RAB22A and APPL2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		RAB22A	APPL2
Gene Name		RAB22A, member RAS oncogene family	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Early Endosome Plasma Membrane Endosome Membrane Actin Cytoskeleton Phagocytic Vesicle Membrane Phagocytic Vesicle Extracellular Vesicular Exosome	Nucleus Cytoplasm Endosome Membrane NuRD Complex Early Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Protein Binding
	Biological Process	Intracellular Protein Transport Endocytosis Endosome Organization Rab Protein Signal Transduction Regulation Of Vesicle Size	Cell Cycle Signal Transduction Cell Proliferation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APPL2 EEA1 RAB3GAP1 RAB7A RABAC1 SMURF2	11 interactors: APPL1 CRADD MTA2 POT1 RAB22A RAB5A RAB5C RBBP7 RUVBL2 SUV39H2 TINF2
Entrez ID		57403	55198
HPRD ID		06696	06945
Ensembl ID		ENSG00000124209	ENSG00000136044
Uniprot IDs		Q9UL26	Q8NEU8
PDB IDs			4H8S
Enriched GO Terms of Interacting Partners?		Early Endosome To Late Endosome Transport Vesicle Fusion Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Fusion Regulation Of ERBB Signaling Pathway Synaptic Vesicle To Endosome Fusion Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Epidermal Growth Factor Catabolic Process Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Membrane Fusion Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Membrane Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Endosomal Transport Vesicle Organization Signaling Phagosome-lysosome Fusion Cell Communication Regulation Of Signal Transduction Phagosome Acidification Positive Regulation Of Glutamate Secretion Regulation Of Signaling Ubiquitin-dependent SMAD Protein Catabolic Process Protein To Membrane Docking Positive Regulation Of Secretion Establishment Of Protein Localization To Organelle Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Positive Regulation Of Amino Acid Transport Protein Targeting To Lysosome Regulation Of Glutamate Secretion Regulation Of Short-term Neuronal Synaptic Plasticity Lipid Particle Organization Phagolysosome Assembly Protein Localization To Lysosome Cellular Cation Homeostasis Regulation Of Autophagic Vacuole Assembly Positive Regulation Of Neurotransmitter Secretion Forebrain Development Cellular Ion Homeostasis Cellular Copper Ion Homeostasis Regulation Of Vacuole Organization Intracellular PH Reduction Protein Localization To Organelle Protein Targeting To Vacuole PH Reduction Copper Ion Homeostasis Suckling Behavior Cellular Chemical Homeostasis Hypothalamus Development	Chromatin Remodeling Chromosome Organization Rab Protein Signal Transduction Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Chromatin Assembly Or Disassembly DNA Metabolic Process Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Chromatin Modification Ras Protein Signal Transduction Organelle Organization Negative Regulation Of Biosynthetic Process Cellular Protein Localization Negative Regulation Of DNA Replication Chromatin Organization DNA Conformation Change Telomere Maintenance ATP-dependent Chromatin Remodeling Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of DNA Strand Elongation Regulation Of Cellular Process DNA Duplex Unwinding DNA Geometric Change Histone Modification Positive Regulation Of Organelle Organization Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Regulation Of Protein ADP-ribosylation Regulation Of Vesicle Size Cellular Heat Acclimation Protein Localization Response To Abiotic Stimulus Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Telomere Formation Via Telomerase Negative Regulation Of Estrogen Receptor Binding Transcriptional Activation By Promoter-enhancer Looping Negative Regulation Of Cellular Metabolic Process Regulation Of DNA Replication Negative Regulation Of Protein Glycosylation Positive Regulation Of DNA Metabolic Process Histone H3-K9 Dimethylation Small GTPase Mediated Signal Transduction
Tagcloud ?		casein cisternae ck2alpha complemented efflux exocytic exome fragmented gap gtpase guanine huh7 ile34phe junction lucifer morphologies pyrophosphatase thiamine trafficking transferrin trf1 trf2 trf4 trf5 trf6 trf7 vsv yellow	adaptor alanine appl1 bar conditional diminishes elusive evoked fine glut4 gtpase homolog hyperglycemia likewise muscles myotubes partner potentiates rab serine skeletal stimulates substitution suppresses suppressive tbc1d1 threonine tune uptake
Tagcloud (Difference) ?		casein cisternae ck2alpha complemented efflux exocytic exome fragmented gap guanine huh7 ile34phe junction lucifer morphologies pyrophosphatase thiamine trafficking transferrin trf1 trf2 trf4 trf5 trf6 trf7 vsv yellow	adaptor alanine appl1 bar conditional diminishes elusive evoked fine glut4 homolog hyperglycemia likewise muscles myotubes partner potentiates rab serine skeletal stimulates substitution suppresses suppressive tbc1d1 threonine tune uptake
Tagcloud (Intersection) ?		gtpase