RIC1

Description		RIC1 partner of RAB6A GEF complex
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Membrane Trans-Golgi Network Membrane Protein-containing Complex Ric1-Rgp1 Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding
	Biological Process	Regulation Of Extracellular Matrix Constituent Secretion Intracellular Protein Transport Retrograde Transport, Endosome To Golgi Negative Regulation Of Protein Catabolic Process Positive Regulation Of GTPase Activity Cranial Skeletal System Development
Pathways		Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Serum alkaline phosphatase levels ( 33339817 33547301)
Interacting Genes		2 interacting genes: MAP1LC3A MAP1LC3B
Entrez ID		57589
HPRD ID		13858
Ensembl ID		ENSG00000107036
Uniprot IDs		Q4ADV7
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagosome Maturation Organelle Membrane Autophagosome Membrane Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Autophagosome Organization Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Cellular Response To Starvation Response To Starvation Microtubule Binding Cellular Response To Nutrient Levels Endomembrane System Autophagy Ubiquitin Protein Ligase Binding Microtubule Cellular Response To Oxygen-glucose Deprivation Response To Nutrient Levels Response To Iron(II) Ion Ceramide Binding Response To Oxygen-glucose Deprivation Autolysosome Organelle Assembly Response To Lead Ion Cytoplasmic Vesicle Cellular Response To Copper Ion SMAD Protein Signal Transduction P38MAPK Cascade Response To Iron Ion Response To Copper Ion Protein-containing Complex Organization Cytoskeleton Cellular Response To Amino Acid Starvation JNK Cascade Response To Amino Acid Starvation Cellular Response To Hydrogen Peroxide Cellular Response To Stress Response To Hydrogen Peroxide Catabolic Process Cellular Response To Reactive Oxygen Species Axoneme Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Late Endosome
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