SIN3B and COPS2

Number of citations of the paper that reports this interaction (PubMedID 15173382)
46

Data Source:
BioGRID (pull down)

		SIN3B	COPS2
Description		SIN3 transcription regulator family member B	COP9 signalosome subunit 2
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GO Annotations	Cellular Component	Chromatin X Chromosome Y Chromosome XY Body Nucleus Nucleoplasm Cytoplasm Autosome Sin3-type Complex	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Protein-containing Complex
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Cell Migration Negative Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Protein Deneddylation Inner Cell Mass Cell Proliferation Trophectodermal Cell Proliferation Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Neuron Differentiation Skeletal Muscle Cell Differentiation Protein Neddylation Negative Regulation Of DNA-templated Transcription Regulation Of Protein Neddylation
Pathways		NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS			Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		20 interacting genes: AURKA COPS2 H3-4 HDAC1 HDAC9 IKZF1 IKZF4 MAD1L1 MXD1 MXI1 NR1D2 REST RNF220 SETDB1 SMARCA2 SMARCA4 SMARCB1 SMARCE1 TP53 ZBTB16	39 interacting genes: COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CUL4A CUL5 EP300 GFER GPS1 H3C1 H4C1 ING1 ING2 IP6K1 IRF8 MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 OGT PRKD1 PSMD11 RARA RND1 RXRA SENP8 SIN3A SIN3B THRA THRB TP53 UBC VDR ZNF446
Entrez ID		23309	9318
HPRD ID		09691	05146
Ensembl ID		ENSG00000127511	ENSG00000166200
Uniprot IDs		B7Z392 M0QYC5 O75182	P61201 Q59EL2
PDB IDs		8BPA 8BPB 8BPC 8C60	4D10 4D18 4WSN 6A73 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Negative Regulation Of RNA Metabolic Process Chromatin Remodeling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Stem Cell Population Maintenance BBAF Complex DNA Binding Negative Regulation Of Macromolecule Metabolic Process NpBAF Complex NBAF Complex Negative Regulation Of Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Protein-containing Complex Nucleus Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Development Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Epigenetic Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Host-mediated Perturbation Of Viral Transcription Regulation Of Nucleotide-excision Repair SWI/SNF Complex Regulation Of Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Developmental Process Regulation Of RNA Metabolic Process Regulation Of G0 To G1 Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Gene Expression Nucleosomal DNA Binding Regulation Of Sister Chromatid Segregation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Myoblast Differentiation Positive Regulation Of T Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Chromosome Organization Positive Regulation Of Cell Differentiation Regulation Of Chromosome Segregation Brahma Complex Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Development RSC-type Complex	Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Nucleoplasm Sin3-type Complex Negative Regulation Of Transcription By RNA Polymerase II Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Removal Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Nuclear Receptor Activity MRNA Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification Process Chromatin Regulation Of Post-translational Protein Modification MRNA Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Rhythmic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Histone Deacetylase Regulator Activity Positive Regulation Of RNA Metabolic Process Post-translational Protein Modification Regulation Of Thyroid Hormone Receptor Signaling Pathway DeNEDDylase Activity Negative Regulation Of Stem Cell Population Maintenance Retinoic Acid-responsive Element Binding Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Protein Metabolic Process Regulation Of Protein Modification Process Cytosol
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