RAB22A and RAB3GAP1

Number of citations of the paper that reports this interaction (PMID 16923123)
31

Data Source:
BioGRID (two hybrid)

		RAB22A	RAB3GAP1
Gene Name		RAB22A, member RAS oncogene family	RAB3 GTPase activating protein subunit 1 (catalytic)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Early Endosome Plasma Membrane Endosome Membrane Actin Cytoskeleton Phagocytic Vesicle Membrane Phagocytic Vesicle Extracellular Vesicular Exosome	Cytoplasm Protein Complex Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Rab GTPase Activator Activity Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process	Intracellular Protein Transport Endocytosis Endosome Organization Rab Protein Signal Transduction Regulation Of Vesicle Size	Brain Development Hypothalamus Development Positive Regulation Of Rab GTPase Activity Lipid Particle Organization Camera-type Eye Development Regulation Of GTPase Activity Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Excitatory Postsynaptic Membrane Potential Face Morphogenesis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization
Pathways
Drugs
Diseases
GWAS			Cholesterol, total ( 20686565) Corneal structure ( 21979947)
Protein-Protein Interactions		6 interactors: APPL2 EEA1 RAB3GAP1 RAB7A RABAC1 SMURF2	8 interactors: FEZ1 FEZ2 RAB22A RAB39A RAB39B RAB3GAP2 RPH3AL WDR7
Entrez ID		57403	22930
HPRD ID		06696	16002
Ensembl ID		ENSG00000124209	ENSG00000115839
Uniprot IDs		Q9UL26	B9A6J2 C9J837 Q15042
PDB IDs
Enriched GO Terms of Interacting Partners?		Early Endosome To Late Endosome Transport Vesicle Fusion Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Fusion Regulation Of ERBB Signaling Pathway Synaptic Vesicle To Endosome Fusion Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Epidermal Growth Factor Catabolic Process Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Membrane Fusion Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Membrane Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Endosomal Transport Vesicle Organization Signaling Phagosome-lysosome Fusion Cell Communication Regulation Of Signal Transduction Phagosome Acidification Positive Regulation Of Glutamate Secretion Regulation Of Signaling Ubiquitin-dependent SMAD Protein Catabolic Process Protein To Membrane Docking Positive Regulation Of Secretion Establishment Of Protein Localization To Organelle Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Positive Regulation Of Amino Acid Transport Protein Targeting To Lysosome Regulation Of Glutamate Secretion Regulation Of Short-term Neuronal Synaptic Plasticity Lipid Particle Organization Phagolysosome Assembly Protein Localization To Lysosome Cellular Cation Homeostasis Regulation Of Autophagic Vacuole Assembly Positive Regulation Of Neurotransmitter Secretion Forebrain Development Cellular Ion Homeostasis Cellular Copper Ion Homeostasis Regulation Of Vacuole Organization Intracellular PH Reduction Protein Localization To Organelle Protein Targeting To Vacuole PH Reduction Copper Ion Homeostasis Suckling Behavior Cellular Chemical Homeostasis Hypothalamus Development	Rab Protein Signal Transduction Intracellular Protein Transport Establishment Of Localization In Cell Cellular Localization Cellular Protein Localization Protein Transport Ras Protein Signal Transduction Establishment Of Protein Localization Intracellular Transport Protein Localization Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Vesicle Size Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Phagosome-lysosome Fusion Transport Phagosome Acidification Negative Regulation Of Macroautophagy Phagolysosome Assembly Establishment Of Mitochondrion Localization Intracellular PH Reduction Axon Guidance PH Reduction
Tagcloud ?		casein cisternae ck2alpha complemented efflux exocytic exome fragmented gap gtpase guanine huh7 ile34phe junction lucifer morphologies pyrophosphatase thiamine trafficking transferrin trf1 trf2 trf4 trf5 trf6 trf7 vsv yellow	acidic adaptor anchored binds catalytic compartment consists envelope ergic etc execute ff ffat golgi gtpase heterodimer motif phenylalanines potently recruit reduces substitution tail traffic vap vesicle
Tagcloud (Difference) ?		casein cisternae ck2alpha complemented efflux exocytic exome fragmented gap guanine huh7 ile34phe junction lucifer morphologies pyrophosphatase thiamine trafficking transferrin trf1 trf2 trf4 trf5 trf6 trf7 vsv yellow	acidic adaptor anchored binds catalytic compartment consists envelope ergic etc execute ff ffat golgi heterodimer motif phenylalanines potently recruit reduces substitution tail traffic vap vesicle
Tagcloud (Intersection) ?		gtpase