SNF8 and CLP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SNF8	CLP1
Description		SNF8 subunit of ESCRT-II	cleavage factor polyribonucleotide kinase subunit 1
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GO Annotations	Cellular Component	ESCRT II Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Late Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome	TRNA-intron Endonuclease Complex Nucleus Nucleoplasm Cytosol MRNA Cleavage Factor Complex
	Molecular Function	Protein Binding Lipid Binding Channel Regulator Activity Protein Homodimerization Activity	Nucleotide Binding Protein Binding ATP Binding Kinase Activity Transferase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Polynucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polyribonucleotide 5'-hydroxyl-kinase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Protein Transport Macroautophagy Endocytic Recycling Multivesicular Body Assembly Regulation Of Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Regulation Of Protein Complex Stability Multivesicular Body Sorting Pathway Membrane Fission Positive Regulation Of Exosomal Secretion	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation RNA Processing MRNA Processing TRNA Processing Cerebellar Cortex Development MRNA 3'-end Processing RISC Complex Assembly Global Gene Silencing By MRNA Cleavage
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	tRNA processing in the nucleus mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Coronary heart disease ( 21378990) Hip circumference adjusted for BMI ( 34021172) Type 2 diabetes ( 29358691)	Autism spectrum disorder or schizophrenia ( 28540026) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Neuroticism ( 29255261) Schizophrenia ( 25056061 29483656)
Interacting Genes		25 interacting genes: ADORA1 AKAP9 CHMP6 CLP1 CT55 DVL2 ELL FANCL GLYCTK GOLGA2 KDM1A NIF3L1 PRMT6 RILP SMARCD1 SUOX SUV39H2 TRIM54 TSG101 TXLNA UBC VAC14 VPS25 VPS36 YWHAE	16 interacting genes: APP CEP164 CPSF3 CREB3 DAGLB FGF16 FTO HCFC1 MEOX2 MESD NUDT21 PCMT1 PRR3 PSMB5 SNF8 YJU2B
Entrez ID		11267	10978
HPRD ID		16847	16382
Ensembl ID		ENSG00000159210	ENSG00000172409
Uniprot IDs		Q96H20	Q92989
PDB IDs		2ZME 3CUQ	8HMY 8HMZ
Enriched GO Terms of Interacting Partners?		Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization Endosome Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Membrane Fission Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Receptor Activity Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome Membrane Negative Regulation Of Peptidyl-tyrosine Phosphorylation Macroautophagy Vacuolar Transport Regulation Of Protein Tyrosine Kinase Activity ESCRT II Complex Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Signaling Receptor Activity Vesicle-mediated Transport Endosomal Transport Endosome Membrane Autophagy Vesicle Organization Establishment Of Protein Localization To Vacuole Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Regulation Of ERBB Signaling Pathway Negative Regulation Of Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process Protein Localization To Vacuole Regulation Of Exosomal Secretion Establishment Of Protein Localization Viral Budding Via Host ESCRT Complex Organelle Assembly Negative Regulation Of Protein Phosphorylation Histone H3 Methyltransferase Activity Viral Budding Regulation Of Signal Transduction By P53 Class Mediator Endosome Viral Release From Host Cell Negative Regulation Of Phosphorylation Lysosomal Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Microtubule Nucleation Ubiquitin Protein Ligase Binding	Release From Viral Latency Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway MRNA Cleavage And Polyadenylation Specificity Factor Complex Positive Regulation Of Monocyte Chemotaxis Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Chemotaxis Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Chemotaxis Amylin Binding Positive Regulation Of Toll Signaling Pathway Chromatin Binding Regulation Of Monocyte Chemotaxis Positive Regulation Of Deacetylase Activity MRNA 3'-end Processing Positive Regulation Of Pro-B Cell Differentiation RNA Repair TRNA Demethylase Activity
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