SYVN1 and VCP

Number of citations of the paper that reports this interaction (PMID 24100225)
1

Data Source:
BioGRID (pull down, x-ray crystallography, unspecified method)

		SYVN1	VCP
Gene Name		synovial apoptosis inhibitor 1, synoviolin	valosin containing protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Proteasome Complex Hrd1p Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Particle Cytosol Site Of Double-strand Break Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Ubiquitin Protein Ligase Activity	Receptor Binding Protein Binding ATP Binding Lipid Binding ATPase Activity Protein Phosphatase Binding Protein Domain Specific Binding Polyubiquitin Binding Protein Complex Binding Deubiquitinase Activator Activity Identical Protein Binding ADP Binding Poly(A) RNA Binding Ubiquitin-specific Protease Binding
	Biological Process	In Utero Embryonic Development Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	DNA Repair Double-strand Break Repair ER To Golgi Vesicle-mediated Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine Translesion Synthesis ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Hexamerization Cellular Response To Heat Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Protein Homooligomerization Aggresome Assembly Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Lys63-specific Deubiquitinase Activity
Pathways		Hedgehog ligand biogenesis IRE1alpha activates chaperones Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)	HSF1 activation Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog Cellular response to heat stress
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: AMFR APP ATN1 ATP6AP1 CLU ERN1 GPR37 TP53 UBE2D2 UBE2D3 UBE2J1 UBE2U UBE2Z USP7 VCP	72 interactors: AMFR AR ASPSCR1 ATG5 ATXN1 ATXN3 ATXN7 BRCA1 BRSK2 CAV1 CEP19 CRMP1 DERL1 DGCR6 DTNB FAM104A GZMK HDAC6 HERPUD1 HTT INSIG1 INSIG2 JAK2 LNX1 MAPK8IP2 NDRG1 NF1 NFKBIA NGLY1 NPLOC4 NSFL1C NUB1 OTULIN PLAA PRKCD PSMA1 PSMA7 PSMC1 PTPN3 RNF19A RNF31 RNF8 RPL9 RPS6KA1 SH2D2A SIK2 STUB1 STX5 SUMO4 SVIP SYVN1 TOM1L1 TOMM34 UBE4A UBE4B UBOX5 UBQLN1 UBXN1 UBXN2A UBXN2B UBXN6 UFD1L VCPIP1 VCPKMT VIMP WAC WBSCR22 WDYHV1 WRN YOD1 YWHAZ ZFAND2B
Entrez ID		84447	7415
HPRD ID		07618	03013
Ensembl ID		ENSG00000162298	ENSG00000165280
Uniprot IDs		Q86TM6	P55072 Q96IF9
PDB IDs			3EBB 3HU1 3HU2 3HU3 3QC8 3QQ7 3QQ8 3QWZ 3TIW
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Apoptotic Process Protein Modification By Small Protein Conjugation Protein Catabolic Process Programmed Cell Death Protein Polyubiquitination Cell Death Death Cellular Macromolecule Catabolic Process ER-nucleus Signaling Pathway Cellular Response To Stress ER-associated Ubiquitin-dependent Protein Catabolic Process Response To Endoplasmic Reticulum Stress Cellular Protein Modification Process Cellular Protein Metabolic Process Neuron Apoptotic Process Response To Stress Neuron Death Proteolysis DNA Repair Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Hypoxia Cellular Response To Unfolded Protein Cellular Response To Decreased Oxygen Levels Cellular Response To Stimulus Cellular Response To Oxygen Levels Cellular Response To Topologically Incorrect Protein Catabolic Process Protein Metabolic Process Cellular Metabolic Process Response To Unfolded Protein Regulation Of Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To DNA Damage Stimulus Positive Regulation Of Phosphorylation Regulation Of Protein Oligomerization Release Of Cytochrome C From Mitochondria Regulation Of Phosphorus Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Signal Transduction Protein K48-linked Ubiquitination Metabolic Process DNA Metabolic Process	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Protein Modification By Small Protein Conjugation Protein Ubiquitination Response To Stress Catabolic Process Protein Metabolic Process Protein Polyubiquitination Cellular Metabolic Process Regulation Of Protein Ubiquitination Cellular Protein Modification Process Cellular Response To Topologically Incorrect Protein ER-nucleus Signaling Pathway Golgi Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Communication Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stimulus Negative Regulation Of Apoptotic Process Regulation Of Proteolysis Negative Regulation Of Programmed Cell Death Regulation Of Cell Death Negative Regulation Of Cellular Protein Metabolic Process Apoptotic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Metabolic Process Negative Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Cellular Response To Unfolded Protein Programmed Cell Death Negative Regulation Of Protein Metabolic Process Cell Death Death Negative Regulation Of Signal Transduction Response To Stimulus Response To Unfolded Protein Negative Regulation Of Signaling
Tagcloud ?		array asd autism betulinic cortical div e16 e3 erad frontal gaba gabaa gabaaalpha1 gyrus lactacystin ligase lys48 mg132 middle neurobiological neurodevelopmental neuroplasticity pathophysiology polyubiquitination postmortem proteasomal proteasome qrt ups	17q11 3q28 9pter ap2 ap50 aps blots clapb1 clapm1 clathrin coated denoted designated dnas endocytosis lattice locations mapped maps oligonucleotide porcine primers probe q12 q34 rodent served stoichiometric triskelia
Tagcloud (Difference) ?		array asd autism betulinic cortical div e16 e3 erad frontal gaba gabaa gabaaalpha1 gyrus lactacystin ligase lys48 mg132 middle neurobiological neurodevelopmental neuroplasticity pathophysiology polyubiquitination postmortem proteasomal proteasome qrt ups	17q11 3q28 9pter ap2 ap50 aps blots clapb1 clapm1 clathrin coated denoted designated dnas endocytosis lattice locations mapped maps oligonucleotide porcine primers probe q12 q34 rodent served stoichiometric triskelia
Tagcloud (Intersection) ?