VCP and UBXN1

Number of citations of the paper that reports this interaction (PMID 21135095)
4

Data Source:
BioGRID (two hybrid, pull down)

		VCP	UBXN1
Gene Name		valosin containing protein	UBX domain protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Proteasome Complex Hrd1p Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Particle Cytosol Site Of Double-strand Break Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Proteasome Complex Nucleus Cytoplasm Dendrite Cdc48p-Npl4p-Ufd1p AAA ATPase Complex Neuronal Cell Body
	Molecular Function	Receptor Binding Protein Binding ATP Binding Lipid Binding ATPase Activity Protein Phosphatase Binding Protein Domain Specific Binding Polyubiquitin Binding Protein Complex Binding Deubiquitinase Activator Activity Identical Protein Binding ADP Binding Poly(A) RNA Binding Ubiquitin-specific Protease Binding	Protein Binding Polyubiquitin Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding ATPase Binding K6-linked Polyubiquitin Binding
	Biological Process	DNA Repair Double-strand Break Repair ER To Golgi Vesicle-mediated Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine Translesion Synthesis ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Hexamerization Cellular Response To Heat Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Protein Homooligomerization Aggresome Assembly Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Lys63-specific Deubiquitinase Activity	Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		HSF1 activation Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog Cellular response to heat stress
Drugs
Diseases
GWAS
Protein-Protein Interactions		72 interactors: AMFR AR ASPSCR1 ATG5 ATXN1 ATXN3 ATXN7 BRCA1 BRSK2 CAV1 CEP19 CRMP1 DERL1 DGCR6 DTNB FAM104A GZMK HDAC6 HERPUD1 HTT INSIG1 INSIG2 JAK2 LNX1 MAPK8IP2 NDRG1 NF1 NFKBIA NGLY1 NPLOC4 NSFL1C NUB1 OTULIN PLAA PRKCD PSMA1 PSMA7 PSMC1 PTPN3 RNF19A RNF31 RNF8 RPL9 RPS6KA1 SH2D2A SIK2 STUB1 STX5 SUMO4 SVIP SYVN1 TOM1L1 TOMM34 UBE4A UBE4B UBOX5 UBQLN1 UBXN1 UBXN2A UBXN2B UBXN6 UFD1L VCPIP1 VCPKMT VIMP WAC WBSCR22 WDYHV1 WRN YOD1 YWHAZ ZFAND2B	15 interactors: ACVR1 BARD1 BMPR1B BRCA1 FAM189A2 HOMER2 PLA2G4A PLAA SMAD1 SMURF1 TGFBR1 TRIM39 UBE2I UBQLN1 VCP
Entrez ID		7415	51035
HPRD ID		03013	11266
Ensembl ID		ENSG00000165280	ENSG00000162191
Uniprot IDs		P55072 Q96IF9	Q04323
PDB IDs		3EBB 3HU1 3HU2 3HU3 3QC8 3QQ7 3QQ8 3QWZ 3TIW
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Protein Modification By Small Protein Conjugation Protein Ubiquitination Response To Stress Catabolic Process Protein Metabolic Process Protein Polyubiquitination Cellular Metabolic Process Regulation Of Protein Ubiquitination Cellular Protein Modification Process Cellular Response To Topologically Incorrect Protein ER-nucleus Signaling Pathway Golgi Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Communication Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stimulus Negative Regulation Of Apoptotic Process Regulation Of Proteolysis Negative Regulation Of Programmed Cell Death Regulation Of Cell Death Negative Regulation Of Cellular Protein Metabolic Process Apoptotic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Metabolic Process Negative Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Cellular Response To Unfolded Protein Programmed Cell Death Negative Regulation Of Protein Metabolic Process Cell Death Death Negative Regulation Of Signal Transduction Response To Stimulus Response To Unfolded Protein Negative Regulation Of Signaling	Regulation Of Apoptotic Process Regulation Of Cell Death BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Protein Modification Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Ossification Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Protein K6-linked Ubiquitination Regulation Of Signal Transduction Positive Regulation Of Osteoblast Differentiation Signal Transduction By Phosphorylation Regulation Of Cartilage Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Signaling Positive Regulation Of Cell Death Positive Regulation Of Ossification Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Stimulus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Protein Metabolic Process Pharyngeal System Development Regulation Of Osteoblast Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Postreplication Repair Inflammatory Response Activin Receptor Signaling Pathway Response To Organic Cyclic Compound Regulation Of Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Protein Polyubiquitination Negative Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Pattern Specification Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cartilage Development Positive Regulation Of Bone Mineralization Cell Cycle Process Positive Regulation Of Biomineral Tissue Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Tagcloud ?		17q11 3q28 9pter ap2 ap50 aps blots clapb1 clapm1 clathrin coated denoted designated dnas endocytosis lattice locations mapped maps oligonucleotide porcine primers probe q12 q34 rodent served stoichiometric triskelia	adaptor antiviral dengue disrupts exhibits innate interferes mavs nile oligomerization potently repressing rig rlr rlrs sendai sensed signalosome stomatitis stringently strongest tlr3 tlr4 traf3 traf6 underscore vesicular west
Tagcloud (Difference) ?		17q11 3q28 9pter ap2 ap50 aps blots clapb1 clapm1 clathrin coated denoted designated dnas endocytosis lattice locations mapped maps oligonucleotide porcine primers probe q12 q34 rodent served stoichiometric triskelia	adaptor antiviral dengue disrupts exhibits innate interferes mavs nile oligomerization potently repressing rig rlr rlrs sendai sensed signalosome stomatitis stringently strongest tlr3 tlr4 traf3 traf6 underscore vesicular west
Tagcloud (Intersection) ?