ANK3 and KCNC1

Number of citations of the paper that reports this interaction (PMID 12805291)
27

Data Source:
HPRD (in vivo)

		ANK3	KCNC1
Gene Name		ankyrin 3, node of Ranvier (ankyrin G)	potassium channel, voltage gated Shaw related subfamily C, member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Tight Junction Basal Plasma Membrane Cell Surface Intercalated Disc Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Lateral Plasma Membrane Sarcoplasmic Reticulum Z Disc T-tubule Dendrite Neuromuscular Junction Node Of Ranvier Paranode Region Of Axon Sarcolemma Costamere Axon Initial Segment Postsynaptic Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Axolemma Dendrite Membrane Neuronal Cell Body Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Spectrin Binding Protein Binding, Bridging Ion Channel Binding Cadherin Binding	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Kinesin Binding
	Biological Process	Mitotic Cytokinesis Plasma Membrane Organization Cytoskeletal Anchoring At Plasma Membrane Signal Transduction Axonogenesis Axon Guidance Neuromuscular Junction Development Positive Regulation Of Gene Expression Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Sodium Ion Transport Magnesium Ion Homeostasis Neuronal Action Potential Positive Regulation Of Homotypic Cell-cell Adhesion Golgi To Plasma Membrane Protein Transport Regulation Of Potassium Ion Transport Establishment Of Protein Localization Positive Regulation Of Membrane Potential Cellular Response To Magnesium Ion Membrane Assembly Protein Localization To Plasma Membrane Maintenance Of Protein Location In Plasma Membrane Protein Targeting To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	Potassium Ion Transport Synaptic Transmission Regulation Of Ion Transmembrane Transport Protein Homooligomerization Potassium Ion Transmembrane Transport
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions	Potassium Channels Voltage gated Potassium channels
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 22182935 21926972 18711365) Bipolar disorder and major depressive disorder (combined) ( 20351715) Schizophrenia ( 20185149)
Protein-Protein Interactions		12 interactors: FADD FAS HOOK1 KCNC1 MAPK6 PIK3R1 SCN1B SCN2A SCNN1B SMAD2 SMAD3 SPTBN4	4 interactors: ANK3 KCNG3 KCNH1 KCNV2
Entrez ID		288	3746
HPRD ID		02715	15936
Ensembl ID		ENSG00000151150	ENSG00000129159
Uniprot IDs		Q12955 Q8NAK2	K4DI87 P48547 Q3KNS8
PDB IDs
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Neuron Apoptotic Process Transmission Of Nerve Impulse Necroptotic Signaling Pathway Primary MiRNA Processing Neuron Death SMAD Protein Complex Assembly Paraxial Mesoderm Morphogenesis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Communication Nodal Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Embryonic Foregut Morphogenesis Positive Regulation Of Endopeptidase Activity Lymphocyte Activation Foregut Morphogenesis Paraxial Mesoderm Development Positive Regulation Of Peptidase Activity Cell Differentiation Regulation Of Cell Differentiation Production Of MiRNAs Involved In Gene Silencing By MiRNA Multicellular Organismal Development Pericardium Development Apoptotic Process Leukocyte Activation Anatomical Structure Development Programmed Cell Death Regulation Of Myeloid Cell Differentiation Signal Transduction Involved In Regulation Of Gene Expression Transport Protein Complex Assembly Cell Death Death Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Necroptotic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Abiotic Stimulus Sodium Ion Transmembrane Transport Regulation Of Cysteine-type Endopeptidase Activity Gene Silencing By MiRNA Membrane Depolarization During Action Potential	Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Potassium Ion Transmembrane Transport Potassium Ion Transport Synaptic Transmission Monovalent Inorganic Cation Transport Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Metal Ion Transport Cell-cell Signaling Cation Transmembrane Transport Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Cell Communication By Electrical Coupling Cation Transport Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Cellular Response To Magnesium Ion Ion Transmembrane Transport Protein Homooligomerization Regulation Of Membrane Potential Regulation Of Membrane Depolarization During Action Potential Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Action Potential Transmembrane Transport Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Peptidyl-histidine Phosphorylation Regulation Of Cell Communication By Electrical Coupling Cytoskeletal Anchoring At Plasma Membrane Protein Oligomerization Cellular Component Assembly Transport Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Phosphorelay Signal Transduction System Positive Regulation Of Sodium Ion Transmembrane Transport Magnesium Ion Homeostasis Response To Magnesium Ion Signaling Negative Regulation Of Cation Channel Activity Cell Communication Myoblast Fusion Negative Regulation Of Potassium Ion Transport Membrane Assembly Golgi To Plasma Membrane Protein Transport Membrane Biogenesis Neuronal Action Potential Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Protein Targeting To Membrane
Tagcloud ?		add adipocytes algorithms backward bd bipolar categorical chi2 contingency doi escitalopram expand lithium meaningful mp ordinal pkc psychiatry publication remove rs10761482 snp stepwise suffer swedish switches tables takes variance
Tagcloud (Difference) ?		add adipocytes algorithms backward bd bipolar categorical chi2 contingency doi escitalopram expand lithium meaningful mp ordinal pkc psychiatry publication remove rs10761482 snp stepwise suffer swedish switches tables takes variance
Tagcloud (Intersection) ?