RAB22A and SMURF2

Number of citations of the paper that reports this interaction (PubMedID 15761153)
0

Data Source:
HPRD (in vivo)

		RAB22A	SMURF2
Description		RAB22A, member RAS oncogene family	SMAD specific E3 ubiquitin protein ligase 2
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Endosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Endosome Membrane Endomembrane System Actin Cytoskeleton Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Phagocytic Vesicle Extracellular Exosome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Membrane Raft
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Identical Protein Binding SMAD Binding Ubiquitin Protein Ligase Activity
	Biological Process	Intracellular Protein Transport Endocytosis Endosome Organization Protein Transport Regulation Of Vesicle Size	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Trophoblast Cell Migration
Pathways		RAB geranylgeranylation	Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Asymmetric localization of PCP proteins Degradation of AXIN Hedgehog 'on' state Hedgehog 'on' state Ub-specific processing proteases Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Metabolite levels ( 23823483) Nickel levels ( 26025379)	Cardiac troponin-I levels ( 31014085) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Periodontitis (Mean PAL) ( 24024966)
Interacting Genes		7 interacting genes: ALS2CL APPL2 EEA1 RAB3GAP1 RAB7A RABAC1 SMURF2	94 interacting genes: ABRAXAS2 ACBD3 ACOX3 ADAR AIMP2 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CNKSR2 CUEDC1 DAB2 DAZAP2 DGCR2 DSCR9 EGFR EPHA1 ERBB2 FKBP4 FLNB FUBP1 GNG2 HDGFL3 ING2 IRF3 IRF8 ITGB1BP1 KLF5 LAPTM5 LATS1 LITATS1 LMNA MAVS NEK6 NKIRAS1 NRAS PARP1 PDE4B PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOD RLIM RNF11 RNF111 RNF2 RPS27A RRAS2 RTN4IP1 RUNX2 RUNX3 SF3A2 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNCA SNRNP70 SOCS6 SPART SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TOP2A TRAF2 TRAF4 TRIM28 TSSK4 TXNIP UBC UBE2D2 UBE2D3 UBE2L3 USP15 XPO1 YY1 ZBTB44
Entrez ID		57403	64750
HPRD ID		06696	06901
Ensembl ID		ENSG00000124209	ENSG00000108854
Uniprot IDs		Q9UL26	Q96DE7 Q9HAU4
PDB IDs			1ZVD 2DJY 2JQZ 2KXQ 2LTZ 6FX4 7M3Q
Enriched GO Terms of Interacting Partners?		Cytoplasmic Vesicle Presynaptic Endosome Bounding Membrane Of Organelle Early Endosome To Late Endosome Transport Cellular Localization Endosomal Transport Small GTPase Binding Establishment Of Protein Localization To Organelle Organelle Membrane Fusion Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Lipid Droplet Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Vesicle Fusion Phagocytic Vesicle Synaptic Vesicle Recycling Via Endosome Phagocytic Vesicle Membrane Intracellular Transport Axonal Spine Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Lipophagy Glutamatergic Synapse Organelle Fusion Regulation Of Vesicle-mediated Transport Synaptic Vesicle To Endosome Fusion Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Early Phagosome Membrane Cold Acclimation Negative Regulation Of Exosomal Secretion Membrane Fusion Postsynaptic Early Endosome Chemical Synaptic Transmission, Postsynaptic Positive Regulation Of Protein Lipidation Positive Regulation Of Glutamate Secretion, Neurotransmission Cytoplasm Protein To Membrane Docking Establishment Of Localization In Cell Regulation Of Endosome Organization Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Glutamate Secretion, Neurotransmission Macropinosome Regulation Of Exocytosis Alveolar Lamellar Body Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Trophoblast Cell Migration Endosome Phagosome Acidification	Ubiquitin Protein Ligase Binding I-SMAD Binding Heteromeric SMAD Protein Complex Response To Growth Factor Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Protein-containing Complex Negative Regulation Of RNA Metabolic Process GTPase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process GDP Binding Negative Regulation Of Transcription By RNA Polymerase II GTP Binding Nucleoplasm Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytosol Negative Regulation Of Signal Transduction SMAD Protein Complex Cell Surface Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Cell Development Regulation Of RNA Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Transcription Regulator Complex Ureteric Bud Development Negative Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Response To Transforming Growth Factor Beta Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Osteoblast Fate Commitment Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Mesonephric Tubule Development Cellular Developmental Process Intracellular Signal Transduction Mesonephric Epithelium Development Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process R-SMAD Binding
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