ORAI1 and TRPC6

Number of citations of the paper that reports this interaction (PubMedID 17360584)
58

Data Source:
HPRD (in vitro, in vivo)

		ORAI1	TRPC6
Description		ORAI calcium release-activated calcium modulator 1	transient receptor potential cation channel subfamily C member 6
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GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Calcium Channel Complex Plasma Membrane Raft Membrane Raft	Cytoplasm Plasma Membrane Membrane Cation Channel Complex Slit Diaphragm
	Molecular Function	Calcium Channel Activity Protein Binding Calmodulin Binding Store-operated Calcium Channel Activity Identical Protein Binding	Actin Binding Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Protein Homodimerization Activity Actinin Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Store-operated Calcium Entry Adaptive Immune Response Immune System Process Monoatomic Ion Transport Calcium Ion Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Insulin Secretion Calcineurin-NFAT Signaling Cascade Monoatomic Ion Transmembrane Transport Positive Regulation Of Adenylate Cyclase Activity Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Mammary Gland Epithelium Development Calcium Ion Import Calcium Ion Transmembrane Transport Ligand-gated Ion Channel Signaling Pathway	Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Single Fertilization Neuron Differentiation Positive Regulation Of Ion Transmembrane Transporter Activity Monoatomic Ion Transmembrane Transport Positive Regulation Of Neuron Differentiation Negative Regulation Of Dendrite Morphogenesis Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transport Transmembrane Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Hypoxia
Pathways		Elevation of cytosolic Ca2+ levels Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases			Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Experiencing mood swings ( 29500382) Major depressive disorder ( 27777418)	Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) Daytime nap ( 33568662) DHEAS levels ( 34748635) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Lung adenocarcinoma ( 28604730) Menarche (age at onset) ( 25231870) Monocyte count ( 32888494) Plateletcrit ( 32888494) Severity of nausea and vomiting of pregnancy ( 29563502) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: TRPC3 TRPC6	9 interacting genes: FYN ITPR3 MX1 ORAI1 RNF24 SRC TRPC3 TRPC7 TRPM2
Entrez ID		84876	7225
HPRD ID		08599	04710
Ensembl ID		ENSG00000276045	ENSG00000137672
Uniprot IDs		Q96D31	Q9Y210
PDB IDs		2MAK 4EHQ	5YX9 6UZ8 6UZA 7A6U 7DXF 7DXG
Enriched GO Terms of Interacting Partners?		Inositol 1,4,5 Trisphosphate Binding Store-operated Calcium Channel Activity Cation Channel Complex Regulation Of Cytosolic Calcium Ion Concentration Calcium Channel Activity Single Fertilization Positive Regulation Of Calcium Ion Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Fertilization Positive Regulation Of Cytosolic Calcium Ion Concentration Monoatomic Ion Channel Activity Intracellular Calcium Ion Homeostasis Calcium Ion Transmembrane Transport Positive Regulation Of Monoatomic Ion Transport Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Calcium Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Metal Ion Transport Intracellular Monoatomic Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Inorganic Ion Homeostasis Regulation Of Monoatomic Ion Transport Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Chemical Homeostasis Slit Diaphragm Negative Regulation Of Dendrite Morphogenesis Metal Ion Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Calcium-activated Cation Channel Activity Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Cellular Homeostasis Positive Regulation Of Calcium Ion Transport Into Cytosol Inorganic Ion Transmembrane Transport Actinin Binding Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Positive Regulation Of Transport Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Chemical Homeostasis Monoatomic Ion Transport Response To ATP Monoatomic Cation Channel Activity Positive Regulation Of Ion Transmembrane Transporter Activity Clathrin Binding Positive Regulation Of Cardiac Muscle Hypertrophy Transmembrane Transport	Calcium Ion Transport Calcium Channel Activity Store-operated Calcium Channel Activity Calcium Ion Transmembrane Transport Inositol 1,4,5 Trisphosphate Binding Metal Ion Transport Monoatomic Cation Transport Monoatomic Ion Channel Activity Monoatomic Ion Transport Cellular Response To Hydrogen Peroxide Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Intracellularly Gated Calcium Channel Activity Inorganic Ion Transmembrane Transport Phospholipase Activator Activity Response To Hydrogen Peroxide Manganese Ion Transport Monoatomic Ion Transmembrane Transport Cellular Response To Reactive Oxygen Species Cation Channel Complex Response To Calcium Ion Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Response To Reactive Oxygen Species Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Calcium-mediated Signaling Ephrin Receptor Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Transmembrane Transport Membrane Raft Plasma Membrane Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Oxidative Stress Fc-gamma Receptor Signaling Pathway Calcium Ion Homeostasis Calcium Ion Import Regulation Of Calcium Ion Transport Leukocyte Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Homeostatic Process Membrane T Cell Costimulation Ephrin Receptor Signaling Pathway Cellular Response To Chemical Stress Perinuclear Region Of Cytoplasm Peptidyl-tyrosine Phosphorylation
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