CREB3L3 and DPY30

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CREB3L3	DPY30
Description		cAMP responsive element binding protein 3 like 3	dpy-30 histone methyltransferase complex regulatory subunit
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane	Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex MLL1/2 Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of Acute Inflammatory Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Positive Regulation Of Transcription By RNA Polymerase II	Chromatin Organization Endosomal Transport Transcription Initiation-coupled Chromatin Remodeling
Pathways		CREB3 factors activate genes Assembly of active LPL and LIPC lipase complexes	PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Triglyceride levels ( 32203549)	Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)
Interacting Genes		30 interacting genes: ATF6 BAD CEBPG CEP19 CREB3 CREB3L1 CSNK2A1 CYB561A3 DPY30 FATE1 GPR25 GSK3B KHDRBS1 KPNA2 MCRS1 MS4A13 PELI2 RHAG RIOK3 RUSF1 SGTA SGTB SLC38A7 SLC39A9 STX5 TCEANC TMEM239 TRAF3IP3 USP7 YIPF6	33 interacting genes: AK8 AKAP14 ARFGEF1 ASH2L BCAS4 BEND3 CDK17 CFAP91 CHMP2B CREB3L3 DYDC1 DYDC2 FAM136A GPATCH2 GTF2I H3-4 ICA1L KMT2C MRFAP1 OTX1 PRPF3 PRRC2B PSMC3 PSMD14 PXN RSPH3 SETD1A TMCC2 TSPY10 TSPY2 TSPY3 UBC ZFYVE19
Entrez ID		84699	84661
HPRD ID		16752	17434
Ensembl ID		ENSG00000060566	ENSG00000162961
Uniprot IDs		Q68CJ9	Q9C005
PDB IDs			3G36 4RIQ 4RT4 4RTA 6E2H 6PWV 7UD5
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Stress Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process TRC Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Autophagy Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Catabolic Process Response To Endoplasmic Reticulum Stress Negative Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Proteolysis Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Regulation Of Autophagy Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Unfolded Protein Positive Regulation Of Type I Interferon Production Regulation Of Apoptotic Signaling Pathway Identical Protein Binding Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Poly(U) RNA Binding Protein Binding Negative Regulation Of Apoptotic Signaling Pathway Golgi Membrane Membrane Protein Targeting To ER Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Regulation Of Macromolecule Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of DNA Metabolic Process RNA Polymerase II Transcription Regulator Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ER-nucleus Signaling Pathway Regulation Of Microtubule Anchoring At Centrosome Regulation Of Type I Interferon Production Golgi Apparatus Methylammonium Transmembrane Transporter Activity	Set1C/COMPASS Complex Gonadal Mesoderm Development Histone Methyltransferase Complex Chromatin Remodeling Nucleosome Assembly Nucleosome Organization Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Chromatin Organization Mesoderm Development Mesenchyme Development MLL3/4 Complex Histone H3K4 Methyltransferase Activity Proteasome Accessory Complex Protein-DNA Complex Assembly Midbody Abscission Beta-catenin Binding Protein Kinase A Regulatory Subunit Binding Mitotic Cytokinetic Process 9+2 Motile Cilium Axoneme
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