DHX16 and MEGF10

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		DHX16	MEGF10
Description		DEAH-box helicase 16	multiple EGF like domains 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm U2-type Precatalytic Spliceosome Ribonucleoprotein Complex	Phagocytic Cup Plasma Membrane Membrane Cell Projection
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity Pattern Recognition Receptor Activity Ubiquitin Binding Molecular Adaptor Activity	Complement Component C1q Complex Binding Scavenger Receptor Activity Notch Binding
	Biological Process	MRNA Splicing, Via Spliceosome Immune System Process MRNA Processing RNA Splicing Innate Immune Response Antiviral Innate Immune Response	Phagocytosis Cell Adhesion Muscle Organ Development Skeletal Muscle Satellite Cell Activation Skeletal Muscle Satellite Cell Differentiation Skeletal Muscle Satellite Cell Proliferation Vesicle-mediated Transport Positive Regulation Of Cell-cell Adhesion Muscle Cell Proliferation Homotypic Cell-cell Adhesion Apoptotic Cell Clearance Engulfment Of Apoptotic Cell Recognition Of Apoptotic Cell Cell Development Myoblast Development Regulation Of Skeletal Muscle Tissue Development Regulation Of Muscle Cell Differentiation Myoblast Migration Muscle Cell Development Apoptotic Process Involved In Development Positive Regulation Of Myoblast Proliferation
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alzheimer's disease (cognitive decline) ( 23535033) Appendicular lean mass ( 33097823) Bone mineral content ( 31790847) Chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) Hearing loss in Charcot-Marie-Tooth disease 1A ( 30958311) Initial pursuit acceleration ( 29064472) Response to antipsychotic treatment in schizophrenia ( 29503163)
Interacting Genes		13 interacting genes: APP APPBP2 COIL CSNK2A1 ESS2 HOMEZ MEGF10 MYO19 RIGI RNF10 SNRNP27 TFIP11 XAB2	24 interacting genes: AARS2 ALMS1 AP2M1 ARHGAP32 BAHD1 CADPS2 CEP57 CUL7 DHX16 GRB10 GULP1 HDAC4 ITSN2 MCF2L2 RANBP10 SART3 SCAPER SHANK3 SHTN1 SNRNP200 TAOK2 TMEM132A VWA8 ZNFX1
Entrez ID		8449	84466
HPRD ID		04555	14384
Ensembl ID		ENSG00000204560	ENSG00000145794
Uniprot IDs		A0A1U9X7L7 B4DZ28 O60231 Q5SQH4 Q5SQH5	Q96KG7
PDB IDs		5Z56 5Z57 5Z58 6FF7 7DVQ 7QTT 8CH6 8I0R 8I0S 8I0T 8I0U 8I0V
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing, Via Transesterification Reactions Catalytic Step 2 Spliceosome RNA Splicing MRNA Processing RNA Metabolic Process Negative Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Mitochondrion Migration Along Actin Filament	Cytoplasm
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