SNF8 and SUV39H2

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		SNF8	SUV39H2
Description		SNF8 subunit of ESCRT-II	SUV39H2 histone lysine methyltransferase
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GO Annotations	Cellular Component	ESCRT II Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Late Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome
	Molecular Function	Protein Binding Lipid Binding Channel Regulator Activity Protein Homodimerization Activity	Transcription Cis-regulatory Region Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9 Trimethyltransferase Activity S-adenosyl-L-methionine Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Protein Transport Macroautophagy Endocytic Recycling Multivesicular Body Assembly Regulation Of Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Regulation Of Protein Complex Stability Multivesicular Body Sorting Pathway Membrane Fission Positive Regulation Of Exosomal Secretion	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Circadian Rhythm Cell Differentiation Methylation Epigenetic Programming In The Zygotic Pronuclei Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Hypoxia
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Coronary heart disease ( 21378990) Hip circumference adjusted for BMI ( 34021172) Type 2 diabetes ( 29358691)	Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		25 interacting genes: ADORA1 AKAP9 CHMP6 CLP1 CT55 DVL2 ELL FANCL GLYCTK GOLGA2 KDM1A NIF3L1 PRMT6 RILP SMARCD1 SUOX SUV39H2 TRIM54 TSG101 TXLNA UBC VAC14 VPS25 VPS36 YWHAE	43 interacting genes: AKAP9 APPL2 AR BLZF1 C8orf74 CBX7 CDCA4 CEP70 CFAP100 CGGBP1 EWSR1 FAM20C GOLGA6L9 GSTCD H3C1 ID2 KCTD17 KLF3 KLHDC4 LCA5L LNX1 LRIF1 MAGEA11 MCM3AP MRFAP1 MTF2 MYL12A NME4 ODAD3 PHF19 PNMA1 POLR3F RAB3IP RASSF1 SHC1 SMAD5 SNF8 UBE2V2 VHL WIZ ZNF212 ZNF557 ZNF57
Entrez ID		11267	79723
HPRD ID		16847	07580
Ensembl ID		ENSG00000159210	ENSG00000152455
Uniprot IDs		Q96H20	Q9H5I1
PDB IDs		2ZME 3CUQ	2R3A 6P0R
Enriched GO Terms of Interacting Partners?		Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization Endosome Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Membrane Fission Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Receptor Activity Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome Membrane Negative Regulation Of Peptidyl-tyrosine Phosphorylation Macroautophagy Vacuolar Transport Regulation Of Protein Tyrosine Kinase Activity ESCRT II Complex Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Signaling Receptor Activity Vesicle-mediated Transport Endosomal Transport Endosome Membrane Autophagy Vesicle Organization Establishment Of Protein Localization To Vacuole Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Regulation Of ERBB Signaling Pathway Negative Regulation Of Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process Protein Localization To Vacuole Regulation Of Exosomal Secretion Establishment Of Protein Localization Viral Budding Via Host ESCRT Complex Organelle Assembly Negative Regulation Of Protein Phosphorylation Histone H3 Methyltransferase Activity Viral Budding Regulation Of Signal Transduction By P53 Class Mediator Endosome Viral Release From Host Cell Negative Regulation Of Phosphorylation Lysosomal Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Microtubule Nucleation Ubiquitin Protein Ligase Binding	Nucleoplasm Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3K36me3 Reader Activity Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
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