ULK1 and C1QBP

Number of citations of the paper that reports this interaction (PubMedID 25909887)
26

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ULK1	C1QBP
Description		unc-51 like autophagy activating kinase 1	complement C1q binding protein
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Autophagosome Membrane Cytoplasm Mitochondrial Outer Membrane Autophagosome Endoplasmic Reticulum Membrane Cytosol Axon Phagophore Assembly Site Membrane Recycling Endosome Omegasome Membrane Atg1/ULK1 Kinase Complex	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Cell Surface Membrane Presynaptic Active Zone Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding GTPase Binding Protein Serine Kinase Activity	Complement Component C1q Complex Binding Transcription Corepressor Activity MRNA Binding Enzyme Inhibitor Activity Protein Kinase C Binding Protein Binding Hyaluronic Acid Binding Transcription Factor Binding Kininogen Binding Adrenergic Receptor Binding Deoxyribonuclease Inhibitor Activity C5-methylcytidine-containing RNA Reader Activity Mitochondrial Ribosome Binding
	Biological Process	Autophagosome Assembly Mitophagy Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Signal Transduction Axonogenesis Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Autophagy Positive Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Macroautophagy Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Cellular Response To Nutrient Levels Cellular Response To Stress Piecemeal Microautophagy Of The Nucleus Response To Starvation Protein Autophosphorylation Negative Regulation Of Collateral Sprouting Axon Extension Reticulophagy Protein-containing Complex Assembly Positive Regulation Of Autophagosome Assembly	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Mitochondrial RNA Catabolic Process Adaptive Immune Response Immune System Process MRNA Processing Apoptotic Process Immune Response Complement Activation, Classical Pathway DNA Damage Response RNA Splicing Regulation Of Complement Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Ribosome Biogenesis Cytosolic Ribosome Assembly Positive Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Innate Immune Response Positive Regulation Of Cell Adhesion Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Defense Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Translation Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Trophoblast Cell Migration Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Dendritic Cell Chemotaxis
Pathways		Macroautophagy Regulation of TNFR1 signaling TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs Receptor Mediated Mitophagy	Apoptotic factor-mediated response Intrinsic Pathway of Fibrin Clot Formation RHOA GTPase cycle RHOC GTPase cycle Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function
Drugs		Fostamatinib	Hyaluronic acid Copper
Diseases
GWAS		Body mass index ( 26426971) Mercury levels ( 26025379)	Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		25 interacting genes: ATG13 BECN1 C1QBP CALCOCO2 EXOC8 GABARAP GABARAPL2 KLHL20 MAPK14 MBP MEFV MTOR MUL1 NEDD4L OCLN PEDS1 PPP1CA PRKAA1 RIPK2 SDCBP SMCR8 STAMBP SYNGAP1 UBC USP20	105 interacting genes: C1QA CDK13 CEBPA COIL DUX4 EXOSC6 FOXP1 GAB1 GABRB1 HABP4 HMGB1 HMGB2 HNRNPD HRK KLF1 MAPK1 MAPK3 MBD1 MBD2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MMP14 NFKBIE NFYB PRKCA PRKCD PRKCZ PRKD1 PRRC2A SHANK3 SRSF1 SRSF9 TOP3B ULK1 YWHAB YWHAG
Entrez ID		8408	708
HPRD ID		11933	03168
Ensembl ID		ENSG00000177169	ENSG00000108561
Uniprot IDs		O75385	Q07021
PDB IDs		4WNO 4WNP 5CI7 6HYO 6MNH 6QAS 8P5G 8P5H 8P5I 8P5J 8P5K 8P5L 8SOI 8SQZ 8SRM 8SV9 9C82 9F32	1P32 3RPX 6SZW 7TE3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Autophagy Regulation Of Autophagy Positive Regulation Of Catabolic Process Autophagy Autophagosome Macroautophagy Autophagosome Assembly Autophagosome Organization Regulation Of Macroautophagy Positive Regulation Of Metabolic Process Vacuole Organization Intracellular Signaling Cassette Cytosol Positive Regulation Of Cellular Component Organization Apoptotic Process Positive Regulation Of Macroautophagy Cellular Response To Nitrogen Starvation Programmed Cell Death Cell Death Positive Regulation Of Organelle Organization Negative Regulation Of Intracellular Signal Transduction Catabolic Process Mitophagy Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-12 Production Autophagy Of Mitochondrion Regulation Of Immune Response P38MAPK Cascade Cellular Response To Starvation Cellular Response To Stress Negative Regulation Of Lysosome Organization Regulation Of Metabolic Process Regulation Of Chemokine Production Negative Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Catabolic Process Regulation Of Cellular Component Organization Response To Starvation Positive Regulation Of Protein-containing Complex Disassembly Post-translational Protein Modification Negative Regulation Of Macroautophagy Organelle Organization Regulation Of Signal Transduction Positive Regulation Of Growth Response To Mitochondrial Depolarisation Regulation Of Organelle Assembly Cellular Response To Nutrient Levels Regulation Of Protein Metabolic Process Regulation Of Innate Immune Response Xenophagy	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Regulation Of Macromolecule Metabolic Process Regulation Of Angiogenesis Positive Regulation Of MRNA Catabolic Process Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of RNA Stability Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Angiogenesis Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Vasculature Development Regulation Of Cell Migration Regulation Of Cell Motility Negative Regulation Of Developmental Process Regulation Of Locomotion Regulation Of MRNA Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Developmental Process Negative Regulation Of Blood Vessel Endothelial Cell Migration
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