SIN3B and RNF220

Number of citations of the paper that reports this interaction (PubMedID 20170641)
0

Data Source:
BioGRID (enzymatic study)

		SIN3B	RNF220
Description		SIN3 transcription regulator family member B	ring finger protein 220
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin X Chromosome Y Chromosome XY Body Nucleus Nucleoplasm Cytoplasm Autosome Sin3-type Complex	Nucleus Nuclear Lamina Nucleoplasm Cytoplasm Protein-containing Complex Postsynapse Glutamatergic Synapse
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Cell Migration Negative Regulation Of DNA-templated Transcription	Noradrenergic Neuron Development Protein Monoubiquitination Protein Ubiquitination Dorsal/ventral Neural Tube Patterning Positive Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Transcription Regulatory Region DNA Binding
Pathways		NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Chronic obstructive pulmonary disease ( 30804561) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Interleukin-6 levels ( 22205395) Resting heart rate ( 27798624 29769521)
Interacting Genes		20 interacting genes: AURKA COPS2 H3-4 HDAC1 HDAC9 IKZF1 IKZF4 MAD1L1 MXD1 MXI1 NR1D2 REST RNF220 SETDB1 SMARCA2 SMARCA4 SMARCB1 SMARCE1 TP53 ZBTB16	9 interacting genes: DYRK1A GOPC PELI2 PTGER4 SIN3B UBE2D2 UBE2D3 UBE2L3 USP7
Entrez ID		23309	55182
HPRD ID		09691	13336
Ensembl ID		ENSG00000127511	ENSG00000187147
Uniprot IDs		B7Z392 M0QYC5 O75182	Q5VTB9
PDB IDs		8BPA 8BPB 8BPC 8C60
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Negative Regulation Of RNA Metabolic Process Chromatin Remodeling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Stem Cell Population Maintenance BBAF Complex DNA Binding Negative Regulation Of Macromolecule Metabolic Process NpBAF Complex NBAF Complex Negative Regulation Of Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Protein-containing Complex Nucleus Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Development Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Epigenetic Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Host-mediated Perturbation Of Viral Transcription Regulation Of Nucleotide-excision Repair SWI/SNF Complex Regulation Of Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Developmental Process Regulation Of RNA Metabolic Process Regulation Of G0 To G1 Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Gene Expression Nucleosomal DNA Binding Regulation Of Sister Chromatid Segregation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Myoblast Differentiation Positive Regulation Of T Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Chromosome Organization Positive Regulation Of Cell Differentiation Regulation Of Chromosome Segregation Brahma Complex Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Development RSC-type Complex	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Modification Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein K11-linked Ubiquitination Ubiquitin-protein Transferase Activity Regulation Of Protein Targeting To Mitochondrion Histone H3T45 Kinase Activity Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Anion Channel Activity Protein Autoubiquitination Ubiquitin Protein Ligase Activity Regulation Of Protein Localization Transferase Activity Negative Regulation Of Eosinophil Migration Y Chromosome Autosome Protein Metabolic Process Negative Regulation Of Integrin Activation Protein K48-linked Ubiquitination Symbiont-mediated Disruption Of Host Cell PML Body DNA Repair Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein-containing Complex Assembly Prostaglandin Receptor Activity Proteolysis Regulation Of Establishment Of Protein Localization X Chromosome Negative Regulation Of Heterochromatin Formation Prostaglandin E Receptor Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Toll Signaling Pathway Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Retrograde Transport, Endosome To Golgi ATP Binding Negative Regulation Of Cellular Extravasation Proteolysis Involved In Protein Catabolic Process Regulation Of Heterochromatin Formation Ubiquitin-protein Transferase Activator Activity Monoubiquitinated Protein Deubiquitination
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