CPSF7 and TUT4

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		CPSF7	TUT4
Description		cleavage and polyadenylation specific factor 7	terminal uridylyl transferase 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA Cleavage Factor Complex Membrane	Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity MiRNA Binding Metal Ion Binding RNA Uridylyltransferase Activity
	Biological Process	MRNA Processing MRNA 3'-end Processing Protein Tetramerization Protein Heterotetramerization MRNA Alternative Polyadenylation Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway	Oocyte Maturation MiRNA Metabolic Process MiRNA Catabolic Process Stem Cell Population Maintenance Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing RNA 3'-end Processing Histone MRNA Catabolic Process Transposable Element Silencing By MRNA Destabilization Polyuridylation-dependent MRNA Catabolic Process
Pathways		mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs RHOBTB1 GTPase cycle	Deadenylation of mRNA Zygotic genome activation (ZGA) Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases
GWAS
Interacting Genes		106 interacting genes: ALG13 APBB1 ARMC7 ATXN1 BAG4 BCAS2 CATSPER1 CD2BP2 CEBPA CEP55 CFAP206 CLK2 CSNK2A1 CTBP1 CTTN DMRTB1 DRC4 DVL2 EIF4ENIF1 EPM2AIP1 ESS2 EWSR1 EXOSC1 EXOSC5 EXOSC8 GCC1 GRB2 GTSE1 GUCD1 HINT1 HNRNPF ITCH KHDRBS3 KRT31 LENG1 LENG8 LNX1 LSM5 MAGOH MAILR MIR1-1 MIR1-2 MIR10B MIR128-2 MIR141 MIR155 MIR16-1 MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR25 MIR29C MIR34B MIR7-1 MIR9-2 MIR93 MIRLET7B MREG NCK2 NIP7 NUDT21 NXF1 OGT PATZ1 PID1 PQBP1 PRKAA2 PRMT2 PRPF6 QKI RBFOX2 RBM10 RBM7 RBPMS RUNX1T1 SEC23B SF1 SF3B4 SFPQ SLAIN1 SMAD3 SNRNP25 SNRPC SNRPF SNW1 SNX18 SORBS3 SPG21 SRPK2 SRSF1 SRSF4 SUMO2 SUPT5H TFIP11 TLE5 TNS2 TUT4 TXNL4A U2AF2 UNKL WBP4 WWOX YTHDF1 YTHDF3	13 interacting genes: CPSF7 FXR2 MIR143 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7C MIRLET7D MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I YBX2
Entrez ID		79869	23318
HPRD ID		16906	15700
Ensembl ID		ENSG00000149532	ENSG00000134744
Uniprot IDs		B4DGF8 Q8N684	Q5TAX3
PDB IDs		3N9U	6IW6 8OST
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex MRNA Metabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Regulatory NcRNA-mediated Gene Silencing RNA Processing Negative Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Spliceosomal Complex Negative Regulation Of Gene Expression RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process RNA Binding Regulation Of Gene Expression Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding Regulation Of Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nuclear Speck Regulation Of MRNA Processing Positive Regulation Of MRNA Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of MRNA Catabolic Process Regulation Of MRNA Stability Nucleic Acid Binding Nucleoplasm MRNA Binding Regulation Of RNA Stability MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translation Regulation Of Primary Metabolic Process Catalytic Step 2 Spliceosome Regulation Of RNA Metabolic Process Regulation Of Translation Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Destabilization Positive Regulation Of Catabolic Process Regulation Of Cardiac Muscle Hypertrophy RNA Destabilization	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Gene Expression Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MRNA Destabilization RNA Destabilization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of MRNA Metabolic Process Extracellular Space Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-10 Production Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Translation Regulation Of Endothelial Cell Migration Calcidiol 1-monooxygenase Activity Secalciferol 1-monooxygenase Activity Cellular Response To Amyloid-beta Regulation Of Multicellular Organismal Process Positive Regulation Of Catabolic Process Regulation Of Cell Migration Involved In Sprouting Angiogenesis Response To Amyloid-beta
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