CREB3L3 and PELI2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CREB3L3	PELI2
Gene Name		cAMP responsive element binding protein 3-like 3	pellino E3 ubiquitin protein ligase family member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cytosol
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding CAMP Response Element Binding	Protein Binding Ligase Activity
	Biological Process	Transcription, DNA-templated Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter	Positive Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll Signaling Pathway Protein Ubiquitination Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response
Pathways			Toll Like Receptor 7/8 (TLR7/8) Cascade Cytokine Signaling in Immune system Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Signaling by Interleukins Toll-Like Receptors Cascades MyD88 cascade initiated on plasma membrane Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor 4 (TLR4) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Interleukin-1 signaling Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation IRAK1 recruits IKK complex Innate Immune System
Drugs
Diseases
GWAS			Body mass index (interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Telomere length ( 21460395)
Protein-Protein Interactions		10 interactors: ATF6 BAD CEBPG CREB3 CREB3L1 KHDRBS1 KPNA2 PELI2 RIOK3 USP7	17 interactors: BCL10 CREB3L3 DEAF1 ERO1L FN1 FRYL HNRNPK IRAK1 IRAK2 IRAK4 LAMC3 LTBP3 MYD88 PICALM SRPK1 THAP7 UBQLN4
Entrez ID		84699	57161
HPRD ID		16752	17835
Ensembl ID		ENSG00000060566	ENSG00000139946
Uniprot IDs		B7ZL69 M0QYW7 Q68CJ9	Q9H716 Q9HAT8
PDB IDs			3EGA 3EGB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Positive Regulation Of Cellular Metabolic Process Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Viral Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Response To Stress Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Gene Expression Cellular Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Cellular Response To Chromate Response To Stimulus Cellular Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Intracellular Transport Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Mitochondrial Membrane Potential Positive Regulation Of RNA Export From Nucleus Release From Viral Latency Suppression By Virus Of Host Apoptotic Process Cellular Response To Stimulus Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Signal Transduction Positive Regulation Of Apoptotic Process By Virus Glucose Catabolic Process RNA Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Response To Organic Substance	Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway JNK Cascade Regulation Of Innate Immune Response Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Defense Response Positive Regulation Of NF-kappaB Transcription Factor Activity Cytokine Production Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Metabolic Process Innate Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response-regulating Signaling Pathway MAPK Cascade Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Response To Stress Response To Interleukin-1 Response To Peptidoglycan Regulation Of RNA Metabolic Process Signal Transduction By Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Smooth Muscle Cell Proliferation Immune System Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Molecule Of Bacterial Origin Interleukin-1-mediated Signaling Pathway Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Cytokine Biosynthetic Process Positive Regulation Of Peptidase Activity
Tagcloud ?		angpt2 antimetastatic atp6l cap2 ccr6 ccr7 cldn cortactin ddx3x gelatinolytic gli2 hccs hepg hk2 id1 kiaa0101 mechanistically microculture mortalin multitargeting pak1 prf prox1 rhoa silibinin sort spink1 stmn1 tetrazolium
Tagcloud (Difference) ?		angpt2 antimetastatic atp6l cap2 ccr6 ccr7 cldn cortactin ddx3x gelatinolytic gli2 hccs hepg hk2 id1 kiaa0101 mechanistically microculture mortalin multitargeting pak1 prf prox1 rhoa silibinin sort spink1 stmn1 tetrazolium
Tagcloud (Intersection) ?