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TBC1D7 and TSC1
Number of citations of the paper that reports this interaction (PubMedID
17658474
)
0
Data Source:
HPRD
(in vivo)
TBC1D7
TSC1
Description
TBC1 domain family member 7
TSC complex subunit 1
Image
GO Annotations
Cellular Component
Cytoplasm
Lysosome
Lysosomal Membrane
Cytosol
Membrane
Cytoplasmic Vesicle
TSC1-TSC2 Complex
Ciliary Basal Body
Nucleus
Cytoplasm
Lysosome
Lysosomal Membrane
Lipid Droplet
Cytosol
Actin Filament
Plasma Membrane
Cell Cortex
Postsynaptic Density
Membrane
Lamellipodium
Protein-containing Complex
TSC1-TSC2 Complex
Ciliary Basal Body
Perinuclear Region Of Cytoplasm
Protein Folding Chaperone Complex
Molecular Function
GTPase Activator Activity
Protein Binding
Small GTPase Binding
TSC1-TSC2 Complex Binding
Protein Binding
Hsp70 Protein Binding
ATPase Inhibitor Activity
Protein Folding Chaperone
Protein-folding Chaperone Binding
Hsp90 Protein Binding
Biological Process
Cellular Response To Starvation
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of TOR Signaling
Positive Regulation Of GTPase Activity
Response To Growth Factor
Activation Of GTPase Activity
Negative Regulation Of Cilium Assembly
Negative Regulation Of TORC1 Signaling
Kidney Development
Neural Tube Closure
Regulation Of Cell-matrix Adhesion
Adaptive Immune Response
Protein Folding
Potassium Ion Transport
Cell-matrix Adhesion
Nervous System Development
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Associative Learning
Adult Locomotory Behavior
Cellular Response To Starvation
Negative Regulation Of Macroautophagy
Hippocampus Development
Cerebral Cortex Development
Cell Projection Organization
Negative Regulation Of TOR Signaling
Negative Regulation Of ATP-dependent Activity
Response To Insulin
Cellular Response To Decreased Oxygen Levels
TORC1 Signaling
Myelination
Memory T Cell Differentiation
Negative Regulation Of Cell Size
D-glucose Import
Synapse Organization
Protein Stabilization
Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Positive Regulation Of Focal Adhesion Assembly
Cardiac Muscle Cell Differentiation
Activation Of GTPase Activity
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Pathways
TBC/RABGAPs
Macroautophagy
Inhibition of TSC complex formation by PKB
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
TBC/RABGAPs
Drugs
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Migraine (
23793025
)
Migraine without aura (
23793025
)
Migraine without aura (
23793025
)
Psoriasis (
19169254
)
Interacting Genes
30 interacting genes:
AKT1
ALOX5
APP
BAG4
BLZF1
GABARAPL1
HOOK1
IKBKG
INCA1
KEAP1
KRT19
KRT35
LDOC1
LNX2
LZTS1
LZTS2
MAP1LC3A
MIPOL1
MMADHC
NEDD4
NEDD4L
PICK1
RPGRIP1
SH3GLB2
SSNA1
TRAF4
TRIM62
TSC1
XPA
YWHAZ
169 interacting genes:
ABI1
ACTN1
ACTN2
AKT1
ANKIB1
ANKRD24
ANKRD35
APPL2
AQP1
ARAF
ARID5A
ATN1
ATXN1
AURKA
AXIN1
BAG3
BCL11A
BECN1
BEND5
C1orf94
CALCOCO2
CASC3
CCDC120
CCDC88B
CCL28
CCNB1
CCND2
CCNE1
CDK1
CDK4
CDK6
CDKN2A
CDKN2B
CDR2
CHCHD2
CNIH1
CNTRL
CNTROB
COG6
CSTF2
CTNNB1
DACH2
DCTN2
DMRT3
DOK5
EIF3A
ENKD1
EZR
FAM110A
FAM222B
FBF1
FGFR4
FOXH1
FRS3
GCC1
GEMIN8
GFAP
GLIS2
GOLGA2
GPANK1
GPATCH1
HECW1
HGS
HNRNPM
HOMER3
HOOK2
HOXC8
HR
HSH2D
ICA1
IGFN1
IKBKB
KANSL2
KAT2A
KAZN
KDM1A
KIF1C
KIF5A
KLC1
KLC4
LATS2
LENG1
LMO2
LRSAM1
LUC7L
LZTS2
MAP2K5
MAPK14
MBIP
MBP
MSANTD3
MSN
MT-ND1
MYC
MYLIP
MYOZ3
NECAB2
NEFL
NF2
NINL
NKD2
NRBF2
PATL1
PATZ1
PHLDB1
PICK1
PITX1
PLK1
PLK2
POGZ
POU6F2
PPFIA2
PPP1R18
PRMT6
RALYL
RASSF1
RBPMS
RDX
RHEB
RIN1
RIN3
RUNDC3A
