SYVN1 and GPR37

Number of citations of the paper that reports this interaction (PMID 15572843)
0

Data Source:
BioGRID (enzymatic study)

		SYVN1	GPR37
Gene Name		synovial apoptosis inhibitor 1, synoviolin	G protein-coupled receptor 37 (endothelin receptor type B-like)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Ubiquitin Ligase Complex Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Ubiquitin Protein Ligase Activity	G-protein Coupled Receptor Activity Protein Binding G-protein Coupled Peptide Receptor Activity Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Peptide Binding
	Biological Process	In Utero Embryonic Development Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Locomotion Involved In Locomotory Behavior Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Pathways		Hedgehog ligand biogenesis IRE1alpha activates chaperones Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Reading and spelling ( 23738518)
Protein-Protein Interactions		15 interactors: AMFR APP ATN1 ATP6AP1 CLU ERN1 GPR37 TP53 UBE2D2 UBE2D3 UBE2J1 UBE2U UBE2Z USP7 VCP	8 interactors: ADRB2 GLP1R GRIP1 HSPA1A PARK2 SDCBP STUB1 SYVN1
Entrez ID		84447	2861
HPRD ID		07618	03992
Ensembl ID		ENSG00000162298
Uniprot IDs		Q86TM6	O15354
PDB IDs
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Apoptotic Process Protein Modification By Small Protein Conjugation Protein Catabolic Process Programmed Cell Death Protein Polyubiquitination Cell Death Death Cellular Macromolecule Catabolic Process ER-nucleus Signaling Pathway Cellular Response To Stress ER-associated Ubiquitin-dependent Protein Catabolic Process Response To Endoplasmic Reticulum Stress Cellular Protein Modification Process Cellular Protein Metabolic Process Neuron Apoptotic Process Response To Stress Neuron Death Proteolysis DNA Repair Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Hypoxia Cellular Response To Unfolded Protein Cellular Response To Decreased Oxygen Levels Cellular Response To Stimulus Cellular Response To Oxygen Levels Cellular Response To Topologically Incorrect Protein Catabolic Process Protein Metabolic Process Cellular Metabolic Process Response To Unfolded Protein Regulation Of Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To DNA Damage Stimulus Positive Regulation Of Phosphorylation Regulation Of Protein Oligomerization Release Of Cytochrome C From Mitochondria Regulation Of Phosphorus Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Signal Transduction Protein K48-linked Ubiquitination Metabolic Process DNA Metabolic Process	Response To Unfolded Protein Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Metabolic Process Cellular Response To Unfolded Protein Regulation Of Signaling Cellular Response To Topologically Incorrect Protein Positive Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Response To Endoplasmic Reticulum Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Stimulus Activation Of Adenylate Cyclase Activity Regulation Of Phosphorus Metabolic Process Protein K63-linked Ubiquitination Regulation Of Signal Transduction Positive Regulation Of Adenylate Cyclase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Signaling Pathway Proteasomal Protein Catabolic Process Regulation Of Binding Protein Autoubiquitination Regulation Of Metabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Lyase Activity Positive Regulation Of Protein Modification Process Negative Regulation Of Protein Binding Regulation Of Adenylate Cyclase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of CAMP Biosynthetic Process Response To Stress Response To Stimulus Regulation Of Cyclase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Communication Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Protein Stabilization Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity
Tagcloud ?		array asd autism betulinic cortical div e16 e3 erad frontal gaba gabaa gabaaalpha1 gyrus lactacystin ligase lys48 mg132 middle neurobiological neurodevelopmental neuroplasticity pathophysiology polyubiquitination postmortem proteasomal proteasome qrt ups	biosynthetic cd47 cycs dataset dj e2f6 eif2s1 eif2s2 encyclopedia extra fmr1 fxr2 logical mapt nrf1 paelr park2 park6 park7 parkin pen2 perturbation pink1 psenen retrieved seq stringent tomm34 unrecognized
Tagcloud (Difference) ?		array asd autism betulinic cortical div e16 e3 erad frontal gaba gabaa gabaaalpha1 gyrus lactacystin ligase lys48 mg132 middle neurobiological neurodevelopmental neuroplasticity pathophysiology polyubiquitination postmortem proteasomal proteasome qrt ups	biosynthetic cd47 cycs dataset dj e2f6 eif2s1 eif2s2 encyclopedia extra fmr1 fxr2 logical mapt nrf1 paelr park2 park6 park7 parkin pen2 perturbation pink1 psenen retrieved seq stringent tomm34 unrecognized
Tagcloud (Intersection) ?