CPSF7 and GCC1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CPSF7	GCC1
Gene Name		cleavage and polyadenylation specific factor 7, 59kDa	GRIP and coiled-coil domain containing 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm MRNA Cleavage Factor Complex Membrane	Golgi Membrane Cytoplasm Golgi Apparatus Plasma Membrane
	Molecular Function	Nucleotide Binding Protein Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription RNA Splicing Gene Expression MRNA 3'-end Processing Protein Tetramerization	Protein Targeting To Golgi
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Processing of Capped Intronless Pre-mRNA mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs mRNA 3'-end processing
Drugs
Diseases
GWAS			Type 2 diabetes ( 22158537)
Protein-Protein Interactions		22 interactors: AES APBB1 ARMC7 ATXN1 CLK2 CSNK2A1 DVL2 EPM2AIP1 EWSR1 GCC1 ITCH NCK2 NUDT21 PRMT2 RUNX1T1 SEC23B SMAD3 SNRNP25 SORBS3 U2AF2 WBP4 WWOX	36 interactors: ABI2 AMOTL2 APP ARL1 ATF4 ATN1 BIRC2 BRCA1 C1orf94 CCDC85B CEP57 CEP70 COIL CPSF7 DNAJA3 FBF1 GLI1 GOLGA2 GTF2I IKBKG ITSN1 KIAA0753 KIAA1217 LZTS2 MCRS1 NAB2 NAV1 NECAB2 NINL OIP5 PAK7 SMARCD1 TFIP11 TRIM29 USHBP1 ZNF276
Entrez ID		79869	79571
HPRD ID		16906	07599
Ensembl ID		ENSG00000149532	ENSG00000179562
Uniprot IDs		B4DGF8 Q8N684	A4D0Z4 Q96CN9
PDB IDs		3N9U
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Metabolic Process Gene Expression RNA Processing Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Wnt Signaling Pathway Regulation Of Signaling Nucleobase-containing Compound Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Growth Positive Regulation Of Cell Death Regulation Of Apoptotic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Growth RNA Splicing Regulation Of Cell Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Phosphorylation Negative Regulation Of Signaling Cellular Macromolecule Biosynthetic Process MRNA Processing Macromolecule Biosynthetic Process Positive Regulation Of Signal Transduction Negative Regulation Of Cell Cycle Termination Of RNA Polymerase II Transcription	Apoptotic Process Programmed Cell Death Cell Death Death Organelle Organization Transcription, DNA-templated RNA Metabolic Process Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Intracellular Signal Transduction Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Anatomical Structure Development Developmental Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Toxin Metabolic Process Negative Regulation Of Cell Death Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase III Promoter Nitrogen Compound Metabolic Process G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Cell Communication Positive Regulation Vascular Endothelial Growth Factor Production Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death System Development Multicellular Organismal Development Cellular Process NIK/NF-kappaB Signaling Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Biosynthetic Process Cell Cycle Positive Regulation Of Histone H4-K20 Methylation Spliceosomal Complex Disassembly Positive Regulation Of Histone H4-K16 Acetylation Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Positive Regulation Of Protein K48-linked Ubiquitination
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