ORAI1 and TRPC6

Number of citations of the paper that reports this interaction (PMID 17360584)
85

Data Source:
HPRD (in vivo, in vitro)

		ORAI1	TRPC6
Gene Name		ORAI calcium release-activated calcium modulator 1	transient receptor potential cation channel, subfamily C, member 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Membrane Protein Complex	Plasma Membrane Integral Component Of Membrane Slit Diaphragm
	Molecular Function	Protein Binding Calmodulin Binding Store-operated Calcium Channel Activity Identical Protein Binding	Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Store-operated Calcium Entry Immune System Process Blood Coagulation Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport	Cation Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Aging Blood Coagulation Platelet Activation Positive Regulation Of Ion Transmembrane Transporter Activity Ion Transmembrane Transport Positive Regulation Of Calcium Ion Transport Transmembrane Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Hypoxia
Pathways		Signaling by the B Cell Receptor (BCR) Platelet homeostasis Elevation of cytosolic Ca2+ levels Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Platelet calcium homeostasis Adaptive Immune System	G alpha (q) signalling events Signaling by GPCR Axon guidance TRP channels Effects of PIP2 hydrolysis Platelet calcium homeostasis G alpha (q) signalling events GPCR downstream signaling Ion channel transport Platelet homeostasis Role of second messengers in netrin-1 signaling Gastrin-CREB signalling pathway via PKC and MAPK Elevation of cytosolic Ca2+ levels Stimuli-sensing channels Platelet activation, signaling and aggregation Netrin-1 signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: TRPC3 TRPC6	9 interactors: FYN ITPR3 MX1 ORAI1 RNF24 SRC TRPC3 TRPC7 TRPM2
Entrez ID		84876	7225
HPRD ID		08599	04710
Ensembl ID			ENSG00000137672
Uniprot IDs		Q96D31	Q9Y210
PDB IDs		4EHQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Calcium Ion Transport Regulation Of Calcium Ion Transport Platelet Activation Positive Regulation Of Ion Transport Calcium Ion Transmembrane Transport Calcium Ion Transport Axon Guidance Blood Coagulation Hemostasis Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Response To Inorganic Substance Axonogenesis Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Regulation Of Ion Transport Neuron Projection Morphogenesis Cell Activation Response To Wounding Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Neuron Projection Development Metal Ion Transport Cell Projection Morphogenesis Cell Part Morphogenesis Positive Regulation Of Cardiac Muscle Hypertrophy Cation Transmembrane Transport Neuron Development Cell Morphogenesis Response To Abiotic Stimulus Response To ATP Neuron Differentiation Cell Projection Organization Regulation Of Cardiac Muscle Hypertrophy Cation Transport Locomotion Ion Transmembrane Transport Positive Regulation Of Calcium Ion Transport Into Cytosol Movement Of Cell Or Subcellular Component Positive Regulation Of Ion Transmembrane Transporter Activity Generation Of Neurons Positive Regulation Of Transporter Activity Cellular Response To Hydrogen Peroxide Neurogenesis Transmembrane Transport Ion Transport Cell Development	Calcium Ion Transport Blood Coagulation Hemostasis Platelet Activation Calcium Ion Transmembrane Transport Regulation Of Body Fluid Levels Wound Healing Response To Wounding Metal Ion Transport Response To Stress Cation Transport Cell Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ion Transport Manganese Ion Transmembrane Transport Cation Transmembrane Transport Axon Guidance Manganese Ion Transport Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Axonogenesis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axon Development Cell Morphogenesis Involved In Neuron Differentiation Ion Transmembrane Transport Response To Hydroperoxide Chemotaxis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neuron Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cell Morphogenesis Involved In Differentiation Phagocytosis Peptidyl-tyrosine Autophosphorylation Fc Receptor Signaling Pathway Innate Immune Response Neuron Projection Development Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Projection Morphogenesis Transmembrane Transport Cell Part Morphogenesis Transport Response To External Stimulus Neuron Development
Tagcloud ?		acinar agonist agonists carboxyl clustering coexpression depleted diminished dispersed glands hek intensities junctions mildly muscarinic nfat operated pm polybasic puncta recruits salivary soce stim1 stim1deltak stim2 stimulus store stores	blocker ca casr channels depending elicited eliminated exchanger expressions ip3 lymphocytes nicl2 nps plc rise sensing sepsis septic skf96365 sr stores tg thapsigargin transient trpc3 u73122 verapamil
Tagcloud (Difference) ?		acinar agonist agonists carboxyl clustering coexpression depleted diminished dispersed glands hek intensities junctions mildly muscarinic nfat operated pm polybasic puncta recruits salivary soce stim1 stim1deltak stim2 stimulus store	blocker ca casr channels depending elicited eliminated exchanger expressions ip3 lymphocytes nicl2 nps plc rise sensing sepsis septic skf96365 sr tg thapsigargin transient trpc3 u73122 verapamil
Tagcloud (Intersection) ?		stores