ORAI1 and TRPC3

Number of citations of the paper that reports this interaction (PMID 17360584)
85

Data Source:
HPRD (in vitro, in vivo)

		ORAI1	TRPC3
Gene Name		ORAI calcium release-activated calcium modulator 1	transient receptor potential cation channel, subfamily C, member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Membrane Protein Complex	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Calmodulin Binding Store-operated Calcium Channel Activity Identical Protein Binding	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Store-operated Calcium Entry Immune System Process Blood Coagulation Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport	Calcium Ion Transport Axon Guidance Blood Coagulation Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Platelet Activation Response To ATP Ion Transmembrane Transport Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		Signaling by the B Cell Receptor (BCR) Platelet homeostasis Elevation of cytosolic Ca2+ levels Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Platelet calcium homeostasis Adaptive Immune System	G alpha (q) signalling events Signaling by GPCR Axon guidance TRP channels Effects of PIP2 hydrolysis Platelet calcium homeostasis G alpha (q) signalling events GPCR downstream signaling Ion channel transport Platelet homeostasis Role of second messengers in netrin-1 signaling Gastrin-CREB signalling pathway via PKC and MAPK Elevation of cytosolic Ca2+ levels Stimuli-sensing channels Platelet activation, signaling and aggregation Netrin-1 signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: TRPC3 TRPC6	20 interactors: CALM1 FKBP1A GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2
Entrez ID		84876	7222
HPRD ID		08599	15999
Ensembl ID			ENSG00000138741
Uniprot IDs		Q96D31	J3QTB0 Q13507
PDB IDs		4EHQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Calcium Ion Transport Regulation Of Calcium Ion Transport Platelet Activation Positive Regulation Of Ion Transport Calcium Ion Transmembrane Transport Calcium Ion Transport Axon Guidance Blood Coagulation Hemostasis Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Response To Inorganic Substance Axonogenesis Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Regulation Of Ion Transport Neuron Projection Morphogenesis Cell Activation Response To Wounding Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Neuron Projection Development Metal Ion Transport Cell Projection Morphogenesis Cell Part Morphogenesis Positive Regulation Of Cardiac Muscle Hypertrophy Cation Transmembrane Transport Neuron Development Cell Morphogenesis Response To Abiotic Stimulus Response To ATP Neuron Differentiation Cell Projection Organization Regulation Of Cardiac Muscle Hypertrophy Cation Transport Locomotion Ion Transmembrane Transport Positive Regulation Of Calcium Ion Transport Into Cytosol Movement Of Cell Or Subcellular Component Positive Regulation Of Ion Transmembrane Transporter Activity Generation Of Neurons Positive Regulation Of Transporter Activity Cellular Response To Hydrogen Peroxide Neurogenesis Transmembrane Transport Ion Transport Cell Development	Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Wound Healing Response To Wounding Activation Of Phospholipase C Activity Calcium Ion Transmembrane Transport Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Cell Activation Regulation Of Phospholipase Activity Calcium Ion Transport Positive Regulation Of Lipase Activity Regulation Of Cellular Localization Regulation Of Calcium Ion Transport Platelet Activation Inositol Phosphate Metabolic Process Second-messenger-mediated Signaling Cellular Calcium Ion Homeostasis Regulation Of Ion Homeostasis Calcium Ion Homeostasis Cytosolic Calcium Ion Homeostasis Positive Regulation Of Calcium Ion Transport Synaptic Transmission Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Metal Ion Homeostasis Energy Reserve Metabolic Process Cellular Chemical Homeostasis Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Metal Ion Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Communication Ion Homeostasis Chemical Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Signaling Response To Stimulus Cation Transmembrane Transport Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Ion Transport Response To Fibroblast Growth Factor Regulation Of Calcium Ion Transport Into Cytosol
Tagcloud ?		acinar agonist agonists carboxyl clustering coexpression depleted diminished dispersed glands hek intensities junctions mildly muscarinic nfat operated pm polybasic puncta recruits salivary soce stim1 stim1deltak stim2 stimulus store stores	channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1
Tagcloud (Difference) ?		acinar agonist agonists carboxyl clustering coexpression depleted diminished dispersed glands hek intensities junctions mildly muscarinic nfat pm polybasic puncta recruits salivary soce stim1deltak stimulus stores	channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm patch scarce sensors switch talk trpc1
Tagcloud (Intersection) ?		operated stim1 stim2 store