SIN3B and SMARCB1

Number of citations of the paper that reports this interaction (PMID 14559996)
80

Data Source:
BioGRID (pull down)

		SIN3B	SMARCB1
Gene Name		SIN3 transcription regulator family member B	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	X Chromosome Y Chromosome XY Body Nucleus Nucleoplasm Cytoplasm Sin3 Complex Autosome	Nuclear Chromatin XY Body Nucleus Nucleoplasm Nucleolus SWI/SNF Complex Protein Complex NpBAF Complex NBAF Complex
	Molecular Function	RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Histone Deacetylase Activity Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding P53 Binding Transcription Coactivator Activity Protein Binding Tat Protein Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Skeletal Muscle Tissue Development Histone Deacetylation Cellular Lipid Metabolic Process Small Molecule Metabolic Process Cardiac Muscle Tissue Development	Blastocyst Hatching DNA Repair Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Negative Regulation Of Cell Proliferation DNA Integration Cell Differentiation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate ATP-dependent Chromatin Remodeling Positive Regulation By Host Of Viral Transcription Mitotic Cell Cycle Phase Transition Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways		NoRC negatively regulates rRNA expression Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS			IgG glycosylation ( 23382691)
Protein-Protein Interactions		19 interactors: COPS2 HDAC1 HDAC9 HIST3H3 IKZF1 IKZF4 MAD1L1 MXD1 MXI1 NR1D2 REST RNF220 SETDB1 SMARCA2 SMARCA4 SMARCB1 SMARCE1 TP53 ZBTB16	40 interactors: AKT1 APP BCL2L11 CALR CDX2 CEBPB DPF2 DPF3 GADD45G GATA1 KLF1 KMT2B KMT2C MAP1LC3B MAPK8IP2 MCPH1 MECP2 MYC NONO NR0B2 NR3C1 PDPK1 PPP1CC PPP1R15A PRMT5 RAN RB1 RELB RPS6KA5 SIN3B SMARCA4 SRC TACC2 TAF1D TP53 UBQLN4 XPO1 YEATS4 ZAK ZDHHC17
Entrez ID		23309	6598
HPRD ID		09691	03364
Ensembl ID		ENSG00000127511	ENSG00000099956
Uniprot IDs		O75182	G5E975 Q12824 Q9H836
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Chromatin Organization Chromosome Organization RNA Metabolic Process Chromatin Modification Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Interaction With Symbiont Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process ATP-dependent Chromatin Remodeling Chromatin Remodeling Nucleosome Disassembly Regulation Of Metabolic Process Regulation Of Viral Transcription Organelle Organization Aortic Smooth Muscle Cell Differentiation Histone H4 Deacetylation Histone H3-K9 Modification Positive Regulation Of NK T Cell Differentiation Chromatin Assembly Or Disassembly Multicellular Organismal Development Hemopoiesis Regulation Of Viral Process Positive Regulation Of Cellular Metabolic Process	Regulation Of Metabolic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Chromatin Organization Positive Regulation Of Metabolic Process Organelle Organization Transcription, DNA-templated Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process Chromatin Modification Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Chromosome Organization Regulation Of Cellular Process RNA Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation System Development Regulation Of Signaling Developmental Process Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Negative Regulation Of Signal Transduction Regulation Of Phosphorylation Anatomical Structure Development Regulation Of Organelle Organization Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Phosphorus Metabolic Process
Tagcloud ?		ablated bcl6 conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3a tafii32 tafii70 tafs terminalrepression tfiib zip	abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Difference) ?		ablated bcl6 conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3a tafii32 tafii70 tafs terminalrepression tfiib zip	abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Intersection) ?