SNF8 and ELL

Number of citations: 0 (PubMedID 10419521)
Data Source: HPRD (in vitro)

		SNF8	ELL
Name		SNF8 subunit of ESCRT-II	elongation factor for RNA polymerase II
Structure
GO Annotations	Cellular Component	ESCRT II Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Late Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome	Euchromatin Nucleus Nucleoplasm Cytosol Transcription Elongation Factor Complex Cajal Body Nuclear Body Nuclear Speck Histone Locus Body
	Molecular Function	Protein Binding Lipid Binding Channel Regulator Activity Protein Homodimerization Activity	Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Phosphatase Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Protein Transport Macroautophagy Endocytic Recycling Multivesicular Body Assembly Regulation Of Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Regulation Of Protein Complex Stability Multivesicular Body Sorting Pathway Membrane Fission Positive Regulation Of Exosomal Secretion	In Utero Embryonic Development Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II SnRNA Transcription By RNA Polymerase II SnRNA Transcription By RNA Polymerase III Positive Regulation Of Transcription By RNA Polymerase III
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events Transcription-Coupled Nucleotide Excision Repair (TC-NER) TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
GWAS		Coronary heart disease ( 21378990 ) Hip circumference adjusted for BMI ( 34021172 ) Type 2 diabetes ( 29358691 )	A body shape index ( 34021172 ) Alanine aminotransferase levels ( 34315874 ) Alzheimer's disease (late onset) ( 30820047 ) Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 34315874 ) Breast cancer ( 29059683 23535729 ) Coronary artery disease ( 29212778 ) HDL cholesterol levels ( 32203549 ) Iron status biomarkers (ferritin levels) ( 33536631 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 27863252 ) Mean corpuscular hemoglobin concentration ( 32888494 27863252 ) Mean corpuscular volume ( 32888494 27863252 ) Monocyte count ( 32888494 ) Pulse pressure ( 30224653 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Waist-hip index ( 34021172 )
Novel Interactors		1 novel interactors: HMOX1	1 novel interactors: PRKACA
Interacting Genes		25 interacting genes: ADORA1 AKAP9 CHMP6 CLP1 CT55 DVL2 ELL FANCL GLYCTK GOLGA2 KDM1A NIF3L1 PRMT6 RILP SMARCD1 SUOX SUV39H2 TRIM54 TSG101 TXLNA UBC VAC14 VPS25 VPS36 YWHAE	13 interacting genes: EAF1 EAF2 EP300 HDAC3 HNRNPU MCM2 POLR2A SNF8 TFPT TP53 UBC WEE2-AS1 ZHX1
Entrez ID		11267	8178
HPRD ID		16847	02615
Ensembl ID		ENSG00000159210	ENSG00000105656
Uniprot IDs		Q96H20	P55199 U3KQ90
PDB IDs		2ZME 3CUQ	2DOA
GO Terms Enriched among Interactors		Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization Endosome Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Membrane Fission Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Receptor Activity Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome Membrane Negative Regulation Of Peptidyl-tyrosine Phosphorylation Macroautophagy Vacuolar Transport Regulation Of Protein Tyrosine Kinase Activity ESCRT II Complex Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Signaling Receptor Activity Vesicle-mediated Transport Endosomal Transport Endosome Membrane Autophagy Vesicle Organization Establishment Of Protein Localization To Vacuole Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Regulation Of ERBB Signaling Pathway Negative Regulation Of Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process Protein Localization To Vacuole Regulation Of Exosomal Secretion Establishment Of Protein Localization Viral Budding Via Host ESCRT Complex Organelle Assembly Negative Regulation Of Protein Phosphorylation Histone H3 Methyltransferase Activity Viral Budding Regulation Of Signal Transduction By P53 Class Mediator Endosome Viral Release From Host Cell Negative Regulation Of Phosphorylation Lysosomal Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Microtubule Nucleation Ubiquitin Protein Ligase Binding	Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process RNA Metabolic Process Circadian Rhythm Chromatin Remodeling Transcription Elongation By RNA Polymerase II Super Elongation Complex DNA-templated Transcription Elongation Regulation Of Primary Metabolic Process Positive Regulation Of Nucleocytoplasmic Transport Transcription Elongation Factor Activity Regulation Of DNA-templated Transcription Regulation Of Carbohydrate Catabolic Process Regulation Of RNA Biosynthetic Process Nucleus Promoter-specific Chromatin Binding Chromatin Organization Cellular Response To Parathyroid Hormone Stimulus Nucleobase-containing Compound Biosynthetic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of RNA Metabolic Process Chromatin DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Protein Transport Rhythmic Process Random Inactivation Of X Chromosome Epigenetic Regulation Of Gene Expression Regulation Of Transcription Elongation By RNA Polymerase II Response To Parathyroid Hormone Regulation Of Glucose Metabolic Process DNA Binding Regulation Of DNA-templated Transcription Elongation Ubiquitin Protein Ligase Binding Regulation Of Telomere Maintenance Regulation Of Gene Expression Negative Regulation Of Small Molecule Metabolic Process Protein Localization To Organelle Regulation Of DNA Replication Regulation Of Nucleocytoplasmic Transport Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Transcription Elongation Factor Complex Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome