GABARAP and MEFV

Number of citations of the paper that reports this interaction (PubMedID 26347139)
99

Data Source:
BioGRID (pull down)

		GABARAP	MEFV
Description		GABA type A receptor-associated protein	MEFV innate immunity regulator, pyrin
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GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Cytoplasm Lysosome Autophagosome Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Endomembrane System Actin Cytoskeleton Membrane Cytoplasmic Vesicle Sperm Midpiece GABA-ergic Synapse	Ruffle Nucleus Cytoplasm Autophagosome Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Lamellipodium Cytoplasmic Vesicle Cell Projection Canonical Inflammasome Complex
	Molecular Function	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding	Actin Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Autophagosome Assembly Microtubule Cytoskeleton Organization Mitophagy Protein Targeting Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Chemical Synaptic Transmission Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Rac Protein Signal Transduction Autophagosome Maturation Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein K48-linked Ubiquitination	Pattern Recognition Receptor Signaling Pathway Immune System Process Inflammatory Response Regulation Of Gene Expression Positive Regulation Of Autophagy Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-1 Beta Production Response To Type II Interferon Innate Immune Response Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Response To Other Organism Pyroptotic Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Pyroptosome Complex Assembly
Pathways		Macroautophagy TBC/RABGAPs	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases			Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514)	Ankylosing spondylitis ( 30946743)
Interacting Genes		75 interacting genes: AMBRA1 ANK2 ANK3 APPL1 ATG101 ATG13 ATG3 ATG4B ATG4C ATG4D ATG7 ATXN3 AZI2 BICC1 BIRC6 CARS2 CCT2 CDC37 CUL3 DMPK DVL2 FLCN G3BP1 GABRG1 GABRG2 GABRG3 GJA1 GPHN HDAC5 KBTBD7 KDR LMNB1 MAP4K2 MAPK15 MEFV MIB1 MLH1 MPC1 MTX1 MYBPC1 MYBPC2 NBR1 NCOR1 NEDD4 NEK9 NSF NUFIP2 OPTN PCM1 PGS1 PKP4 PRKCZ RB1CC1 RESF1 SAMM50 SEC62 SNX18 SRPK1 SRPK2 STK3 TAX1BP1 TBC1D25 TFRC TLE5 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 TSR2 TTN TUBB3 ULK1 ULK2 VPS28	12 interacting genes: COG5 GABARAP GABARAPL1 GABARAPL2 LGALS3 LGALS8 MAP1LC3A MAP1LC3C PSTPIP1 PYCARD SIVA1 ULK1
Entrez ID		11337	4210
HPRD ID		05496	02012
Ensembl ID		ENSG00000170296	ENSG00000103313
Uniprot IDs		O95166 Q6IAW1	D2DTW2 O15553
PDB IDs		1GNU 1KLV 1KM7 1KOT 3D32 3DOW 3WIM 4XC2 5DPS 6HB9 6HOG 6HOH 6HOJ 6HOK 6HYL 6HYM 6HYN 6HYO 6YOP 7AA8 7BRQ 7BRT 7BRU 7BV4 7EA7 7LSW 7LT6 7VEC 7VED 7YO9 7ZKR 7ZL7 8AFI 8S1M 8T2M 8T2N 8T31 8T32 8T33 8W6A	2MPC 2WL1 4CG4 8C28 8C2Y 8C30 8SDJ
Enriched GO Terms of Interacting Partners?		Autophagosome Autophagosome Assembly Autophagosome Organization Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Autophagy Autophagy Of Mitochondrion Positive Regulation Of Autophagy Regulation Of Autophagy Microautophagy Macroautophagy Positive Regulation Of Catabolic Process Intracellular Protein Localization Mitophagy Organelle Organization Cellular Component Assembly Cytoplasm Organelle Assembly Protein Modification Process Cytosol Positive Regulation Of Metabolic Process Catabolic Process Cytoplasmic Vesicle Atg1/ULK1 Kinase Complex M Band Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Protein Phosphorylation Protein-phosphatidylethanolamide Deconjugating Activity Establishment Of Protein Localization Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Transport Regulation Of Cell Communication Protein Delipidation Phosphorylation Protein Serine/threonine Kinase Activity Protein Kinase Activity Protein Metabolic Process Regulation Of Signaling Regulation Of Intracellular Signal Transduction Phagophore Assembly Site Membrane Protein Localization To Organelle Defense Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Junction Organization Response To Starvation	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Membrane Mitophagy Macroautophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Autophagosome Organization Autophagosome Maturation Autophagy Vacuole Organization Response To Starvation Cellular Response To Nutrient Levels Phospholipid Binding Protein-containing Complex Disassembly Cellular Response To Starvation GABA Receptor Binding Response To Nutrient Levels Ubiquitin Protein Ligase Binding Microtubule Beta-tubulin Binding Organelle Assembly Cytoplasmic Vesicle Protein-containing Complex Organization Cytoplasm Cytosol Cellular Response To Stress Response To Stress Organelle Organization Catabolic Process Intra-Golgi Vesicle-mediated Transport Cellular Component Assembly Organelle Membrane Microtubule Binding CD27 Receptor Binding Myosin I Binding Endomembrane System Golgi Membrane Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Omegasome Membrane Inter-Golgi Cisterna Vesicle-mediated Transport Golgi Apparatus Apoptotic Signaling Pathway NLRP6 Inflammasome Complex Pyrin Domain Binding Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Negative Regulation Of NK T Cell Activation
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