GABARAP and SAMM50

Number of citations of the paper that reports this interaction (PubMedID 34037656)
114

Data Source:
BioGRID (pull down)

		GABARAP	SAMM50
Description		GABA type A receptor-associated protein	SAMM50 sorting and assembly machinery component
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GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Cytoplasm Lysosome Autophagosome Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Endomembrane System Actin Cytoskeleton Membrane Cytoplasmic Vesicle Sperm Midpiece GABA-ergic Synapse	SAM Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Outer Membrane Extracellular Exosome MIB Complex
	Molecular Function	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding	Protein Binding
	Biological Process	Autophagosome Assembly Microtubule Cytoskeleton Organization Mitophagy Protein Targeting Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Chemical Synaptic Transmission Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Rac Protein Signal Transduction Autophagosome Maturation Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein K48-linked Ubiquitination	Inner Mitochondrial Membrane Organization Protein Import Into Mitochondrial Matrix Cristae Formation Protein Insertion Into Mitochondrial Outer Membrane
Pathways		Macroautophagy TBC/RABGAPs	Mitochondrial protein import Cristae formation RAC2 GTPase cycle
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514)	Alanine aminotransferase levels ( 30718733) Cholesterol, total ( 26780889) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757) Metabolite levels ( 23823483) Nonalcoholic fatty liver disease ( 22719876 29271184 29385134 34841290) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Total cholesterol levels ( 28334899) Type 2 diabetes ( 30054458)
Interacting Genes		75 interacting genes: AMBRA1 ANK2 ANK3 APPL1 ATG101 ATG13 ATG3 ATG4B ATG4C ATG4D ATG7 ATXN3 AZI2 BICC1 BIRC6 CARS2 CCT2 CDC37 CUL3 DMPK DVL2 FLCN G3BP1 GABRG1 GABRG2 GABRG3 GJA1 GPHN HDAC5 KBTBD7 KDR LMNB1 MAP4K2 MAPK15 MEFV MIB1 MLH1 MPC1 MTX1 MYBPC1 MYBPC2 NBR1 NCOR1 NEDD4 NEK9 NSF NUFIP2 OPTN PCM1 PGS1 PKP4 PRKCZ RB1CC1 RESF1 SAMM50 SEC62 SNX18 SRPK1 SRPK2 STK3 TAX1BP1 TBC1D25 TFRC TLE5 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 TSR2 TTN TUBB3 ULK1 ULK2 VPS28	10 interacting genes: A1BG CHCHD3 CHCHD6 GABARAP HMGB2 MAP1LC3B MAP1LC3C MEOX2 UBC VDAC1
Entrez ID		11337	25813
HPRD ID		05496	10826
Ensembl ID		ENSG00000170296	ENSG00000100347
Uniprot IDs		O95166 Q6IAW1	Q9Y512
PDB IDs		1GNU 1KLV 1KM7 1KOT 3D32 3DOW 3WIM 4XC2 5DPS 6HB9 6HOG 6HOH 6HOJ 6HOK 6HYL 6HYM 6HYN 6HYO 6YOP 7AA8 7BRQ 7BRT 7BRU 7BV4 7EA7 7LSW 7LT6 7VEC 7VED 7YO9 7ZKR 7ZL7 8AFI 8S1M 8T2M 8T2N 8T31 8T32 8T33 8W6A	6YOO 6YOP
Enriched GO Terms of Interacting Partners?		Autophagosome Autophagosome Assembly Autophagosome Organization Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Autophagy Autophagy Of Mitochondrion Positive Regulation Of Autophagy Regulation Of Autophagy Microautophagy Macroautophagy Positive Regulation Of Catabolic Process Intracellular Protein Localization Mitophagy Organelle Organization Cellular Component Assembly Cytoplasm Organelle Assembly Protein Modification Process Cytosol Positive Regulation Of Metabolic Process Catabolic Process Cytoplasmic Vesicle Atg1/ULK1 Kinase Complex M Band Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Protein Phosphorylation Protein-phosphatidylethanolamide Deconjugating Activity Establishment Of Protein Localization Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Transport Regulation Of Cell Communication Protein Delipidation Phosphorylation Protein Serine/threonine Kinase Activity Protein Kinase Activity Protein Metabolic Process Regulation Of Signaling Regulation Of Intracellular Signal Transduction Phagophore Assembly Site Membrane Protein Localization To Organelle Defense Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Junction Organization Response To Starvation	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagosome Membrane Autophagosome Maturation Mitochondrial Crista Junction MICOS Complex Autophagy Of Mitochondrion Ceramide Binding Autophagosome SAM Complex MIB Complex Ubiquitin Protein Ligase Binding Autophagosome Assembly Cristae Formation Autophagosome Organization Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Cellular Response To Starvation Inner Mitochondrial Membrane Organization Response To Starvation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organelle Membrane Cellular Response To Nutrient Levels Endomembrane System Autophagy Microtubule Cellular Response To Stress Non-sequence-specific DNA Binding, Bending Mitochondrion Organelle Organization Negative Regulation Of Calcium Import Into The Mitochondrion Positive Regulation Of Protein K48-linked Ubiquitination Mitochondrial Membrane Organization Extrinsic Apoptotic Signaling Pathway Axoneme Response To Nutrient Levels Somite Specification Voltage-gated Monoatomic Anion Channel Activity Supercoiled DNA Binding Porin Activity Regulation Of Calcium Import Into The Mitochondrion Regulation Of Protein K48-linked Ubiquitination Response To Stress Mitochondrial Permeability Transition Pore Complex DNA Geometric Change Mitochondrial Membrane Neuron-neuron Synaptic Transmission
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