ULK1 and ATG13

Number of citations of the paper that reports this interaction (PubMedID 36736316)
80

Data Source:
BioGRID (pull down, affinity chromatography technology, enzymatic study)

		ULK1	ATG13
Description		unc-51 like autophagy activating kinase 1	autophagy related 13
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Autophagosome Membrane Cytoplasm Mitochondrial Outer Membrane Autophagosome Endoplasmic Reticulum Membrane Cytosol Axon Phagophore Assembly Site Membrane Recycling Endosome Omegasome Membrane Atg1/ULK1 Kinase Complex	Phagophore Assembly Site Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Membrane Cytosol Phagophore Assembly Site Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding GTPase Binding Protein Serine Kinase Activity	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Autophagosome Assembly Mitophagy Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Signal Transduction Axonogenesis Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Autophagy Positive Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Macroautophagy Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Cellular Response To Nutrient Levels Cellular Response To Stress Piecemeal Microautophagy Of The Nucleus Response To Starvation Protein Autophosphorylation Negative Regulation Of Collateral Sprouting Axon Extension Reticulophagy Protein-containing Complex Assembly Positive Regulation Of Autophagosome Assembly	Autophagosome Assembly Mitophagy Autophagy Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Protein Localization To Phagophore Assembly Site Piecemeal Microautophagy Of The Nucleus Regulation Of Cell Population Proliferation Response To Mitochondrial Depolarisation Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Macroautophagy Regulation of TNFR1 signaling TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs Receptor Mediated Mitophagy	Macroautophagy
Drugs		Fostamatinib
Diseases
GWAS		Body mass index ( 26426971) Mercury levels ( 26025379)	Age at first sexual intercourse ( 27089180) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Headache ( 29397368) Immunoglobulin A ( 20694011) Reaction time ( 29844566) Schizophrenia ( 29483656) Selective IgA deficiency ( 27723758)
Interacting Genes		25 interacting genes: ATG13 BECN1 C1QBP CALCOCO2 EXOC8 GABARAP GABARAPL2 KLHL20 MAPK14 MBP MEFV MTOR MUL1 NEDD4L OCLN PEDS1 PPP1CA PRKAA1 RIPK2 SDCBP SMCR8 STAMBP SYNGAP1 UBC USP20	13 interacting genes: APP ATG101 ATG14 GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C OTOS RNF31 SMCR8 ULK1
Entrez ID		8408	9776
HPRD ID		11933	13809
Ensembl ID		ENSG00000177169	ENSG00000175224
Uniprot IDs		O75385	A8K0S6 O75143
PDB IDs		4WNO 4WNP 5CI7 6HYO 6MNH 6QAS 8P5G 8P5H 8P5I 8P5J 8P5K 8P5L 8SOI 8SQZ 8SRM 8SV9 9C82 9F32	3WAN 3WAO 3WAP 5C50 5XUY 5XV1 5XV3 5XV4 5XV6 6HYN 8DO8 8SOI 8SQZ 8SRM 9C82
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Autophagy Regulation Of Autophagy Positive Regulation Of Catabolic Process Autophagy Autophagosome Macroautophagy Autophagosome Assembly Autophagosome Organization Regulation Of Macroautophagy Positive Regulation Of Metabolic Process Vacuole Organization Intracellular Signaling Cassette Cytosol Positive Regulation Of Cellular Component Organization Apoptotic Process Positive Regulation Of Macroautophagy Cellular Response To Nitrogen Starvation Programmed Cell Death Cell Death Positive Regulation Of Organelle Organization Negative Regulation Of Intracellular Signal Transduction Catabolic Process Mitophagy Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-12 Production Autophagy Of Mitochondrion Regulation Of Immune Response P38MAPK Cascade Cellular Response To Starvation Cellular Response To Stress Negative Regulation Of Lysosome Organization Regulation Of Metabolic Process Regulation Of Chemokine Production Negative Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Catabolic Process Regulation Of Cellular Component Organization Response To Starvation Positive Regulation Of Protein-containing Complex Disassembly Post-translational Protein Modification Negative Regulation Of Macroautophagy Organelle Organization Regulation Of Signal Transduction Positive Regulation Of Growth Response To Mitochondrial Depolarisation Regulation Of Organelle Assembly Cellular Response To Nutrient Levels Regulation Of Protein Metabolic Process Regulation Of Innate Immune Response Xenophagy	Mitophagy Autophagosome Membrane Autophagosome Organization Autophagosome Assembly Cellular Response To Nitrogen Starvation Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Autophagosome Autophagy Vacuole Organization Autophagosome Maturation Macroautophagy Response To Starvation Cellular Response To Nutrient Levels Protein-containing Complex Disassembly Cellular Response To Starvation Phospholipid Binding Organelle Assembly Response To Nutrient Levels Ubiquitin Protein Ligase Binding Atg1/ULK1 Kinase Complex Cytoplasmic Vesicle Catabolic Process Protein-containing Complex Organization GABA Receptor Binding Cellular Component Assembly Phagophore Assembly Site Positive Regulation Of Catabolic Process Microtubule Beta-tubulin Binding Cellular Response To Stress Organelle Membrane Regulation Of Autophagy Response To Stress Positive Regulation Of Autophagy Regulation Of Macroautophagy Organelle Organization Microtubule Binding Endomembrane System Positive Regulation Of Macroautophagy Response To Lead Ion Axoneme Cytosol Phagophore Assembly Site Membrane Cellular Response To Copper Ion Cytoplasm Response To Copper Ion GTPase Binding Regulation Of Autophagosome Assembly Amyloid-beta Complex
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