CREB3L3 and ATF6

Number of citations of the paper that reports this interaction (PubMedID 16469704)
0

Data Source:
HPRD (in vivo)

		CREB3L3	ATF6
Description		cAMP responsive element binding protein 3 like 3	activating transcription factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Identical Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Positive Regulation Of Acute Inflammatory Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Positive Regulation Of Transcription By RNA Polymerase II	Eye Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Folding Response To Unfolded Protein Signal Transduction Visual Perception Positive Regulation Of Autophagy Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response ERAD Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of ATF6-mediated Unfolded Protein Response
Pathways		CREB3 factors activate genes Assembly of active LPL and LIPC lipase complexes	ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes Modulation of host responses by IFN-stimulated genes
Drugs			Pseudoephedrine
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Triglyceride levels ( 32203549)	Chronic bronchitis in chronic obstructive pulmonary disease ( 25241909) Parkinson's disease (age of onset) ( 19772629) Severe insulin-deficient type 2 diabetes ( 34737425) Systemic sclerosis ( 30247649)
Interacting Genes		30 interacting genes: ATF6 BAD CEBPG CEP19 CREB3 CREB3L1 CSNK2A1 CYB561A3 DPY30 FATE1 GPR25 GSK3B KHDRBS1 KPNA2 MCRS1 MS4A13 PELI2 RHAG RIOK3 RUSF1 SGTA SGTB SLC38A7 SLC39A9 STX5 TCEANC TMEM239 TRAF3IP3 USP7 YIPF6	18 interacting genes: APP ATF6B BPGM CREB1 CREB3L3 DAPK1 DDC GTF2I MAGI1 NFYA NFYC NNMT RNF168 SRF TNFRSF1A UBASH3A XBP1 YY1
Entrez ID		84699	22926
HPRD ID		16752	16118
Ensembl ID		ENSG00000060566	ENSG00000118217
Uniprot IDs		Q68CJ9	A0A7P0TAF2 A0A7P0Z421 A8K383 P18850
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Stress Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process TRC Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Autophagy Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Catabolic Process Response To Endoplasmic Reticulum Stress Negative Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Proteolysis Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Regulation Of Autophagy Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Unfolded Protein Positive Regulation Of Type I Interferon Production Regulation Of Apoptotic Signaling Pathway Identical Protein Binding Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Poly(U) RNA Binding Protein Binding Negative Regulation Of Apoptotic Signaling Pathway Golgi Membrane Membrane Protein Targeting To ER Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Regulation Of Macromolecule Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of DNA Metabolic Process RNA Polymerase II Transcription Regulator Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ER-nucleus Signaling Pathway Regulation Of Microtubule Anchoring At Centrosome Regulation Of Type I Interferon Production Golgi Apparatus Methylammonium Transmembrane Transporter Activity	Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Transcription Cis-regulatory Region Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process CCAAT-binding Factor Complex DNA Binding Regulation Of Gene Expression Protein-DNA Complex Response To Cytokine Regulation Of Macromolecule Biosynthetic Process Response To Peptide Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process ATF6-mediated Unfolded Protein Response Hemopoiesis Regulation Of Metabolic Process Myeloid Cell Development Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of MiRNA Transcription Response To Stress Nucleobase-containing Compound Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Stress Nucleoplasm Response To Unfolded Protein Regulation Of MiRNA Metabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Associative Learning Regulation Of Cellular Response To Stress
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