SYVN1 and UBE2J1

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		SYVN1	UBE2J1
Gene Name		synovial apoptosis inhibitor 1, synoviolin	ubiquitin-conjugating enzyme E2, J1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Ubiquitin Protein Ligase Activity	ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	In Utero Embryonic Development Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine ER-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		Hedgehog ligand biogenesis IRE1alpha activates chaperones Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: AMFR APP ATN1 ATP6AP1 CLU ERN1 GPR37 TP53 UBE2D2 UBE2D3 UBE2J1 UBE2U UBE2Z USP7 VCP	15 interactors: BIRC2 BRCA1 DIO2 LRSAM1 MAPKAPK2 PARK2 PJA2 RNF2 SOX6 SYVN1 TOPORS TP53 TRIM27 TRIM63 UBA1
Entrez ID		84447	51465
HPRD ID		07618	15599
Ensembl ID		ENSG00000162298	ENSG00000198833
Uniprot IDs		Q86TM6	Q9Y385
PDB IDs
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Apoptotic Process Protein Modification By Small Protein Conjugation Protein Catabolic Process Programmed Cell Death Protein Polyubiquitination Cell Death Death Cellular Macromolecule Catabolic Process ER-nucleus Signaling Pathway Cellular Response To Stress ER-associated Ubiquitin-dependent Protein Catabolic Process Response To Endoplasmic Reticulum Stress Cellular Protein Modification Process Cellular Protein Metabolic Process Neuron Apoptotic Process Response To Stress Neuron Death Proteolysis DNA Repair Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Hypoxia Cellular Response To Unfolded Protein Cellular Response To Decreased Oxygen Levels Cellular Response To Stimulus Cellular Response To Oxygen Levels Cellular Response To Topologically Incorrect Protein Catabolic Process Protein Metabolic Process Cellular Metabolic Process Response To Unfolded Protein Regulation Of Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To DNA Damage Stimulus Positive Regulation Of Phosphorylation Regulation Of Protein Oligomerization Release Of Cytochrome C From Mitochondria Regulation Of Phosphorus Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Signal Transduction Protein K48-linked Ubiquitination Metabolic Process DNA Metabolic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Protein Monoubiquitination Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Protein Autoubiquitination Cellular Metabolic Process Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Mitochondrion Degradation Protein K6-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Gene Expression Cellular Response To Stress Negative Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Signal Transduction By P53 Class Mediator Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Stress Gene Expression Cellular Response To Organic Substance Positive Regulation Of Organelle Organization Cellular Response To DNA Damage Stimulus DNA Damage Checkpoint Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		array asd autism betulinic cortical div e16 e3 erad frontal gaba gabaa gabaaalpha1 gyrus lactacystin ligase lys48 mg132 middle neurobiological neurodevelopmental neuroplasticity pathophysiology polyubiquitination postmortem proteasomal proteasome qrt ups	compromising conjugating cytosol destined dislocated dislocation e3 elongate elongating fail incomplete ligase lumen machinery participate proteasomal redundant resident seminiferous spermatids spermatogenesis spermiogenesis sterile thrive tubule ubiquitin ubiquitylated ultrastructural
Tagcloud (Difference) ?		array asd autism betulinic cortical div e16 erad frontal gaba gabaa gabaaalpha1 gyrus lactacystin lys48 mg132 middle neurobiological neurodevelopmental neuroplasticity pathophysiology polyubiquitination postmortem proteasome qrt ups	compromising conjugating cytosol destined dislocated dislocation elongate elongating fail incomplete lumen machinery participate redundant resident seminiferous spermatids spermatogenesis spermiogenesis sterile thrive tubule ubiquitin ubiquitylated ultrastructural
Tagcloud (Intersection) ?		e3 ligase proteasomal