MYPN and PDLIM3

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		MYPN	PDLIM3
Description		myopalladin	PDZ and LIM domain 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Sarcomere Z Disc Axon I Band	Stress Fiber Cytoplasm Cytosol Adherens Junction Actin Cytoskeleton Z Disc Filamentous Actin
	Molecular Function	Actin Binding Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Muscle Alpha-actinin Binding Cell-cell Adhesion Mediator Activity	Actin Binding Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Metal Ion Binding Muscle Alpha-actinin Binding
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Sarcomere Organization Dendrite Self-avoidance	Actin Filament Organization Heart Development Actin Cytoskeleton Organization Muscle Structure Development
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Atrial fibrillation ( 30061737) Chronic kidney disease ( 31152163) Coffee consumption ( 31046077) Creatine kinase levels ( 29403010) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766 31451708 31152163 31015462) Estimated glomerular filtration rate in non-diabetics ( 31451708) FEV1 ( 30804560) Glomerular filtration rate ( 29403010) Height ( 25282103) Hip circumference adjusted for BMI ( 34021172) Lung function (FVC) ( 30804560 28166213) Optic nerve measurement (disc area) ( 20395239) Peak expiratory flow ( 30804560) Psoriasis ( 25854761)
Interacting Genes		8 interacting genes: ACTN2 ACTN3 ANKRD1 ANKRD23 NEB NEBL PDLIM3 TTN	11 interacting genes: ABCA1 ACTN2 FHL1 MYOT MYOZ2 MYOZ3 MYPN PALLD RANBP2 RHOU RYR1
Entrez ID		84665	27295
HPRD ID		10536	08388
Ensembl ID		ENSG00000138347	ENSG00000154553
Uniprot IDs		A0A087WX60 Q86TC9	A0A087WYF8 A0A2U3TZH4 Q53GG5
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Muscle Z Disc I Band Actin Cytoskeleton Actin Filament Binding Cytoskeletal Protein Binding Titin Binding Response To Muscle Stretch Actin Cytoskeleton Organization Actin Binding Actin Filament-based Process Cardiac Muscle Thin Filament Assembly Sarcomere Organization Myofibril Sarcomere Actin Filament Organization Muscle Cell Development Actomyosin Structure Organization Muscle Alpha-actinin Binding Pseudopodium Cytoskeleton Organization Supramolecular Fiber Organization Focal Adhesion Assembly Response To Mechanical Stimulus Cell-substrate Junction Assembly Cardiac Muscle Cell Development Cell-substrate Junction Organization Cardiac Cell Development Cortical Actin Cytoskeleton Cardiac Muscle Tissue Morphogenesis Regulation Of Actin Cytoskeleton Organization Actin Filament Uncapping Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Striated Muscle Cell Development Muscle Tissue Morphogenesis Regulation Of Actin Filament-based Process Actin Filament Stress Fiber Titin Z Domain Binding Cytoplasm Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Sarcomerogenesis Extracellular Exosome Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Bone Mineralization Involved In Bone Maturation Skeletal Muscle Myosin Thick Filament Assembly Regulation Of Cytoskeleton Organization	Z Disc FATZ Binding Actin Binding Actin Cytoskeleton Actin Cytoskeleton Organization Sarcomere Organization Actin Filament-based Process Sarcomere Channel Activator Activity Telethonin Binding Muscle Alpha-actinin Binding Actomyosin Structure Organization Dendrite Self-avoidance Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules I Band Focal Adhesion Positive Regulation Of Potassium Ion Transport Cell-cell Adhesion Mediator Activity Sarcoplasmic Reticulum Membrane Structural Constituent Of Muscle Cytoskeleton Organization Axon Guidance Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Neuron Projection Guidance Podosome Neuron Recognition Organelle Organization Sphingolipid Floppase Activity Actin Filament Uncapping Regulation Of Intracellular Transport Cytoskeletal Protein Binding Sarcoplasmic Reticulum Striated Muscle Cell Development Response To Vitamin B3 Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity Titin Z Domain Binding Cytoplasmic Periphery Of The Nuclear Pore Complex Ryanodine Receptor Complex Regulation Of Potassium Ion Transport Actin Filament Regulation Of High-density Lipoprotein Particle Assembly Muscle Cell Development Phospholipase C-activating Angiotensin-activated Signaling Pathway Ryanodine-sensitive Calcium-release Channel Activity Skeletal Muscle Fiber Adaptation Cell Adhesion Plasma Membrane Bounded Cell Projection Organization Axon Phosphatidylserine Floppase Activity
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