ORAI1 and TRPC3

Number of citations of the paper that reports this interaction (PubMedID 17360584)
58

Data Source:
HPRD (in vitro, in vivo)

		ORAI1	TRPC3
Description		ORAI calcium release-activated calcium modulator 1	transient receptor potential cation channel subfamily C member 3
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GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Calcium Channel Complex Plasma Membrane Raft Membrane Raft	Plasma Membrane Membrane Cation Channel Complex
	Molecular Function	Calcium Channel Activity Protein Binding Calmodulin Binding Store-operated Calcium Channel Activity Identical Protein Binding	Monoatomic Ion Channel Activity Calcium-activated Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Store-operated Calcium Entry Adaptive Immune Response Immune System Process Monoatomic Ion Transport Calcium Ion Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Insulin Secretion Calcineurin-NFAT Signaling Cascade Monoatomic Ion Transmembrane Transport Positive Regulation Of Adenylate Cyclase Activity Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Mammary Gland Epithelium Development Calcium Ion Import Calcium Ion Transmembrane Transport Ligand-gated Ion Channel Signaling Pathway	Monoatomic Ion Transport Calcium Ion Transport Single Fertilization Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Response To ATP Monoatomic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		Elevation of cytosolic Ca2+ levels Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling MECP2 regulates neuronal receptors and channels
Drugs
Diseases
GWAS		Experiencing mood swings ( 29500382) Major depressive disorder ( 27777418)	Asthma ( 31959851 34103634) Celiac disease and Rheumatoid arthritis ( 26546613) Emphysema imaging phenotypes ( 26030696) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307)
Interacting Genes		2 interacting genes: TRPC3 TRPC6	21 interacting genes: CALM1 FKBP1A FNDC5 GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2
Entrez ID		84876	7222
HPRD ID		08599	15999
Ensembl ID		ENSG00000276045	ENSG00000138741
Uniprot IDs		Q96D31	Q13507
PDB IDs		2MAK 4EHQ	5ZBG 6CUD 6D7L 6DJS 7DXB 7DXC 7DXD 7DXE
Enriched GO Terms of Interacting Partners?		Inositol 1,4,5 Trisphosphate Binding Store-operated Calcium Channel Activity Cation Channel Complex Regulation Of Cytosolic Calcium Ion Concentration Calcium Channel Activity Single Fertilization Positive Regulation Of Calcium Ion Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Fertilization Positive Regulation Of Cytosolic Calcium Ion Concentration Monoatomic Ion Channel Activity Intracellular Calcium Ion Homeostasis Calcium Ion Transmembrane Transport Positive Regulation Of Monoatomic Ion Transport Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Calcium Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Metal Ion Transport Intracellular Monoatomic Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Inorganic Ion Homeostasis Regulation Of Monoatomic Ion Transport Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Chemical Homeostasis Slit Diaphragm Negative Regulation Of Dendrite Morphogenesis Metal Ion Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Calcium-activated Cation Channel Activity Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Cellular Homeostasis Positive Regulation Of Calcium Ion Transport Into Cytosol Inorganic Ion Transmembrane Transport Actinin Binding Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Positive Regulation Of Transport Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Chemical Homeostasis Monoatomic Ion Transport Response To ATP Monoatomic Cation Channel Activity Positive Regulation Of Ion Transmembrane Transporter Activity Clathrin Binding Positive Regulation Of Cardiac Muscle Hypertrophy Transmembrane Transport	Regulation Of Sequestering Of Calcium Ion Calcium Ion Transmembrane Transport Calcium Ion Transport Metal Ion Transport Inositol 1,4,5 Trisphosphate Binding Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Phosphatidylinositol Phospholipase C Activity Negative Regulation Of Sequestering Of Calcium Ion Monoatomic Ion Transport Inorganic Ion Transmembrane Transport Store-operated Calcium Channel Activity Monoatomic Ion Transmembrane Transport Calcium Channel Activity Calcium-mediated Signaling Phospholipase C Activity Regulation Of Metal Ion Transport Regulation Of Transport Regulation Of Calcium Ion Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Insulin Secretion Plasma Membrane Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Calcium Ion Homeostasis Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Intracellular Signal Transduction Positive Regulation Of Transport Calcium Ion Binding Phosphoric Diester Hydrolase Activity Intracellular Signaling Cassette Positive Regulation Of Protein Transport Long-term Synaptic Potentiation Regulation Of Hormone Secretion Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Protein Localization Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion
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