GABARAP and ULK2

Number of citations of the paper that reports this interaction (PubMedID 23043107)
55

Data Source:
BioGRID (unspecified method)

		GABARAP	ULK2
Description		GABA type A receptor-associated protein	unc-51 like autophagy activating kinase 2
Image
GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Cytoplasm Lysosome Autophagosome Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Endomembrane System Actin Cytoskeleton Membrane Cytoplasmic Vesicle Sperm Midpiece GABA-ergic Synapse	Phagophore Assembly Site Cytoplasm Autophagosome Cytosol Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Phagophore Assembly Site Membrane
	Molecular Function	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Autophagosome Assembly Microtubule Cytoskeleton Organization Mitophagy Protein Targeting Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Chemical Synaptic Transmission Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Rac Protein Signal Transduction Autophagosome Maturation Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein K48-linked Ubiquitination	Autophagosome Assembly Mitophagy Autophagy Signal Transduction Nervous System Development Axonogenesis Axon Guidance Intracellular Protein Localization Regulation Of Autophagy Piecemeal Microautophagy Of The Nucleus Response To Starvation Protein Autophosphorylation Collateral Sprouting Negative Regulation Of Collateral Sprouting Axon Extension Reticulophagy Somatic Sensory System Development
Pathways		Macroautophagy TBC/RABGAPs
Drugs			Fostamatinib
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		75 interacting genes: AMBRA1 ANK2 ANK3 APPL1 ATG101 ATG13 ATG3 ATG4B ATG4C ATG4D ATG7 ATXN3 AZI2 BICC1 BIRC6 CARS2 CCT2 CDC37 CUL3 DMPK DVL2 FLCN G3BP1 GABRG1 GABRG2 GABRG3 GJA1 GPHN HDAC5 KBTBD7 KDR LMNB1 MAP4K2 MAPK15 MEFV MIB1 MLH1 MPC1 MTX1 MYBPC1 MYBPC2 NBR1 NCOR1 NEDD4 NEK9 NSF NUFIP2 OPTN PCM1 PGS1 PKP4 PRKCZ RB1CC1 RESF1 SAMM50 SEC62 SNX18 SRPK1 SRPK2 STK3 TAX1BP1 TBC1D25 TFRC TLE5 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 TSR2 TTN TUBB3 ULK1 ULK2 VPS28	15 interacting genes: ATG14 DIXDC1 DUXAP9 EEF1B2 GABARAP GABARAPL2 LNX1 LUC7L2 NASP POLA2 SETDB1 SQSTM1 SYNGAP1 TNPO1 ZNF32
Entrez ID		11337	9706
HPRD ID		05496	10556
Ensembl ID		ENSG00000170296	ENSG00000083290
Uniprot IDs		O95166 Q6IAW1	Q8IYT8
PDB IDs		1GNU 1KLV 1KM7 1KOT 3D32 3DOW 3WIM 4XC2 5DPS 6HB9 6HOG 6HOH 6HOJ 6HOK 6HYL 6HYM 6HYN 6HYO 6YOP 7AA8 7BRQ 7BRT 7BRU 7BV4 7EA7 7LSW 7LT6 7VEC 7VED 7YO9 7ZKR 7ZL7 8AFI 8S1M 8T2M 8T2N 8T31 8T32 8T33 8W6A	6QAT 6QAU 6QAV 6YID
Enriched GO Terms of Interacting Partners?		Autophagosome Autophagosome Assembly Autophagosome Organization Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Autophagy Autophagy Of Mitochondrion Positive Regulation Of Autophagy Regulation Of Autophagy Microautophagy Macroautophagy Positive Regulation Of Catabolic Process Intracellular Protein Localization Mitophagy Organelle Organization Cellular Component Assembly Cytoplasm Organelle Assembly Protein Modification Process Cytosol Positive Regulation Of Metabolic Process Catabolic Process Cytoplasmic Vesicle Atg1/ULK1 Kinase Complex M Band Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Protein Phosphorylation Protein-phosphatidylethanolamide Deconjugating Activity Establishment Of Protein Localization Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Transport Regulation Of Cell Communication Protein Delipidation Phosphorylation Protein Serine/threonine Kinase Activity Protein Kinase Activity Protein Metabolic Process Regulation Of Signaling Regulation Of Intracellular Signal Transduction Phagophore Assembly Site Membrane Protein Localization To Organelle Defense Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Junction Organization Response To Starvation	Mitophagy Autophagosome Autophagy Of Mitochondrion Response To Mitochondrial Depolarisation Macroautophagy Autophagosome Maturation Autophagosome Membrane Protein Transport Cellular Response To Nitrogen Starvation Intracellular Protein Localization Establishment Of Protein Localization Phosphatidylethanolamine Binding Autophagosome Assembly Regulation Of Protein Complex Stability GABA Receptor Binding Autophagosome Organization Autophagy Protein Import Into Nucleus Import Into Nucleus Protein Localization To Organelle Establishment Of Protein Localization To Organelle Protein-containing Complex Disassembly Phagophore Assembly Site Vacuole Organization Protein Localization To Nucleus Cellular Response To Starvation Beta-tubulin Binding Regulation Of Ras Protein Signal Transduction Protein Targeting Sperm Midpiece Extrinsic Component Of Phagophore Assembly Site Membrane Protein Targeting To Vacuole Response To Starvation Intracellular Protein Transport Nuclear Transport Nucleocytoplasmic Transport Synapse Organization Establishment Of Protein Localization To Vacuole Cellular Response To Nutrient Levels Brown Fat Cell Proliferation Amphisome Extrinsic Component Of Omegasome Membrane Regulation Of Small GTPase Mediated Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of Protein K48-linked Ubiquitination Protein Localization To Vacuole Eukaryotic Translation Elongation Factor 1 Complex Organelle Assembly Histone H3K9 Trimethyltransferase Activity
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