MYPN and ANKRD1

Number of citations of the paper that reports this interaction (PMID 11309420)
43

Data Source:
BioGRID (pull down)
HPRD (two hybrid)

		MYPN	ANKRD1
Gene Name		myopalladin	ankyrin repeat domain 1 (cardiac muscle)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Z Disc I Band	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Cytosol Sarcomere I Band
	Molecular Function	Actin Binding Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Muscle Alpha-actinin Binding	RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity P53 Binding DNA Binding Transcription Corepressor Activity Protein Binding Titin Binding Histone Deacetylase Binding R-SMAD Binding
	Biological Process	Sarcomere Organization	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neuron Projection Development Cellular Response To Drug Skeletal Muscle Cell Differentiation Response To Muscle Stretch Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Lipid Metabolic Process Small Molecule Metabolic Process Sarcomere Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Secretion Cardiac Muscle Tissue Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of DNA Biosynthetic Process
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Optic disc size (disc) ( 20395239)
Protein-Protein Interactions		7 interactors: ACTN2 ACTN3 ANKRD1 ANKRD23 NEB NEBL TTN	5 interactors: CASQ2 MYPN TRIM55 TRIM63 TTN
Entrez ID		84665	27063
HPRD ID		10536	10647
Ensembl ID		ENSG00000138347	ENSG00000148677
Uniprot IDs		Q86TC9	Q15327
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Actin Filament-based Process Muscle Contraction Muscle System Process Myofibril Assembly Response To Muscle Stretch Actomyosin Structure Organization Muscle Structure Development Striated Muscle Cell Development Muscle Cell Development Cardiac Muscle Tissue Development Cardiac Myofibril Assembly Response To Mechanical Stimulus Striated Muscle Cell Differentiation Focal Adhesion Assembly Muscle Organ Development Cellular Component Assembly Striated Muscle Tissue Development Adherens Junction Assembly Muscle Cell Differentiation Muscle Tissue Development Cell-substrate Junction Assembly Sarcomere Organization Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Muscle Organ Morphogenesis Platelet Degranulation Organelle Assembly Adherens Junction Organization Cardiac Muscle Thin Filament Assembly Heart Development Cardiac Muscle Cell Differentiation Movement Of Cell Or Subcellular Component Actin Cytoskeleton Organization Cardiocyte Differentiation Sarcomerogenesis Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Cell-matrix Adhesion Directional Locomotion Platelet Activation Myosin Filament Assembly Cell Junction Assembly Cardiovascular System Development Cell-cell Junction Organization Cell-substrate Adhesion	Sarcomere Organization Myofibril Assembly Actomyosin Structure Organization Striated Muscle Cell Development Muscle Cell Development Muscle Contraction Striated Muscle Cell Differentiation Muscle System Process Muscle Cell Differentiation Cardiac Muscle Contraction Heart Contraction Organelle Assembly Muscle Structure Development Striated Muscle Contraction Actin Cytoskeleton Organization Actin Filament-based Process Response To Calcium Ion Sarcomerogenesis Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Directional Locomotion Sequestering Of Calcium Ion Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Anatomical Structure Formation Involved In Morphogenesis Myosin Filament Assembly Cytoskeleton Organization Skeletal Muscle Atrophy Skeletal Muscle Thin Filament Assembly Striated Muscle Atrophy Muscle Atrophy Blood Circulation Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Response To Metal Ion Skeletal Muscle Adaptation Cellular Protein Complex Assembly Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sequestering Of Metal Ion Cellular Response To Caffeine Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Cellular Response To Organic Cyclic Compound Negative Regulation Of Potassium Ion Transmembrane Transport Cell-cell Signaling Involved In Cardiac Conduction Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Adult Heart Development
Tagcloud ?			adenovirus ang angiotensin ankyrin antagonized attempted cardiomyocyte cardiomyocytes carp constriction exacerbated exacerbates failing fractional hearts inconclusive infarction modulates myocardial nrcs overload permeability repeat shortening tac termed transverse upregulate upregulation
Tagcloud (Difference) ?			adenovirus ang angiotensin ankyrin antagonized attempted cardiomyocyte cardiomyocytes carp constriction exacerbated exacerbates failing fractional hearts inconclusive infarction modulates myocardial nrcs overload permeability repeat shortening tac termed transverse upregulate upregulation
Tagcloud (Intersection) ?