SAMD11
SAMD7
SAXO4
SCMH1
SEC31A
SELENOW
SERTAD1
SH2D2A
SHANK1
SHC3
SMG9
SORBS3
SOX4
SPAG5
SPAG8
SUOX
TANK
TBC1D7
TBX6
TCF7L2
TFAP2D
TFIP11
TLE5
TNS2
TRIM3
TRIOBP
TSC2
TSGA10IP
TSHZ3
USP2-AS1
VENTX
VEZF1
VGLL3
VIM
VPS37C
YPEL3
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZIC1
ZNF417
ZNF423
ZNF587
ZNF765
Entrez ID
51256
7248
HPRD ID
18165
05594
Ensembl ID
ENSG00000145979
ENSG00000165699
Uniprot IDs
Q9P0N9
U3KPY5
A0A2R8Y5M3
A0A2R8Y5N2
A0A2R8Y5S3
A0A2R8Y6S1
A0A2R8YD74
A0A2R8YFV7
Q32NF0
Q86WV8
Q92574
X5D9D2
PDB IDs
3QWL
4Z6Y
5EJC
5ULO
7DL2
9CE3
4Z6Y
5EJC
7DL2
9C9I
9CE3
Enriched GO Terms of Interacting Partners
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Cytosol
Cellular Response To Starvation
Identical Protein Binding
Ubiquitin Protein Ligase Binding
Response To Starvation
Regulation Of Autophagy
Cellular Response To Nutrient Levels
Regulation Of Synapse Organization
Cytoplasm
Regulation Of Response To Endoplasmic Reticulum Stress
Regulation Of Macroautophagy
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Macroautophagy
Negative Regulation Of Protein Localization
Protein Domain Specific Binding
Phosphoserine Residue Binding
Negative Regulation Of Potassium Ion Export Across Plasma Membrane
Negative Regulation Of Protein Localization To Nucleus
Sodium Channel Inhibitor Activity
Negative Regulation Of Response To Endoplasmic Reticulum Stress
Maternal Placenta Development
Cellular Response To Decreased Oxygen Levels
Protein Polyubiquitination
Regulation Of Protein Localization
Cytoskeleton
Potassium Channel Inhibitor Activity
Cellular Response To Nitrogen Starvation
Regulation Of Protein Localization To Nucleus
Cellular Response To Oxygen Levels
Response To Nutrient Levels
Nuclear Envelope Lumen
Anoikis
TORC1 Signaling
Protein Localization To Membrane
Regulation Of Dendrite Morphogenesis
Regulation Of Potassium Ion Export Across Plasma Membrane
Negative Regulation Of TORC1 Signaling
Cellular Response To Stress
Regulation Of Sodium Ion Transport
Vacuole Organization
Negative Regulation Of Sodium Ion Transport
Phosphatidylethanolamine Binding
Positive Regulation Of Catabolic Process
Response To Stress
Positive Regulation Of Fibroblast Migration
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Proteolysis
TOR Signaling
Regulation Of Protein Catabolic Process
Cell Projection Organization
Cytoskeleton
Protein Domain Specific Binding
Regulation Of Primary Metabolic Process
Cytoplasm
Protein Binding
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Protein Localization To Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Spindle Pole
Microtubule-based Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Microtubule Cytoskeleton Organization
Negative Regulation Of Biosynthetic Process
Protein Kinase Binding
Negative Regulation Of Macromolecule Metabolic Process
Identical Protein Binding
Cytoskeleton Organization
Organelle Organization
Negative Regulation Of Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Intracellular Transport
Cell Cycle G1/S Phase Transition
Mitotic Cell Cycle Phase Transition
Cytoskeletal Protein Binding
Cytosol
Regulation Of Protein Localization
Positive Regulation Of Protein Localization To Nucleus
Negative Regulation Of Transcription By RNA Polymerase II
Microtubule Cytoskeleton Organization Involved In Mitosis
MAPK Cascade
Cell Cycle Phase Transition
Cell Division
Positive Regulation Of Early Endosome To Late Endosome Transport
Centrosome
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