GABARAP and GABRG3

Number of citations of the paper that reports this interaction (PubMedID 11948245)
0

Data Source:
HPRD (in vitro, in vivo)

		GABARAP	GABRG3
Description		GABA type A receptor-associated protein	gamma-aminobutyric acid type A receptor subunit gamma3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Cytoplasm Lysosome Autophagosome Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Endomembrane System Actin Cytoskeleton Membrane Cytoplasmic Vesicle Sperm Midpiece GABA-ergic Synapse	Nucleolus Plasma Membrane Microtubule Cytoskeleton Membrane Dendrite Membrane Chloride Channel Complex Synapse Postsynaptic Membrane Synaptic Membrane Postsynapse GABA-ergic Synapse GABA-A Receptor Complex
	Molecular Function	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Autophagosome Assembly Microtubule Cytoskeleton Organization Mitophagy Protein Targeting Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Chemical Synaptic Transmission Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Rac Protein Signal Transduction Autophagosome Maturation Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein K48-linked Ubiquitination	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Response To Xenobiotic Stimulus Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		Macroautophagy TBC/RABGAPs	Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs			Lorazepam Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Olanzapine Clobazam Clobazam Meprobamate Eszopiclone Alprazolam Alprazolam Metharbital Chlordiazepoxide Chlordiazepoxide Amoxapine Adinazolam Adinazolam Lamotrigine Lamotrigine Medroxyprogesterone acetate Clorazepic acid Clorazepic acid Midazolam Midazolam Flurazepam Flurazepam Isoflurane Primidone Halazepam Halazepam Propofol Diazepam Diazepam Oxazepam Oxazepam Triazolam Triazolam Ethanol Zonisamide Methoxyflurane Memantine Clonazepam Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Estazolam Sevoflurane Glutethimide Camazepam Camazepam Delorazepam Delorazepam Flunitrazepam Flunitrazepam Ethyl loflazepate Ethyl loflazepate Cloxazolam Cloxazolam Bromazepam Bromazepam Clotiazepam Clotiazepam Fludiazepam Ketazolam Ketazolam Prazepam Prazepam Quazepam Quazepam Cinolazepam Cinolazepam Nitrazepam Nitrazepam Prasterone Taurine Ganaxolone Adipiplon Brotizolam Brotizolam Stiripentol Etizolam Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Remimazolam 1,2-Benzodiazepine 1,2-Benzodiazepine Pinazepam Pinazepam Medazepam Medazepam Loprazolam Loprazolam Doxefazepam Doxefazepam Lormetazepam Lormetazepam 5,7,2′-trihydroxy-6,8-dimethoxyflavone Nordazepam Nordazepam Oxazepam acetate Oxazepam acetate Cinazepam Cinazepam Bentazepam Bentazepam Mexazolam Mexazolam
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514)	Alzheimer's disease (cognitive decline) ( 23535033) Anthropometric traits (multi-trait analysis) ( 30166351) Asthma and eczema ( 34155719) Bitter beverage consumption ( 31046077) Corneal curvature ( 22969067) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Gene methylation in lung tissue ( 25713168) General risk tolerance (MTAG) ( 30643258) High-grade serous ovarian cancer ( 31469419) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Type 2 diabetes ( 30130595) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737) Weight ( 28552196)
Interacting Genes		75 interacting genes: AMBRA1 ANK2 ANK3 APPL1 ATG101 ATG13 ATG3 ATG4B ATG4C ATG4D ATG7 ATXN3 AZI2 BICC1 BIRC6 CARS2 CCT2 CDC37 CUL3 DMPK DVL2 FLCN G3BP1 GABRG1 GABRG2 GABRG3 GJA1 GPHN HDAC5 KBTBD7 KDR LMNB1 MAP4K2 MAPK15 MEFV MIB1 MLH1 MPC1 MTX1 MYBPC1 MYBPC2 NBR1 NCOR1 NEDD4 NEK9 NSF NUFIP2 OPTN PCM1 PGS1 PKP4 PRKCZ RB1CC1 RESF1 SAMM50 SEC62 SNX18 SRPK1 SRPK2 STK3 TAX1BP1 TBC1D25 TFRC TLE5 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 TSR2 TTN TUBB3 ULK1 ULK2 VPS28	1 interacting genes: GABARAP
Entrez ID		11337	2567
HPRD ID		05496	02579
Ensembl ID		ENSG00000170296	ENSG00000182256
Uniprot IDs		O95166 Q6IAW1	Q99928
PDB IDs		1GNU 1KLV 1KM7 1KOT 3D32 3DOW 3WIM 4XC2 5DPS 6HB9 6HOG 6HOH 6HOJ 6HOK 6HYL 6HYM 6HYN 6HYO 6YOP 7AA8 7BRQ 7BRT 7BRU 7BV4 7EA7 7LSW 7LT6 7VEC 7VED 7YO9 7ZKR 7ZL7 8AFI 8S1M 8T2M 8T2N 8T31 8T32 8T33 8W6A
Enriched GO Terms of Interacting Partners?		Autophagosome Autophagosome Assembly Autophagosome Organization Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Autophagy Autophagy Of Mitochondrion Positive Regulation Of Autophagy Regulation Of Autophagy Microautophagy Macroautophagy Positive Regulation Of Catabolic Process Intracellular Protein Localization Mitophagy Organelle Organization Cellular Component Assembly Cytoplasm Organelle Assembly Protein Modification Process Cytosol Positive Regulation Of Metabolic Process Catabolic Process Cytoplasmic Vesicle Atg1/ULK1 Kinase Complex M Band Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Protein Phosphorylation Protein-phosphatidylethanolamide Deconjugating Activity Establishment Of Protein Localization Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Transport Regulation Of Cell Communication Protein Delipidation Phosphorylation Protein Serine/threonine Kinase Activity Protein Kinase Activity Protein Metabolic Process Regulation Of Signaling Regulation Of Intracellular Signal Transduction Phagophore Assembly Site Membrane Protein Localization To Organelle Defense Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Junction Organization Response To Starvation	Regulation Of Protein K48-linked Ubiquitination Phosphatidylethanolamine Binding GABA Receptor Binding Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Smooth Endoplasmic Reticulum Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Cellular Response To Nitrogen Starvation Regulation Of Protein Polyubiquitination Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Regulation Of Rac Protein Signal Transduction Microtubule Associated Complex Beta-tubulin Binding Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Autophagosome Maturation Sperm Midpiece Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Extrinsic Apoptotic Signaling Pathway Phospholipid Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Autophagosome Organization Autophagosome Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process GABA-ergic Synapse Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Axoneme Positive Regulation Of Proteasomal Protein Catabolic Process Protein-containing Complex Disassembly Regulation Of Protein Localization To Cell Periphery Macroautophagy Vacuole Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization To Membrane Cellular Response To Starvation Positive Regulation Of Proteolysis Regulation Of Protein Ubiquitination Protein Targeting Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Starvation Regulation Of Post-translational Protein Modification Microtubule Binding Cellular Response To Nutrient Levels
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