ITGA8

Description		integrin subunit alpha 8
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Dendritic Spine Membrane Integrin Alpha8-beta1 Complex Perikaryon Apical Part Of Cell Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Signaling Receptor Activity Metal Ion Binding
	Biological Process	Metanephros Development Formation Of Primary Germ Layer Kidney Development Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Nervous System Development Memory Tissue Development Cell Projection Organization Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell-substrate Adhesion Substrate Adhesion-dependent Cell Spreading Inner Ear Morphogenesis Establishment Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Mesodermal Cell Differentiation Smooth Muscle Tissue Development Smooth Muscle Cell Differentiation Cell-cell Adhesion
Pathways		Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs ECM proteoglycans Formation of the ureteric bud
Drugs
Diseases
GWAS		Autism spectrum disorders (social interaction) ( 32624584) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Diisocyanate-induced asthma ( 25918132) Parkinson's disease ( 19915575 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Periodontitis (CDC/AAP) ( 24024966) Quantitative traits ( 19197348) Smoking status (heavy vs never) ( 26423011)
Interacting Genes		4 interacting genes: FN1 ITGB1 NPNT VTN
Entrez ID		8516
HPRD ID		10361
Ensembl ID		ENSG00000077943
Uniprot IDs		B4DN28 P53708
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-matrix Adhesion Integrin Binding Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Calcium-independent Cell-matrix Adhesion Basement Membrane Integrin-mediated Signaling Pathway Cell-cell Adhesion Mediated By Integrin Extracellular Matrix Structural Constituent Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Cell Adhesion Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Response To Muscle Activity Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Endodermal Cell Differentiation Regulation Of Cellular Response To Growth Factor Stimulus Extracellular Matrix Positive Regulation Of Signal Transduction Collagen Binding Positive Regulation Of Wound Healing Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Activity Positive Regulation Of Cell Migration Endothelial Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Extracellular Exosome Transforming Growth Factor Beta Receptor Signaling Pathway Protease Binding Myoblast Fate Specification Integrin Alpha7-beta1 Complex Muscle Cell Differentiation Symbiont-containing Vacuole Blood Microparticle Regulation Of Cell Adhesion Cell Differentiation Regulation Of Wound Healing Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex
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