MYPN and TTN

Number of citations of the paper that reports this interaction (PMID 14583192)
60

Data Source:
BioGRID (two hybrid)

		MYPN	TTN
Gene Name		myopalladin	titin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Z Disc I Band	Condensed Nuclear Chromosome Extracellular Region Cytosol Striated Muscle Thin Filament Z Disc M Band I Band Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Muscle Alpha-actinin Binding	Protease Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Enzyme Binding Protein Kinase Binding Telethonin Binding Identical Protein Binding Actinin Binding Protein Self-association Actin Filament Binding Muscle Alpha-actinin Binding Structural Molecule Activity Conferring Elasticity
	Biological Process	Sarcomere Organization	Platelet Degranulation Cardiac Muscle Hypertrophy Muscle Contraction Striated Muscle Contraction Mitotic Chromosome Condensation Blood Coagulation Peptidyl-tyrosine Phosphorylation Muscle Filament Sliding Platelet Activation Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Detection Of Muscle Stretch Sarcomere Organization Regulation Of Protein Kinase Activity Cardiac Muscle Fiber Development Sarcomerogenesis Regulation Of Catalytic Activity Response To Calcium Ion Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways			Striated Muscle Contraction Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Optic disc size (disc) ( 20395239)	Breast size ( 22747683) QT interval ( 20031603)
Protein-Protein Interactions		7 interactors: ACTN2 ACTN3 ANKRD1 ANKRD23 NEB NEBL TTN	29 interactors: ACTA1 ACTN1 ACTN2 ANK1 ANKRD1 ANKRD2 ANKRD23 CALM1 CAPN3 CRYAB FHL1 FHL2 FLNA MAPK1 MYBPC1 MYBPC3 MYH9 MYOM1 MYOM2 MYPN NBR1 NEB OBSCN SQSTM1 SRPK2 TCAP TRIM55 TRIM63 VAV2
Entrez ID		84665	7273
HPRD ID		10536	01787
Ensembl ID		ENSG00000138347	ENSG00000155657
Uniprot IDs		Q86TC9	Q7Z3B7 Q8WZ42
PDB IDs			1BPV 1G1C 1NCT 1NCU 1TIT 1TIU 1TKI 1TNM 1TNN 1WAA 1YA5 2A38 2BK8 2F8V 2ILL 2J8H 2J8O 2NZI 2RQ8 2WP3 2WWK 2WWM 2Y9R 3B43 3KNB 3LCY 3LPW 3PUC 3Q5O 3QP3
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Actin Filament-based Process Muscle Contraction Muscle System Process Myofibril Assembly Response To Muscle Stretch Actomyosin Structure Organization Muscle Structure Development Striated Muscle Cell Development Muscle Cell Development Cardiac Muscle Tissue Development Cardiac Myofibril Assembly Response To Mechanical Stimulus Striated Muscle Cell Differentiation Focal Adhesion Assembly Muscle Organ Development Cellular Component Assembly Striated Muscle Tissue Development Adherens Junction Assembly Muscle Cell Differentiation Muscle Tissue Development Cell-substrate Junction Assembly Sarcomere Organization Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Muscle Organ Morphogenesis Platelet Degranulation Organelle Assembly Adherens Junction Organization Cardiac Muscle Thin Filament Assembly Heart Development Cardiac Muscle Cell Differentiation Movement Of Cell Or Subcellular Component Actin Cytoskeleton Organization Cardiocyte Differentiation Sarcomerogenesis Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Cell-matrix Adhesion Directional Locomotion Platelet Activation Myosin Filament Assembly Cell Junction Assembly Cardiovascular System Development Cell-cell Junction Organization Cell-substrate Adhesion	Muscle Contraction Muscle System Process Muscle Structure Development Actin Filament-based Process Actomyosin Structure Organization Actin Filament-based Movement Actin-myosin Filament Sliding Muscle Filament Sliding Myofibril Assembly Striated Muscle Cell Differentiation Striated Muscle Cell Development Actin-mediated Cell Contraction Muscle Cell Development Sarcomere Organization Muscle Organ Development Muscle Cell Differentiation Cellular Component Assembly Actin Cytoskeleton Organization Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Morphogenesis Cytoskeleton Organization Platelet Activation Cell Differentiation Cell Development Organelle Assembly Developmental Process Anatomical Structure Development Organ Development Blood Coagulation Hemostasis System Development Multicellular Organismal Development Platelet Degranulation Striated Muscle Tissue Development Response To Stress Muscle Tissue Development Response To Abiotic Stimulus Regulation Of Apoptotic Process Response To External Stimulus Regulation Of Body Fluid Levels Organelle Organization Neurotrophin TRK Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Response To Stimulus Wound Healing Cardiovascular System Development Neurotrophin Signaling Pathway Regulation Of Cell Death Regulation Of Intracellular Transport Cell Activation
Tagcloud ?			amounts anticancer atlas braf broad diverse exome frequencies frequency frg1b harbored includes integrated lineage metastastic muc16 mutated mutational obtain omics pbrm1 resource sequencing somatic subtypes summarized ush2a varied vhl
Tagcloud (Difference) ?			amounts anticancer atlas braf broad diverse exome frequencies frequency frg1b harbored includes integrated lineage metastastic muc16 mutated mutational obtain omics pbrm1 resource sequencing somatic subtypes summarized ush2a varied vhl
Tagcloud (Intersection) ?