TBC1D7 and TRIM62

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBC1D7	TRIM62
Description		TBC1 domain family member 7	tripartite motif containing 62
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Cytoplasmic Vesicle TSC1-TSC2 Complex Ciliary Basal Body	Cytoplasm Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding TSC1-TSC2 Complex Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cellular Response To Starvation Positive Regulation Of Protein Ubiquitination Negative Regulation Of TOR Signaling Positive Regulation Of GTPase Activity Response To Growth Factor Activation Of GTPase Activity Negative Regulation Of Cilium Assembly Negative Regulation Of TORC1 Signaling	Immune System Process Negative Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Viral Release From Host Cell Negative Regulation Of Viral Transcription Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein K27-linked Ubiquitination Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Positive Regulation Of Antifungal Innate Immune Response
Pathways		TBC/RABGAPs	Interferon gamma signaling
Drugs
Diseases
GWAS		Migraine ( 23793025) Migraine without aura ( 23793025)	Gut microbiota (beta diversity) ( 27723756)
Interacting Genes		30 interacting genes: AKT1 ALOX5 APP BAG4 BLZF1 GABARAPL1 HOOK1 IKBKG INCA1 KEAP1 KRT19 KRT35 LDOC1 LNX2 LZTS1 LZTS2 MAP1LC3A MIPOL1 MMADHC NEDD4 NEDD4L PICK1 RPGRIP1 SH3GLB2 SSNA1 TRAF4 TRIM62 TSC1 XPA YWHAZ	19 interacting genes: CARD9 EAF1 EPN2 EXOSC5 FAIM GLRX PPP1R18 SKIL SMAD2 SP7 TBC1D7 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2L6 UBXN7 UTP25
Entrez ID		51256	55223
HPRD ID		18165	07697
Ensembl ID		ENSG00000145979	ENSG00000116525
Uniprot IDs		Q9P0N9 U3KPY5	Q9BVG3
PDB IDs		3QWL 4Z6Y 5EJC 5ULO 7DL2 9CE3
Enriched GO Terms of Interacting Partners?		Cytosol Cellular Response To Starvation Identical Protein Binding Ubiquitin Protein Ligase Binding Response To Starvation Regulation Of Autophagy Cellular Response To Nutrient Levels Regulation Of Synapse Organization Cytoplasm Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Negative Regulation Of Macroautophagy Negative Regulation Of Protein Localization Protein Domain Specific Binding Phosphoserine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Protein Localization To Nucleus Sodium Channel Inhibitor Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Maternal Placenta Development Cellular Response To Decreased Oxygen Levels Protein Polyubiquitination Regulation Of Protein Localization Cytoskeleton Potassium Channel Inhibitor Activity Cellular Response To Nitrogen Starvation Regulation Of Protein Localization To Nucleus Cellular Response To Oxygen Levels Response To Nutrient Levels Nuclear Envelope Lumen Anoikis TORC1 Signaling Protein Localization To Membrane Regulation Of Dendrite Morphogenesis Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of TORC1 Signaling Cellular Response To Stress Regulation Of Sodium Ion Transport Vacuole Organization Negative Regulation Of Sodium Ion Transport Phosphatidylethanolamine Binding Positive Regulation Of Catabolic Process Response To Stress Positive Regulation Of Fibroblast Migration Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis TOR Signaling Regulation Of Protein Catabolic Process Cell Projection Organization	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Regulation Of BMP Signaling Pathway Macromolecule Catabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein K11-linked Ubiquitination Regulation Of Cellular Response To Growth Factor Stimulus Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of BMP Signaling Pathway Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein K6-linked Ubiquitination Catabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleoplasm Nucleus Protein-containing Complex SMAD Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Proteolysis Phosphatase Binding Macromolecule Metabolic Process Protein Monoubiquitination Glutathione Disulfide Oxidoreductase Activity Homomeric SMAD Protein Complex TSC1-TSC2 Complex Binding Negative Regulation Of TORC1 Signaling Cellular Response To Nutrient Levels Protein Autoubiquitination Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Negative Regulation Of Signal Transduction Protein K63-linked Ubiquitination TSC1-TSC2 Complex
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