RAB22A and ALS2CL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RAB22A	ALS2CL
Description		RAB22A, member RAS oncogene family	ALS2 C-terminal like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ruffle Endosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Endosome Membrane Endomembrane System Actin Cytoskeleton Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Phagocytic Vesicle Extracellular Exosome	Cytoplasm Cytosol Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Intracellular Protein Transport Endocytosis Endosome Organization Protein Transport Regulation Of Vesicle Size	Endosomal Transport
Pathways		RAB geranylgeranylation	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Metabolite levels ( 23823483) Nickel levels ( 26025379)
Interacting Genes		7 interacting genes: ALS2CL APPL2 EEA1 RAB3GAP1 RAB7A RABAC1 SMURF2	7 interacting genes: EEF1AKMT3 RAB22A RAB31 RAB5A RAB5C RSPH14 SAXO4
Entrez ID		57403	259173
HPRD ID		06696	10643
Ensembl ID		ENSG00000124209	ENSG00000178038
Uniprot IDs		Q9UL26	Q60I27
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoplasmic Vesicle Presynaptic Endosome Bounding Membrane Of Organelle Early Endosome To Late Endosome Transport Cellular Localization Endosomal Transport Small GTPase Binding Establishment Of Protein Localization To Organelle Organelle Membrane Fusion Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Lipid Droplet Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Vesicle Fusion Phagocytic Vesicle Synaptic Vesicle Recycling Via Endosome Phagocytic Vesicle Membrane Intracellular Transport Axonal Spine Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Lipophagy Glutamatergic Synapse Organelle Fusion Regulation Of Vesicle-mediated Transport Synaptic Vesicle To Endosome Fusion Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Early Phagosome Membrane Cold Acclimation Negative Regulation Of Exosomal Secretion Membrane Fusion Postsynaptic Early Endosome Chemical Synaptic Transmission, Postsynaptic Positive Regulation Of Protein Lipidation Positive Regulation Of Glutamate Secretion, Neurotransmission Cytoplasm Protein To Membrane Docking Establishment Of Localization In Cell Regulation Of Endosome Organization Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Glutamate Secretion, Neurotransmission Macropinosome Regulation Of Exocytosis Alveolar Lamellar Body Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Trophoblast Cell Migration Endosome Phagosome Acidification	GDP Binding Early Endosome Endomembrane System GTPase Activity Phagocytic Vesicle Phagocytic Vesicle Membrane Plasma Membrane To Endosome Transport GTP Binding Endocytosis Regulation Of Vesicle Size Intracellular Protein Transport Import Into Cell Early Endosome Membrane Endosome Receptor Internalization Endocytic Vesicle G Protein Activity Protein Transport Endosome Organization Vesicle-mediated Transport Intracellular Transport Melanosome Ruffle Cell Projection Establishment Of Protein Localization Regulation Of Vesicle-mediated Transport Protein Localization To Early Endosome Early Phagosome Membrane Cytoplasmic Side Of Early Endosome Membrane Cellular Localization Late Endosome Establishment Of Localization In Cell Receptor-mediated Endocytosis Nucleotide Binding Amyloid-beta Clearance By Transcytosis Intracellular Protein Localization Motile Cilium Cytoplasmic Vesicle Regulation Of Cellular Component Size Regulation Of Endosome Size Endosomal Transport Phagosome Maturation Early Phagosome Radial Spoke Actin Cytoskeleton Endosome Membrane Protein Localization To Endosome Positive Regulation Of Phagocytosis, Engulfment Synaptic Vesicle Recycling Somatodendritic Compartment
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