RAB22A and RAB3GAP1

Number of citations of the paper that reports this interaction (PubMedID 16923123)
0

Data Source:
BioGRID (two hybrid)

		RAB22A	RAB3GAP1
Description		RAB22A, member RAS oncogene family	RAB3 GTPase activating protein catalytic subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Endosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Endosome Membrane Endomembrane System Actin Cytoskeleton Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Phagocytic Vesicle Extracellular Exosome	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cis-Golgi Network Lipid Droplet Cytosol Protein-containing Complex Extracellular Exosome Endoplasmic Reticulum Tubular Network Postsynapse
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Intracellular Protein Transport Endocytosis Endosome Organization Protein Transport Regulation Of Vesicle Size	Brain Development Hypothalamus Development Rab Protein Signal Transduction Lipid Droplet Organization Camera-type Eye Development Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Short-term Neuronal Synaptic Plasticity Excitatory Postsynaptic Potential Face Morphogenesis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Autophagosome Assembly
Pathways		RAB geranylgeranylation	COPI-independent Golgi-to-ER retrograde traffic RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Warburg micro syndrome Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		Appendicular lean mass ( 33097823) Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Metabolite levels ( 23823483) Nickel levels ( 26025379)	Body mass index ( 25673413) Cholesterol, total ( 20686565 24097068 25961943) Corneal structure ( 21979947) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Sudden cardiac arrest in coronary artery disease ( 23593153)
Interacting Genes		7 interacting genes: ALS2CL APPL2 EEA1 RAB3GAP1 RAB7A RABAC1 SMURF2	8 interacting genes: FEZ1 FEZ2 RAB22A RAB39A RAB39B RAB3GAP2 RPH3AL WDR7
Entrez ID		57403	22930
HPRD ID		06696	16002
Ensembl ID		ENSG00000124209	ENSG00000115839
Uniprot IDs		Q9UL26	A0A8J9AUI2 B9A6J2 Q15042
PDB IDs			8VYB
Enriched GO Terms of Interacting Partners?		Cytoplasmic Vesicle Presynaptic Endosome Bounding Membrane Of Organelle Early Endosome To Late Endosome Transport Cellular Localization Endosomal Transport Small GTPase Binding Establishment Of Protein Localization To Organelle Organelle Membrane Fusion Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Lipid Droplet Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Vesicle Fusion Phagocytic Vesicle Synaptic Vesicle Recycling Via Endosome Phagocytic Vesicle Membrane Intracellular Transport Axonal Spine Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Lipophagy Glutamatergic Synapse Organelle Fusion Regulation Of Vesicle-mediated Transport Synaptic Vesicle To Endosome Fusion Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Early Phagosome Membrane Cold Acclimation Negative Regulation Of Exosomal Secretion Membrane Fusion Postsynaptic Early Endosome Chemical Synaptic Transmission, Postsynaptic Positive Regulation Of Protein Lipidation Positive Regulation Of Glutamate Secretion, Neurotransmission Cytoplasm Protein To Membrane Docking Establishment Of Localization In Cell Regulation Of Endosome Organization Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Glutamate Secretion, Neurotransmission Macropinosome Regulation Of Exocytosis Alveolar Lamellar Body Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Trophoblast Cell Migration Endosome Phagosome Acidification	Regulation Of Autophagosome Assembly Regulation Of Vacuole Organization Autolysosome Membrane Regulation Of Autophagy Negative Regulation Of Autophagosome Assembly Rab Protein Signal Transduction Protein Transport Regulation Of Macroautophagy Establishment Of Protein Localization Negative Regulation Of Macroautophagy Regulation Of Organelle Assembly Autophagy Cytoplasmic Vesicle GTPase Activity Intracellular Protein Localization Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion GTP Binding G Protein Activity Phagocytic Vesicle Membrane Phagocytic Vesicle Negative Regulation Of Autophagy Vesicle-mediated Transport Regulation Of Organelle Organization Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Intracellular Protein Transport Positive Regulation Of Protein Lipidation Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Protein Lipidation Phagosome Acidification Regulation Of Organelle Transport Along Microtubule Axon Guidance Neuron Projection Guidance Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Lipoprotein Metabolic Process Small GTPase-mediated Signal Transduction Autophagosome-lysosome Fusion Phagosome-lysosome Fusion Small GTPase Binding Myosin V Binding Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Vesicle Size Vesicle Organization Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Positive Regulation Of Autophagosome Assembly
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