MLF1 and COP1

Number of citations of the paper that reports this interaction (PubMedID 29296815)
37

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MLF1	COP1
Description		myeloid leukemia factor 1	COP1 E3 ubiquitin ligase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Cilium Ciliary Basal Body Cell Projection Perinuclear Region Of Cytoplasm	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Cul4A-RING E3 Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Protein Binding Protein Domain Specific Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Myeloid Progenitor Cell Differentiation DNA-templated Transcription Regulation Of DNA-templated Transcription Cell Differentiation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle G1/S Phase Transition	Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Autodegradation of the E3 ubiquitin ligase COP1 Neddylation
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Depression ( 29700475) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Major depressive disorder ( 27479909) PR interval ( 32439900) Sporadic neuroblastoma ( 28545128) Systolic blood pressure ( 30224653)	Appendicular lean mass ( 33097823)
Interacting Genes		9 interacting genes: CENPU COP1 COPS3 DNAJB6 GRIK5 MAGEA11 MEOX2 NRBP1 YWHAZ	17 interacting genes: CDKN1B CUL4B DET1 ETS1 ETS2 GATA2 JUN JUND MLF1 PTPN1 RB1CC1 SFN SIPA1 TP53 UBE2D1 UBE2D2 YWHAZ
Entrez ID		4291	64326
HPRD ID		03239	07455
Ensembl ID		ENSG00000178053	ENSG00000143207
Uniprot IDs		A0A0S2Z4A4 A0A0S2Z4U8 A0A140VKD2 A0A494C175 A0A499FJ64 B2RD48 C9JNE5 C9K0D4 P58340 Q2TLE4	Q8NHY2 X5D7N8 X5DNY7
PDB IDs		3UAL 3UBW 6Y8E	5HQG 5IGQ
Enriched GO Terms of Interacting Partners?			Cul4A-RING E3 Ubiquitin Ligase Complex Negative Regulation Of Cell Population Proliferation Ubiquitin Protein Ligase Binding Regulation Of Cell Cycle Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of MiRNA Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Regulation Of MiRNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Response To Antibiotic Regulation Of Primary Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Phosphoserine Residue Binding Transcription Factor AP-1 Complex Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Cycle G1/S Phase Transition DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Repressor Complex Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Antibiotic Negative Regulation Of Protein Kinase Activity DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Kinase Activity Protein Kinase Binding General Transcription Initiation Factor Binding Protein-containing Complex Negative Regulation Of Neuroblast Proliferation Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Transcription Regulator Complex
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