MLF1 and GRIK5

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MLF1	GRIK5
Gene Name		myeloid leukemia factor 1	glutamate receptor, ionotropic, kainate 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Endoplasmic Reticulum Plasma Membrane Postsynaptic Density Cell Junction Dendrite Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane
	Molecular Function	DNA Binding Protein Binding Protein Domain Specific Binding	Extracellular-glutamate-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity SH3 Domain Binding PDZ Domain Binding Identical Protein Binding
	Biological Process	Myeloid Progenitor Cell Differentiation Transcription, DNA-templated Cell Cycle Arrest	Protein Retention In ER Lumen Synaptic Transmission Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Establishment Of Localization In Cell Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Response To Glucose Stimulus
Pathways			Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs			L-Glutamic Acid
Diseases
GWAS			Bipolar disorder ( 21771265)
Protein-Protein Interactions		6 interactors: CENPU COPS3 GRIK5 MAGEA11 NRBP1 YWHAZ	8 interactors: DLG4 GOLM1 GPAA1 GRID2 GRIK2 GRIK3 LRSAM1 MLF1
Entrez ID		4291	2901
HPRD ID		03239	02614
Ensembl ID		ENSG00000178053	ENSG00000105737
Uniprot IDs		B2RD48 P58340 Q2TLE4 Q5HYH4	Q16478
PDB IDs		3UAL 3UBW
Enriched GO Terms of Interacting Partners?		Golgi Reassembly Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Histamine Secretion By Mast Cell Establishment Of Golgi Localization Golgi Inheritance Cullin Deneddylation Histamine Secretion Protein Retention In ER Lumen Protein Deneddylation Maintenance Of Protein Localization In Endoplasmic Reticulum Histamine Transport Golgi Localization Mast Cell Degranulation Protein Localization To Organelle Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Mast Cell Mediated Immunity Establishment Of Localization In Cell CENP-A Containing Nucleosome Assembly Lysosome Localization Positive Regulation Of Apoptotic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Mast Cell Activation Positive Regulation Of Cell Death Histone Exchange Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis DNA Replication-independent Nucleosome Assembly Leukocyte Degranulation Cytoplasmic Transport Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Transport Cellular Localization Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Regulated Secretory Pathway Chordate Embryonic Development Centromere Complex Assembly Embryo Development Ending In Birth Or Egg Hatching	Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Regulation Of Membrane Potential Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Protein Retention In ER Lumen Maintenance Of Protein Localization In Endoplasmic Reticulum Membrane Depolarization Negative Regulation Of Synaptic Transmission, Glutamatergic Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Endocytosis Regulation Of Synaptic Transmission Receptor Clustering Cell-cell Signaling Regulation Of Neuronal Synaptic Plasticity Protein Localization Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Vesicle-mediated Transport Ubiquitin-dependent Endocytosis Positive Regulation Of Synaptic Transmission Cellular Protein Localization Protein Localization To Endoplasmic Reticulum Neuromuscular Process Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Regulation Of Synaptic Plasticity Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Endocytosis Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Vesicle Organization Maintenance Of Apical/basal Cell Polarity Membrane Organization Regulation Of Cellular Component Organization Receptor Localization To Synapse Regulation Of Neuron Apoptotic Process Negative Regulation Of Receptor Internalization Viral Budding Myeloid Progenitor Cell Differentiation Locomotory Exploration Behavior Dendritic Spine Morphogenesis Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Neuron Death Synaptic Vesicle Maturation
Tagcloud ?		akt1 akt2 aurka axon card11 deregulated exclusive exome fgfr2 grouping hook3 integrative massively men1 mutually nets neuroendocrine nono pdgfr preponderance provisional recurrently si smad smad1 snvs therapeutically transitions vhl	abuse bdkrb2 bipolar compulsive confer defines difficulty disorders eating genetics ghrh hint ionotropic kainate neurodevelopment neurotransmission obsessive odd panic preb prolactin psychiatric psychotic releasing rs945032 snps substance susceptibility synonymous
Tagcloud (Difference) ?		akt1 akt2 aurka axon card11 deregulated exclusive exome fgfr2 grouping hook3 integrative massively men1 mutually nets neuroendocrine nono pdgfr preponderance provisional recurrently si smad smad1 snvs therapeutically transitions vhl	abuse bdkrb2 bipolar compulsive confer defines difficulty disorders eating genetics ghrh hint ionotropic kainate neurodevelopment neurotransmission obsessive odd panic preb prolactin psychiatric psychotic releasing rs945032 snps substance susceptibility synonymous
Tagcloud (Intersection) ?