1 GBA1 GMPS RARRES1 RNF13	None recorded
Interacting Genes		9 interacting genes: CENPU COP1 COPS3 DNAJB6 GRIK5 MAGEA11 MEOX2 NRBP1 YWHAZ	32 interacting genes: ARAF ARF4 C17orf75 CEBPA CEBPE COPS2 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CSNK2B CUL5 FLAD1 FRS3 GPS1 IKBKB IKBKG IL1RN IRF5 ITGB2 KRT80 LRP2BP MCPH1 MLF1 NABP1 PRXL2B RAF1 SOS1 TP53 UBC
Entrez ID		4291	8533
HPRD ID		03239	07262
Ensembl ID		ENSG00000178053	ENSG00000141030
Uniprot IDs		A0A0S2Z4A4 A0A0S2Z4U8 A0A140VKD2 A0A494C175 A0A499FJ64 B2RD48 C9JNE5 C9K0D4 P58340 Q2TLE4	B4DN01 Q9UNS2
PDB IDs		3UAL 3UBW 6Y8E	4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F
GO Terms Enriched among Interactors		None	Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Cytosol Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Cytokine-mediated Signaling Pathway Post-translational Protein Modification Protein Modification Process Regulation Of Primary Metabolic Process Cytoplasm Intracellular Signal Transduction Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body ERBB Signaling Pathway Regulation Of Macromolecule Metabolic Process Intracellular Signaling Cassette Regulation Of Ubiquitin-dependent Protein Catabolic Process COP9 Signalosome Assembly Cell Surface Receptor Signaling Pathway Signal Transduction Identical Protein Binding Nucleoplasm DeNEDDylase Activity Regulation Of Proteolysis IkappaB Kinase Complex Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transferrin Receptor Binding Macromolecule Metabolic Process Metal-dependent Deubiquitinase Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Type II Interferon-mediated Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Protein Metabolic Process Protein Heterodimerization Activity Inflammatory Response Protein Phosphorylation Protein Binding Immune Response-activating Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Schwann Cell Development Regulation Of Intracellular Signal Transduction Phosphorylation Protein Serine/threonine Kinase Activity