ANK3 and KCNC1

Number of citations of the paper that reports this interaction (PubMedID 12805291)
59

Data Source:
HPRD (in vivo)

		ANK3	KCNC1
Description		ankyrin 3	potassium voltage-gated channel subfamily C member 1
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Basal Plasma Membrane Cell Surface Intercalated Disc Spectrin-associated Cytoskeleton Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Sarcoplasmic Reticulum Z Disc T-tubule Axon Dendrite Neuromuscular Junction Node Of Ranvier Sarcolemma Cell Projection Neuron Projection Costamere Axon Initial Segment Organelle Synapse Postsynaptic Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Axon Dendrite Axolemma Neuron Projection Membrane Dendrite Membrane Neuronal Cell Body Membrane Monoatomic Ion Channel Complex Presynaptic Membrane Cell Projection Neuronal Cell Body Axon Terminus Calyx Of Held Synapse Postsynaptic Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Cytoskeletal Anchor Activity Sodium Channel Regulator Activity Spectrin Binding Protein-macromolecule Adaptor Activity Transmembrane Transporter Binding Cadherin Binding Channel Activator Activity	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Kinesin Binding Gated Channel Activity Transmembrane Transporter Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
	Biological Process	Mitotic Cytokinesis Plasma Membrane Organization Cytoskeleton Organization Signal Transduction Axonogenesis Neuromuscular Junction Development Positive Regulation Of Gene Expression Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Sodium Ion Transport Magnesium Ion Homeostasis Neuronal Action Potential Positive Regulation Of Homotypic Cell-cell Adhesion Golgi To Plasma Membrane Protein Transport Regulation Of Potassium Ion Transport Establishment Of Protein Localization Positive Regulation Of Membrane Potential Golgi Vesicle Transport Cellular Response To Magnesium Ion Membrane Assembly Protein Localization To Plasma Membrane Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Protein Localization To Axon Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity	Action Potential Monoatomic Ion Transport Potassium Ion Transport Response To Toxic Substance Response To Light Intensity Response To Auditory Stimulus Response To Amine Cerebellum Development Optic Nerve Development Globus Pallidus Development Corpus Callosum Development Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Response To Potassium Ion Protein Homooligomerization Protein Tetramerization Transmembrane Transport Cellular Response To Xenobiotic Stimulus Response To Fibroblast Growth Factor Potassium Ion Transmembrane Transport Regulation Of Presynaptic Membrane Potential Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Response To Nerve Growth Factor
Pathways		Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins COPI-mediated anterograde transport Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	Voltage gated Potassium channels
Drugs			Enflurane Promethazine Miconazole Dalfampridine
Diseases
GWAS		Adventurousness ( 30643258) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 33097823) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Behavioral disturbance or psychiatric symptoms and prion disease ( 25897833) Bipolar disorder ( 18711365 33263727 31043756 34002096 28072414 24618891 22182935 21926972 20351715) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) ( 31372216) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Diastolic blood pressure ( 30224653) Frailty index ( 34431594) Heel bone mineral density ( 30598549) Height ( 31562340) Metabolite levels ( 23823483) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457) Psychotic experience ( 31553412) Refractive error ( 32231278) Schizophrenia ( 20185149) Third ventricle volume ( 31530798) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)	Body mass index ( 26426971) Night sleep phenotypes ( 27126917) Opioid sensitivity ( 24143882)
Interacting Genes		22 interacting genes: FADD FAS GABARAP HOOK1 KCNC1 MAP1LC3A MAP1LC3C MAPK6 NAB2 NEDD4 PIK3R1 PLEC RIPK4 RNF10 SCN1B SCN2A SCNN1B SMAD2 SMAD3 SPTBN4 SRPK2 YAP1	7 interacting genes: ANK3 KCNG3 KCNH1 KCNV2 LPAR3 TMBIM6 TRARG1
Entrez ID		288	3746
HPRD ID		02715	15936
Ensembl ID		ENSG00000151150	ENSG00000129159
Uniprot IDs		Q12955 Q8NAK2	P48547
PDB IDs		4O6X	7PHH 7PHI 7PHK 7PHL 7PQT 7PQU 8F1C 8F1D 8QUC 8QUD
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Nitrogen Starvation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Phosphatidylethanolamine Binding Node Of Ranvier Paraxial Mesoderm Morphogenesis SMAD Protein Signal Transduction Autophagosome Signal Transduction Response To Nutrient Levels Protein-containing Complex Organization Mesoderm Morphogenesis CD95 Death-inducing Signaling Complex Pericardium Development Death-inducing Signaling Complex SMAD Protein Complex Trophoblast Cell Migration Sodium Channel Complex Phospholipid Binding Cellular Response To Nutrient Levels Heteromeric SMAD Protein Complex Ameboidal-type Cell Migration Sodium Channel Inhibitor Activity Autophagosome Maturation Necroptotic Signaling Pathway Phosphatase Binding Autophagosome Membrane Negative Regulation Of Programmed Cell Death Cytosol Embryonic Foregut Morphogenesis Mitophagy Mesenchyme Development Regulation Of Programmed Cell Death Autolysosome Nodal Signaling Pathway Co-SMAD Binding Ubiquitin Protein Ligase Binding Positive Regulation Of Nucleocytoplasmic Transport Voltage-gated Sodium Channel Complex Primary MiRNA Processing Regulation Of Sodium Ion Transport Vacuole Organization Cellular Response To Starvation Motor Neuron Apoptotic Process Cellular Response To Mechanical Stimulus Regulation Of Biological Quality Transforming Growth Factor Beta Receptor Binding Wound Healing Sodium Ion Transport	Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Regulation Of Metal Ion Transport Action Potential Regulation Of Membrane Potential Regulation Of Monoatomic Ion Transport Monoatomic Ion Channel Complex Potassium Ion Transmembrane Transport Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Biological Quality Plasma Membrane Inorganic Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Potassium Channel Regulator Activity Regulation Of Monoatomic Ion Transmembrane Transport Establishment Of Protein Localization To Plasma Membrane Monoatomic Ion Transport Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Axon Negative Regulation Of Monoatomic Ion Transmembrane Transport Cyclic Nucleotide Binding Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Potassium Ion Transport Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Protein Location In Plasma Membrane Endoribonuclease Inhibitor Activity Negative Regulation Of Transmembrane Transport Positive Regulation Of Cell Communication By Electrical Coupling Vesicle-mediated Transport To The Plasma Membrane Membrane Lysophosphatidic Acid Receptor Activity Regulation Of Transport Cellular Response To Metal Ion Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Calcium Ion Transport Into Cytosol Cellular Response To Magnesium Ion Positive Regulation Of Monoatomic Ion Transport Negative Regulation Of IRE1-mediated Unfolded Protein Response Glucose Import In Response To Insulin Stimulus Protein Localization To Plasma Membrane
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