ITGA8 and VTN

Number of citations: 0 (PubMedID 7559467)
Data Source: HPRD (in vitro)

		ITGA8	VTN
Name		integrin subunit alpha 8	vitronectin
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Dendritic Spine Membrane Integrin Alpha8-beta1 Complex Perikaryon Apical Part Of Cell Postsynaptic Density Membrane Glutamatergic Synapse	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Golgi Lumen Symbiont-containing Vacuole Extracellular Matrix Rough Endoplasmic Reticulum Lumen Extracellular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle Protein Complex Involved In Cell-matrix Adhesion Peptidase Inhibitor Complex
	Molecular Function	Signaling Receptor Activity Metal Ion Binding	Scavenger Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Polysaccharide Binding Identical Protein Binding Extracellular Matrix Binding
	Biological Process	Metanephros Development Formation Of Primary Germ Layer Kidney Development Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Nervous System Development Memory Tissue Development Cell Projection Organization Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell-substrate Adhesion Substrate Adhesion-dependent Cell Spreading Inner Ear Morphogenesis Establishment Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Mesodermal Cell Differentiation Smooth Muscle Tissue Development Smooth Muscle Cell Differentiation Cell-cell Adhesion	Immune Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Smooth Muscle Cell Migration Vesicle-mediated Transport Cell Migration Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Negative Regulation Of Proteolysis Positive Regulation Of Receptor-mediated Endocytosis Oligodendrocyte Differentiation Protein Polymerization Negative Regulation Of Fibrinolysis Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing Liver Regeneration Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs ECM proteoglycans Formation of the ureteric bud	Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans ECM proteoglycans Regulation of Complement cascade Developmental Lineage of Pancreatic Ductal Cells
Drugs		None	Abciximab Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
GWAS		Autism spectrum disorders (social interaction) ( 32624584 ) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921 ) Diisocyanate-induced asthma ( 25918132 ) Parkinson's disease ( 19915575 32201043 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Periodontitis (CDC/AAP) ( 24024966 ) Quantitative traits ( 19197348 ) Smoking status (heavy vs never) ( 26423011 )	Advanced age-related macular degeneration ( 26691988 ) Heel bone mineral density ( 30598549 ) LDL cholesterol ( 30275531 ) Low density lipoprotein cholesterol levels ( 32154731 33339817 ) Osteoprotegerin levels ( 25080503 )
Interacting Genes		4 interacting genes: FN1 ITGB1 NPNT VTN	50 interacting genes: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 DLG2 DLG3 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA2B ITGA5 ITGA8 ITGAV ITGB3 ITGB6 ITGB8 KNG1 LACRT LNX2 PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 SNTG1 TGFB1 TGFB2 TNFRSF11B UBQLN2 VEGFA
Entrez ID		8516	7448
HPRD ID		10361	01902
Ensembl ID		ENSG00000077943	ENSG00000109072
Uniprot IDs		B4DN28 P53708	D9ZGG2 P04004
PDB IDs		Not available	1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2 4K24 6O5E 7RJ9
GO Terms Enriched among Interactors		Cell-matrix Adhesion Integrin Binding Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Calcium-independent Cell-matrix Adhesion Basement Membrane Integrin-mediated Signaling Pathway Cell-cell Adhesion Mediated By Integrin Extracellular Matrix Structural Constituent Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Cell Adhesion Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Response To Muscle Activity Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Endodermal Cell Differentiation Regulation Of Cellular Response To Growth Factor Stimulus Extracellular Matrix Positive Regulation Of Signal Transduction Collagen Binding Positive Regulation Of Wound Healing Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Activity Positive Regulation Of Cell Migration Endothelial Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Extracellular Exosome Transforming Growth Factor Beta Receptor Signaling Pathway Protease Binding Myoblast Fate Specification Integrin Alpha7-beta1 Complex Muscle Cell Differentiation Symbiont-containing Vacuole Blood Microparticle Regulation Of Cell Adhesion Cell Differentiation Regulation Of Wound Healing Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex	Platelet Alpha Granule Lumen Integrin Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Integrin Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell-matrix Adhesion Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Locomotion Cell-cell Adhesion Positive Regulation Of Vasculature Development Cell Surface Regulation Of Vesicle-mediated Transport Regulation Of Cell Communication Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Epithelial Tube Formation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Signaling Receptor Binding Negative Regulation Of Multicellular Organismal Process Cell Adhesion Growth Factor Activity Angiogenesis Cell-substrate Adhesion Integrin-mediated Signaling Pathway Cell Adhesion Mediated By Integrin Regulation Of Endocytosis Regulation Of Protein Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Alphav-beta3 Integrin-PKCalpha Complex Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein Localization Regulation Of Vasculature Development Regulation Of Transport Positive Regulation Of Angiogenesis Positive Regulation Of Protein Localization Regulation Of Morphogenesis Of An Epithelium Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of MAPK Cascade Regulation Of Cell Migration Positive Regulation Of Morphogenesis Of An Epithelium